 | | Vol. 13.26 – 13 November, 2024 |
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| | Investigators combined multicolor lineage tracing with chemical mutagenesis in mice to show that a large proportion of intestinal tumors have a multiancestral origin. Polyclonal tumors retained a structure comprising subclones with distinct Apc mutations and transcriptional states. |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| To study the spatial interactions among cancer and non-cancer cells, researchers examined a cohort of 131 tumor sections from 78 cases across six cancer types by Visium spatial transcriptomics.
[Nature] |
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| Investigators enabled highly efficient capture and in situ phenotypic analysis of circulating tumor cells through enhanced and tunable on-chip immunoaffinity binding.
[ACS Nano] |
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| The authors demonstrated that hiPSC-neural stem/progenitor cells adopted a radial glia-associated signature, sharing key epigenetic and transcriptional characteristics with human fetal neural stem cells while exhibiting divergent profiles from glioblastoma stem cells.
[Nature Communications] |
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| Scientists reported a self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer and disulfide-linked all-trans retinoic acid for diagnosis and targeted treatment of CSCs enriched tumors.
[Nature Communications] |
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| Researchers revealed that aberrant pyruvate dehydrogenase kinase 1 (PDK1) expression was closely related to aerobic glycolysis in squamous intraepithelial lesions and poor survival in patients with cervical cancer.
[Advanced Science] |
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| Investigators reported the development of an lysine-specific demethylase (LSD) inhibitor, S2172, which efficiently penetrated the blood-brain barrier. S2172 effectively suppresses LSD1 enzymatic activity, resulting in the depletion of cell growth both in vitro and in vitro models of glioma stem cells.
[Cancer Gene Therapy] |
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| The authors employed a systemic theoretical perspective to integrate experimental knowledge into a core endogenous network model for glioma. The model identifies two stable states corresponding to astrocytic-like and oligodendrocytic-like tumor cells.
[Scientific Reports] |
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| Scientists evaluated 830 flavonoids from the PubChem database against five ALDH isoforms using computational methods to identify potent inhibitors against cancer stem cell protection and maintenance.
[SAR and QSAR In Environmental Research] |
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| The eradication of H. pylori reduces gastric cancer risk, but post-eradication surveillance is essential. Understanding the fundamental mechanisms of gastric carcinogenesis, including the roles of oxidative stress and cancer stem cells, is key to advancing treatment.
[Free Radical Research] |
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| Rush University System for Health announced that it has acquired Quantum Surgical’s Epione® platform. Rush University Medical Center is among a select group of hospitals nationwide — and the first in the Midwest — to adopt this innovative technology.
[Quantum Surgical] |
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| December 11 – 13, 2024
Singapore, Singapore |
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| | University of Lund – Lund, Sweden |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Cornell University – Ithaca, New York, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States of America |
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| | Merk and Co – Shanghai, China |
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