 | | Vol. 13.24 – 16 October, 2024 |
| |
|
|
| To achieve the prediction of tumor diagnosis and progression in colorectal cancer, a new, automated, and portable lateral displacement patterned pump-free microfluidic chip with the CoPt3 nanozyme was established for circulating CSC capture and detection in peripheral blood and feces samples ex vivo.
[ACS Sensors] |
|  |
|
|
| PUBLICATIONSListed by the impact factor of the journal |
|
|
|
| EXO1 downregulation impact on cancer stem-like cell expansion was assessed via flow cytometry. Co-localization of EXO1, Polη and Polι was validated through co-immunoprecipitation and confocal-imaging.
[British Journal of Cancer] |
|
|
|
| The authors performed single-cell mass cytometry analysis of 179,483 single cells to characterize potential immunotherapy-related CSCs-like populations in the tumor microenvironment of 38 muscle invasive bladder cancer tissues.
[Journal of Translational Medicine] |
|
|
|
| Investigators performed unsupervised hierarchical clustering of the gene expression profiles of 117 pituitary adenomas samples to identify three distinct molecular subtypes. Subsequently, we analyzed the compiled transcriptomic profiles of each individual subtype for pathway enrichment.
[Journal of Translational Medicine] |
|
|
|
| The authors analyzed single-cell RNA sequencing data from bone marrow samples of 8 relapsed/refractory acute myeloid leukemia patients and four healthy controls using bioinformatics and machine learning algorithms.
[Stem Cell Research & Therapy] |
|
|
|
| Researchers showed that miR-2117 was downregulated in liver CSCs and predicted the poor prognosis of hepatocellular carcinoma patients.
[Molecular Carcinogenesis] |
|
|
|
| Quantitative real time-PCR and western blot analysis were performed to detect microRNAs and Forkhead box Q1 protein expression, respectively. The breast CSCs were characterized by aldehyde dehydrogenase 1 activity and flow cytometric analysis of CD49f high/CD133high fraction.
[Pharmaceutical Research] |
|
|
|
| Scientists reported the synthesis, characterisation, and anti-breast CSC properties of two copper(II)-terpyridine complexes with bidentate salicylaldehyde moieties.
[ChemBioChem] |
|
|
|
| Elevated tumor NOS2/COX2 limited CD8+ T cell infiltration at five-year survival. Distinct CD8+/-NOS2+/-COX2+/- phenotypes defining metastatic and cancer stem cell niches, and immune desert regions were identified.
[Cancer Research Communications] |
|  |
|
|
|
| The general landscape of splicing aberrations in cancer is not well defined, due to limitations of short-read RNA sequencing not adept at resolving complete mRNA isoforms, as well as the shallow read depth inherent in long-read RNA-sequencing, especially at single-cell level.
[Nature Reviews Cancer] |
|
|
|
| Investigators present a detailed examination of the epigenetic hallmarks affected in human cancer, elucidating the pathways and genes involved, and dissecting the disrupted landscapes for DNA methylation, histone modifications, and chromatin architecture that define the disease.
[Cancer Discovery] |
|
|
|
| Recent ongoing studies examine autophagy/mitophagy as a powerful survival strategy in response to environmental stress including nutrient deprivation, hypoxia and environmental stress in tumormicroenvironment.
[Expert Reviews In Molecular Medicine] |
|
|
|
|
| Emerging protein-design competitions aim to sift out the functional from the fantastical. But researchers hope that the real prize will be a revolution for the field.
[Nature News] |
|
|
|
| Immuneering Corporation announced that the US FDA has granted orphan drug designation to IMM-1-104 in the treatment of pancreatic cancer. IMM-1-104 is currently being evaluated in a Phase IIa clinical trial in patients with advanced solid tumors, including pancreatic cancer.
[Immuneering Corporation] |
|
|
|
|
| November 17-20, 2024
Bellevue, Washington, United States |
|
|
|
|
|
| | University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
|
|
|
| | Fred Hutch Cancer Center – Seattle, Washington, United States |
|
|
|
| | Helmholtz Association of German Research Centres – Julich, Germany |
|
|
|
| | Cancer Research UK – Manchester, England, United Kingdom |
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
