 | | Vol. 13.21 – 18 September, 2024 |
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| An updated analysis of 4037 patients inThe GOZILA study, a nationwide, prospective observational circulating tumor (ct)DNA profiling study, delineated the clinical utility of ctDNA profiling in advanced solid tumors.
[Nature Medicine] |
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| PUBLICATIONSListed by the impact factor of the journal |
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| Scientists revealed that nucleus accumbens associated protein 1 (NAC1), a member of the BTB/POZ gene family, plays a crucial role in triple negative breast cancer by maintaining tumor stemness and influencing myeloid-derived suppressor cells.
[Molecular Cancer] |
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| Investigators performed high-throughput panel-based deep next-generation sequencing and low-pass whole genome sequencing on prospectively collected circulating tumor DNA specimens from 460 patients in the Phase III CHOICE-01 study at different time points.
[Cancer Cell] |
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| The authors found that aldehyde dehydrogenase 1A3 (ALDH1A3) regulates these cancer-promoting processes and the abundance of the two distinct breast CSC populations defined by high ALDH activity and CD24−CD44+ cell surface expression.
[Oncogene] |
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| Scientists demonstrated that the cell surface glycoprotein Mcam maintained the tumorigenic luminal progenitor-like epithelial cell state, leading to Basal-like mammary cancers.
[NPJ Breast Cancer] |
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| Human CRC cells were exposed to 4-HNE, and CSC signaling was analyzed using quantitative real-time PCR, immunofluorescent staining, fluorescence-activated cell sorting, and bioinformatic analysis.
[Antioxidants & Redox Signaling] |
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| Researchers performed univariate regression analyses on the differential genes to identify potential prognostic genes. They created a machine learning framework based on potential prognostic genes, which combines 10 machine learning methods and their 101 combinations to get the optimal prognostic risk model.
[Scientific Reports] |
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| Investigators developed a customized medium to culture primary human intermediate prostate cells, which were transplanted into male immunodeficient NCG mice to examine tumorigenicity in vivo.
[Stem Cell Research] |
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| 75 freshly-resected tumors were analyzed, by flow cytometry. Autofluorescence was categorized as high or low and results were correlated with histological features and clinical variables.
[Cancer Research Communications] |
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| The authors identify limits in the theoretical performance of the clonal evolution model and provide solutions to overcome those limits.
[Nature Reviews Cancer] |
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| Investigators summarize epigenetic modifications of DNA and histones through which CSCs evade immune recognition or elimination, and propose that such alterations constitute promising therapeutic targets to increase the sensitivity of some malignancies to immunotherapy.
[Trends In Cancer] |
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| A gift is set to significantly advance cancer research at Queen’s University. With support from Murray and Cara Sinclair, the university will build research capacity in an area of existing strength, establish advanced facilities and work to improve cancer care and treatments.
[Queen’s University] |
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| Head of Dermatology at Westmead Hospital, Dr. Pablo Fernández-Peñas, and his team of researchers at the Australian Cancer Research Foundation & Australian Centre of Excellence in Melanoma Imaging and Diagnosis, have won the Eureka Prize for Interdisciplinary Scientific Research.
[The Pulse] |
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| October 21-25, 2024
Anaheim, California, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Cambridge Stem Cell Institute – Cambridge, England, United Kingdom |
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| | UT Southwestern – Dallas, Texas, United States |
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| | Fred Hutch Cancer Center – Seattle, Washington, United States |
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| | Tulane University – New Orleans, Louisiana, United States |
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