 | | Vol. 12.01 – 11 January, 2023 |
| |
|
|
| Using lineage tracing, limiting dilution assays, and in vivo live imaging approaches, scientists identified a rare inhibitory receptor programmed cell death 1 (PD-1)-expressing cells that resided at the apex of leukemia hierarchy for initiation and relapse in T cell acute lymphoblastic laukemia.
[Nature Cell Biology] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| METTL16 was aberrantly overexpressed in human acute myeloid leukemia cells, especially in leukemia stem cells and leukemia-initiating cells.
[Cell Stem Cell] |
|
|
|
| To investigate the CSC properties of pancreatic cancer cells, the authors used a pancreatic CSC model, degron (++) cells, which have low proteasome activity. Degron (++) cells displayed radioresistance in comparison with control cells.
[Molecular Therapy] |
|
|
|
| Results using hepatocellular carcinoma patient samples showed a positive correlation between indoleamine 2,3-dioxygenase-1, a kynurenine producing enzyme with effects on tumor immune escape, and Lin28B.
[Molecular Therapy] |
|
|
|
| Scientists demonstrated that RAC1B, the only known alternatively spliced variant of the small GTPase RAC1, was expressed in a subset of breast CSCs (BCSCs) in vivo and its function was required for the maintenance of BCSCs and their chemoresistance to doxorubicin.
[Oncogene] |
|
|
|
| Researchers explored the relationship between mesenchymal circulating tumor cells and Ki67 in hepatocellular carcinoma and their ability to predict prognosis.
[BMC Cancer] |
|
|
|
| High expression of ATP Binding Cassette subfamily C member 3 (ABCC3) was restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlated with tumor grade and stemness markers.
[Scientific Reports] |
|
|
|
| Investigators developed procedures to efficiently activate T cells with tumor-associated antigens to glioblastoma stem cells.
[Scientific Reports] |
|
|
|
| The degree of stromal tumor-infiltrating lymphocytes was evaluated using hematoxylin and eosin-stained slides. Immunohistochemical analysis of B7-H4, CSC-related biomarkers, and epithelial-mesenchymal-transition-related biomarkers was performed using tissue microarray.
[Journal Of Ovarian Research] |
|  |
|
|
|
| CSCs have obvious radio-resistance compared with non-CSCs, and charged particle irradiation or in combination with drugs could overcome this resistance, specifically manifested in inhibiting CSCs’ proliferation, invasion, migration, and causing more DNA double-stranded breaks (DSB) of CSCs.
[Journal Of Cancer Research And Clinical Oncology] |
|
|
|
|
| The initial Phase I clinical trial will assess safety and therapeutic benefit from the administration of Phio’s PH-762 treated “double positive” CD8 tumor infiltrating lymphocyte in patients with melanoma and other advanced solid tumors.
[Phio Pharmaceuticals Corp.] |
|
|
|
| Zai Lab Limited and Novocure announced the LUNAR study met its primary endpoint, demonstrating a statistically significant and clinically meaningful improvement in overall survival over standard therapies alone.
[Zai Lab Limited] |
|
|
|
|
| March 26 – 31, 2023
Ventura, California, United States |
|
|
|
|
|
| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | Stanford Medicine – Stanford, California, United States |
|
|
|
| | Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States |
|
|
|
| | Westlake University – Hangzhou, China |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
