 | | Vol. 10.10 – 17 March, 2021 |
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| Investigators demonstrated how cyclin-dependent kinase 8 (CDK8) played an essential role in maintaining stemness and tumorigenicity in glioma stem cells.
[Oncogene] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors tested HER2-targeted antibody-drug conjugates in two immunocompetent mouse tumor models.
[Cell Chemical Biology] |
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| Scientists observed high Shc3 expression in patients with chemoresistant and recurrent hepatocellular carcinomas. Shc3 overexpression induced a significant increase in MDR1/P-glycoprotein expression, whereas Shc3 knockdown impaired this expression.
[Cell Death & Disease] |
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| Researchers examined p97 expression in the stem-like cancer cells or CSCs, a cell population that purportedly underscores cancer initiation, therapeutic resistance, and recurrence.
[Cell Death & Disease] |
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| The authors showed that the loss of the junctional scaffold protein MAGI1 was associated with bad prognosis in luminal breast cancer, and promoted tumorigenesis.
[Scientific Reports] |
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| Employing hormone-independent mammary cancer models, Gö6976 and all-trans-retinoic acid combined treatment induced a synergistic reduction in proliferative potential that correlated with an increased apoptosis and RARs modulation towards an anti-oncogenic profile.
[Scientific Reports] |
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| The authors investigated B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) expression in brain tumors using microarray datasets in ONCOMINE, which indicated that BMI1 levels were not commonly increased in clinical brain tumors.
[Biochemical and Biophysical Research Communications] |
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| CSC phenotype cells were isolated and the expression of stem cell marker and epithelial-mesenchymal transition associated gene was confirmed by various assays.
[Biochemistry and Cell Biology] |
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Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
[Biochemical Genetics] |
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| Since CSCs mirror the phenotypic behavior of stem cells, scientists describe the roles played by YY1 in embryonic and adult stem cells.
[Stem Cell Reviews and Reports] |
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| The author examines the last two decades of CSC studies in the field. Seminal discoveries, emerging controversies and outstanding questions will be covered with a particular focus on medulloblastoma, the most common malignant primary brain tumor in children.
[FEBS Journal] |
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| AVEO Oncology announced that it has entered into a clinical trial collaboration and supply agreement with Bristol Myers Squibb to evaluate FOTIVDA® in combination with OPDIVO®, Bristol Myers Squibb’s anti-PD-1 therapy, in the pivotal Phase III TiNivo-2 trial in patients with advanced relapsed or refractory renal cell carcinoma following prior immunotherapy exposure.
[AVEO Oncology] |
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| Rubius Therapeutics, Inc. announced initial clinical, pharmacodynamic and tumor trafficking data from its ongoing Phase I/II clinical trial of RTX-240 in patients with advanced solid tumors.
[Rubius Therapeutics, Inc.] |
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| Children’s Cancer Research Fund is proud to award $10.5 million in its latest round of funding. The new grants support 12 research organizations that are working to improve treatment and outcomes for children and adolescents with cancer.
[Children’s Cancer Research Fund] |
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| | University of Arizona Cancer Center – Tucson, Arizona, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | UC San Francisco – San Francisco, California, United States |
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