Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Dysfunction of Cortical GABAergic Projection Neurons As a Major Hallmark in a Model of Neuropsychiatric Syndrome
[Neuron] Single-nucleus transcriptomics revealed the largest gene expression alterations in the somatostatin (Sst) Sst_Chodl subtype, the long-range γ-aminobutyric acid projecting neurons.
Multiscale Proteomic Modeling Reveals Protein Networks Driving Alzheimer’s Disease Pathogenesis
[Cell] Researchers developed multiscale proteomic network models for Alzheimer's disease by integrating large-scale matched proteomic and genetic data from brain regions vulnerable to the disease.
Impaired Macroautophagy in Oligodendrocyte Precursor Cells Suppresses Neuronal Plasticity via a Senescence-Associated Signaling
[Science Advances] Investigators reported a myelination-independent role of oligodendrocyte precursor cells in exaggerating cognitive decline in the aging brain via suppressing neuronal plasticity.
Structural Remodeling of Target-SNARE Protein Complexes by NSF Enables Synaptic Transmission
[Nature Communications] Researchers revealed mechanistic details of AAA+ protein N-ethylmaleimide sensitive factor (NSF) and soluble NSF attachment protein action before fusion.
Tumor Heterogeneity Underlies Clinical Outcome and MEK Inhibitor Response in Somatic NF1-Mutant Glioblastoma
[JCI Insight] Investigators combined bulk and single-cell genomics of human somatic NF1-mutant, isocitrate dehydrogenase wild-type glioblastomas with functional studies in cell lines and mouse intracranial tumor models to identify mechanisms of tumor heterogeneity underlying clinical outcome and MEK inhibitor response.
UDP-Glucose Ceramide Glucosyltransferase Promotes Radioresistance via Membrane Reorganization to Maintain Redox Balance in Glioblastoma
[British Journal of Cancer] The role of UDP-glucose ceramide glucosyltransferase was investigated using radioresistant glioblastoma cell lines and in vivo xenograft models.
Ap1s1 Reduction in the Aging Brain Heightens Neuronal Vulnerability to amyloid-β and Oxidative Stress in Alzheimer’s Pathogenesis
[Alzheimers Research & Therapy] A comprehensive bioinformatic analysis was conducted on brain transcriptomic datasets obtained from both aging individuals and those with Alzheimer’s disease.
Intranasal AdipoRon improves motor function in a rat model of Parkinson’s disease by promoting neurogenesis in the nigrostriatal pathway
[Neuropharmacology] The authors investigated the effect of intranasal AdipoRon on neurogenesis in the nigrostriatal pathway and motor function in a rat Parkinson's disease model.
Axonal Degeneration and Retinal Neurovascular Dysfunction in the TgF344-AD Rat Model of Alzheimer’s Disease
[Journal of Alzheimers Disease] Researchers investigated alterations in the retinal neurovascular unit and associated proteomic changes in the TgF344-Alzheimer's Disease (AD) rat model to determine how these changes relate to brain and known AD pathology.
$10 Million for Neuro-Led Project Seeking New Alzheimer’s Biomarkers
[McGill University] A groundbreaking project led by Dr. Pedro Rosa-Neto at Montreal Neurological Institute-Hospital of McGill University has received a major boost thanks to a $10-million grant from the Weston Family Foundation.
The Alpha7 Nicotinic Acetylcholine Receptor Mediates Network Dysfunction in a Mouse Model of Local Amyloid Pathology
[Molecular Psychiatry] In a mouse model of local amyloid pathology, scientists showed that in the early disease stages, the α7 nicotinic acetylcholine receptor is an important target of amyloid beta in the prefrontal cortex.
On Astrocyte-Neuron Interactions: Broad Insights from the Striatum
[Neuron] Progress concerning how astrocytes affect neurons and neural circuits is summarized by focusing on data and concepts from studies of the striatum, which has emerged as a model nucleus.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
