Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons

February 13, 2025

[Science Translational Medicine] Investigators showed that an MSH3-targeting antisense oligonucleotide effectively engaged with its RNA target in induced pluripotent stem cell (iPSC)–derived striatal neurons obtained from a patient with Huntington’s disease carrying 125 huntingtin CAG repeats.

Loss of ATG7 in Microglia Impairs UPR, Triggers Ferroptosis, and Weakens Amyloid Pathology Control

February 13, 2025

[Journal of Experimental Medicine] Researchers found that microglia-specific deletion of autophagy-related (Atg) 7 in an Alzheimer's disease mouse model impaired microglia coverage of Aβ plaques, increasing plaque diffusion and neurotoxicity.

GPR37L1 Identifies Spinal Cord Astrocytes and Protects Neuropathic Pain after Nerve Injury

February 13, 2025

[Neuron] Through single-nucleus RNA sequencing, the authors identified Gpr37l1 as a selective G-protein-coupled receptor marker for spinal cord astrocytes.

The Dynamic Axon Initial Segment: From Neuronal Polarity to Network Homeostasis

February 13, 2025

[Neuron] Scientists highlight the functions of the axon initial segment, its architecture, and how its organization and remodeling are influenced by developmental plasticity and both acute and chronic adaptations.

IPI Receives Grant from Chan Zuckerberg Initiative to Develop Next-Generation Protein Tools for Neuroscience Research

February 12, 2025

[The Institute for Protein Innovation] The Institute for Protein Innovation (IPI) announced that it received a $500,000 grant from the Chan Zuckerberg Initiative to develop innovative protein-based tools for neuroscience research.

Heat-Shock Chaperone HSPB1 Mitigates Poly-Glycine-Induced Neurodegeneration via Restoration of Autophagic Flux

February 12, 2025

[Autophagy] Scientists explored the role of the small molecular chaperone HSPB1 in counteracting neurodegeneration induced by poly-glycine aggregates.

TRAF3 Loss Protects Glioblastoma Cells from Lipid Peroxidation and Immune Elimination via Dysregulated Lipid Metabolism

February 12, 2025

[Journal of Clinical Investigation] The authors reported that loss of tumor necrosis factor receptor-associated factor 3 (TRAF3) in glioblastoma critically regulated lipid peroxidation and tumorigenesis by controlling the oxidation of polyunsaturated fatty acids.

CD47 Knock-Out Using CRISPR-Cas9 RNA Lipid Nanocarriers Results in Reduced Mesenchymal Glioblastoma Growth In Vivo

February 12, 2025

[Advanced Science] Scientists proposed the use of lipid nanoparticles encapsulating CRISPR RNAs as an in vivo screening tool for immune checkpoints in a syngeneic model of mesenchymal glioblastoma cancer stem cells.

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GNE-317 Reverses MSN-Mediated Proneural-to-Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

February 12, 2025

[Advanced Science] The authors found that moesin acts as a key promotor of chemoradiotherapy resistance in glioma stem cells, enhancing their proliferation and stemness maintenance.

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Overexpression of TGFBR3 Aggravates Cognitive Impairment and Neuroinflammation by Promoting Microglia M1 Polarization in the APP/PS1 Mouse Model of Alzheimer’s Disease

February 11, 2025

[Molecular Neurobiology] Researchers validated the elevated levels of TGFBR3 in postmortem brain tissues from Alzheimer's disease patients using immunohistochemical staining.

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Identification of a Novel Population of Neuromedin S Expressing Neurons in the Ventral Tegmental Area that Promote Morphine-Elicited Behavior

February 11, 2025

[Journal of Neuroscience] The authors used translating ribosome affinity purification and RNA sequencing to identify gene expression changes in mouse ventral tegmental area dopamine neurons following chronic morphine exposure.

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STAT3-Controlled CHI3L1/SPP1 Positive Feedback Loop Demonstrates the Spatial Heterogeneity and Immune Characteristics of Glioblastoma

February 11, 2025

[Developmental Cell] Researchers demonstrated that chitinase-3-like protein 1 (CHI3L1) played a critical role in maintaining mesenchymal status and reprogramming macrophage phenotype using C57BL/6 and NSG mice models derived from PN20 cells.

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Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.