Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Subscribe|Follow Us On

Sertm2 Is a Conserved Micropeptide That Promotes GDNF-Mediated Motor Neuron Subtype Specification

March 20, 2025

[EMBO Reports] Scientists investigated the function of murine micropeptide Sertm2, encoded by the lncRNA A730046J19Rik, during spinal motor neuron development.

Primary Cilia Shape Postnatal Astrocyte Development through Sonic Hedgehog Signaling

March 20, 2025

[Journal of Cell Science] Researchers showed that a sub-population of developing astrocytes in the prefrontal cortex were ciliated. This population corresponded to proliferating astrocytes and largely expressed the ciliary protein ARL13B.

Genetic Sequencing Project Receives More Than $8 Million in Funding

March 19, 2025

[McGill University] A project led by Drs. Ziv Gan-Or and Martine Tétreault has received more than $8 million to sequence the genomes of 8,700 people, to map the role of genetics in neurological disorders.

Dock1 Functions in Schwann Cells to Regulate Development, Maintenance, and Repair

March 19, 2025

[Journal of Cell Biology] The authors demonstrated that Dock1 was necessary for myelin maintenance and remyelination after injury in adult zebrafish.

Disease Modification upon 2 Weeks of Tofacitinib Treatment in a Mouse Model of Chronic Epilepsy

March 19, 2025

[Science Translational Medicine] Investigators confirmed a previously described pattern of rapid and transient induction of the Janus kinase/signal transducer and activator of transcriptioN pathway within days of epileptogenic insult.

Molecularly Distinct Striatonigral Neuron Subtypes Differentially Regulate Locomotion

March 19, 2025

[Nature Communications] Using the genetic markers Kremen1 and Calb1, researchers demonstrated in mouse models that Kremen1+ and Calb1+ striatonigral neurons exerted opposing effects on locomotion.

α-Synuclein Expression in Glioblastoma Restores Tumor Suppressor Function and Rescues Temozolomide Drug Resistance

March 19, 2025

[Cell Death & Disease] Investigators showed that the expression of α-syn was detected in 1p/19q-codeleted and isocitrate dehydrogenase (IDH)-mutant oligodendroglioma and in IDH-wild-type glioblastoma.

Neural Mechanisms Underlying Reduced Nocifensive Sensitivity in Autism-Associated Shank3 Mutant Dogs

March 18, 2025

[Molecular Psychiatry] To investigate the role of SHANK3 in pain processing, scientists conducted behavioral, electrophysiological, and pharmacological tests upon nociceptive stimulation in a Shank3 mutant dog model.

EIF4A3-Induced circ_0029941 Promotes Astrocyte Activation through Enhancing Autophagy Via Mir-224-5p/NFAT5 Axis

March 17, 2025

[Molecular Neurobiology] Transient middle cerebral artery occlusion was constructed to mimic acute ischemic stroke (AIS) mice model, and oxygen–glucose deprivation/reoxygenation-induced astrocytes were used to mimic AIS cell model.

ATG2A Acts As a Tether to Regulate Autophagosome-Lysosome Fusion in Neural Cells

March 14, 2025

[Autophagy] Researchers reported that in neuroblastoma-derived Neuro-2a cells, knocking down Atg2a, but not Atg2b, resulted in significant accumulation of SQSTM1/p62 and MAP1LC3/LC3-II, indicating impaired autophagy.

p-Coumaric Acid Alleviates Neuronal Damage in Ischemic Stroke Mice by Promoting BACH1 Nuclear Export and Degradation

March 14, 2025

[Acta Pharmacologica Sinica] Scientists investigated whether and how p-Coumaric acid regulated BTB and CNC homology 1 (BACH1) in ischemic/reperfusion injury from the perspective of BACH1 subcellular localization and function.

FKBP51 in Glutamatergic Forebrain Neurons Promotes Early Life Stress Inoculation in Female Mice

March 14, 2025

[Nature Communications] The contribution of FKBP51 in glutamatergic forebrain neurons to the long-term consequences of early life stress was investigated in both sexes.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.