Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Hippocampal Output Suppresses Orbitofrontal Cortex Schema Cell Formation

April 14, 2025

[Nature Neuroscience] Researchers tested between a serial model and a parallel model by asking how schema correlated in rat orbitofrontal cortex would be affected by inactivating the output of the hippocampus, after learning and during transfer across problems.

Mettl3 Regulates the Pathogenesis of Alzheimer’s Disease via Fine-Tuning Lingo2

April 9, 2025

[Molecular Psychiatry] Researchers showed that the levels of Mettl3 and m6A modification were increased in specific brain regions of 5xFAD mice and post-mortem Alzheimer’s disease patients, respectively.

microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity

April 9, 2025

[Proceedings of The National Academy of Sciences of The United States of America] miR-218-5p had been identified to coordinate both excitatory and inhibitory synaptic scaling during activity-dependent homeostatic synaptic plasticity.

Oligodendroglial Precursor Cells Modulate Immune Response and Early Demyelination in a Murine Model of Multiple Sclerosis

April 9, 2025

[Science Translational Medicine] The authors induced experimental autoimmune encephalomyelitis in a transgenic mouse to mimic overactivated Wnt signaling in oligodendrocyte precursor cells, a pathological feature in patients with multiple sclerosis.

Psilocybin’S Lasting Action Requires Pyramidal Cell Types and 5-HT2A Receptors

April 9, 2025

[Nature] Researchers used in vivo optical imaging, chemogenetic perturbation, and cell-type-specific electrophysiology to investigate the impact of psilocybin on the two main types of pyramidal cells in the mouse medial frontal cortex.

RIPK3 Coordinates RHIM Domain-Dependent Antiviral Inflammatory Transcription in Neurons

April 9, 2025

[Science Signaling] The authors showed that RIPK3 activation had distinct outcomes in primary cortical neurons when compared with mouse embryonic fibroblasts during Zika virus infection or after sterile activation.

SFRP1 Upregulation Causes Hippocampal Synaptic Dysfunction and Memory Impairment

April 9, 2025

[Cell Reports] The authors generated and analyzed transgenic mice overexpressing astrocytic Secreted Frizzled Related Protein 1 (SFRP1).

ESCRT-I and PTPN23 Mediate Microautophagy of Ubiquitylated Tau Aggregates

April 9, 2025

[Journal of Cell Biology] Scientists identified the UBAP1-containing ESCRT-I complex and PTPN23 as new regulators for degradation of aggregated proteins through an unbiased genome-wide CRISPR knockout screen, using a cell line expressing tau repeat domain aggregates.

Targeting Neurodegenerative Disease-Associated Protein Aggregation with Proximity-Inducing Modalities

April 9, 2025

[Acta Pharmacologica Sinica] The authors summarize the regulatory mechanisms of protein aggregation, highlight the advancements in proximity-inducing modalities for neurodegenerative diseases, and discuss the current challenges and future directions in therapeutic development.

Top American Scientists Just Lost Their Jobs. Canada Is Rolling out the Welcome Mat

April 9, 2025

[CBC] Health Secretary Robert F. Kennedy Jr. is aiming to cut 20,000 jobs at agencies like the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH) and the FDA. Canadian provinces are already trying to attract American health experts suddenly out of a job.

Weill Cornell Medicine Researcher Wins the SPARK NS 2025 Immersive Translational Research Grant

April 9, 2025

[Weill Cornell Medicine] Dr. Timothy Ryan has been named one of eight academic principal investigators to participate in the SPARK NS Translational Research Program, 2025 cohort.

Accure Therapeutics Awarded a Total of $1.6M in Grants from the Michael J. Fox Foundation and Fonds National De Recherche De Luxembourg to Bring...

April 9, 2025

[Accure Therapeutics] Accure Therapeutics announced its receipt of two grants totalling $1.6M for two separate development programs on its drug candidate ACT-02. ACT-02 is a novel asset with disease-modifying potential, inhibiting Prolyl Endopeptidase (PREP), a promising but previously overlooked target in Parkinson’s disease.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.