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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Phase I Study of Safety and Preliminary Efficacy of Intranasal Transplantation of Human Neural Stem Cells (ANGE-S003) in Parkinson’s Disease
[Movement Disorders] Scientists investigated the safety and tolerability of intranasal transplantation of ANGE-S003 human neural stem cells in patients with Parkinson’s disease. Treatment with ANGE-S003 was feasible, generally safe and well tolerated, associated with functional improvement in clinical outcomes.
Astrocytic Proteostasis in the Tale of Aging and Neurodegeneration
[Ageing Research Reviews] The authors argue that the understanding of astrocytic proteostasis role in neuronal physiology and functional decay may arise as a potential new avenue of intervention in neurodegenerative diseases and grant relevant data in the biology of aging.
The Pathogenic APP N-Terminal Val225Ala Mutation Alters Tau Protein Liquid-Liquid Phase Separation and Exacerbates Synaptic Damage
[Molecular Psychiatry] Researchers found that amyloid precursor protein (APP)V225A mutation altered the N-terminal structure of APP, which enhanced its binding affinity to tau protein and significantly increased APP-mediated endocytosis.
Cell Type–Specific Gene Therapy Confers Protection Against Motor Neuron Disease Caused by a TFG Variant
[Proceedings of The National Academy of Sciences of The United States of America] Scientists demonstrated that the reintroduction of wild-type TFG into synapsin 1-positive neurons provided robust protection against motor neuron disease, whereas its expression in GFAP-positive glial cells provided no significant improvement in quantitative measures of gait.
Pharmacogenomic Screening Identifies and Repurposes Leucovorin and Dyclonine as Pro-Oligodendrogenic Compounds in Brain Repair
[Nature Communications] Scientists presented a pharmacogenomic approach that identified compounds with pro-oligodendrogenic activity. Through in vitro neural and oligodendrocyte progenitor cell cultures and mouse models of preterm-birth brain injury and MS, they identified leucovorin and dyclonine as promising candidates.
TARGET-Seq: Linking Single-Cell Transcriptomics of Human Dopaminergic Neurons with Their Target Specificity
[Proceedings of The National Academy of Sciences of The United States of America] Researchers developed an approach termed Tagging projections by AAV-mediated RetroGrade Enrichment of Transcriptomes (TARGET)-seq, that linked the transcriptional profile of the dopaminergic neurons with their innervation of specific target structures in the forebrain.
Trojan Horse Strategy for Wireless Electrical Stimulation-Induced Zn2+ Release to Regulate Neural Stem Cell Differentiation for Spinal Cord Injury Repair
[ACS Nano] The authors developed Zn-PDA@BT nanoparticles acted as Trojan Horse to enter cells through endocytosis for Zn2+-controlled release therapy by the potentials generated by the piezoelectric effect.
Targeting Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential
[Acta Pharmacologica Sinica] Scientists illuminate the molecular mechanisms and regulatory pathways governing chaperone-mediated autophagy (CMA). They discuss the potential roles of CMA in maintaining neuronal proteostasis and modulating neuroinflammation mediated by glial cells.
Redox Regulation, Protein S-Nitrosylation, and Synapse Loss in Alzheimer’s and Related Dementias
[Neuron] Investigators review recent findings that show how normal aging, infection/inflammation, trauma, environmental toxins, and diseases associated with protein aggregation can each trigger excessive nitrosative stress, resulting in aberrant protein S-nitrosylation and hence dysfunctional protein networks.
White Matter Aging and Its Impact on Brain Function
[Neuron] The authors discuss the structural alterations in white matter that occur with aging and examine the cellular and molecular mechanisms driving these aging-related transformations. They highlight how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage.
Decoding Transcriptional Identity in Developing Human Sensory Neurons and Organoid Modeling
[Cell] This atlas revealed the diversity of cell types and highlighted the extrinsic signaling cascades and intrinsic regulatory hierarchies that guide cell fate decisions, including neuronal/glial lineage restriction, sensory neuron differentiation and specification, and the formation of neuron-satellite glial cell units.
Astrocyte Transcriptomic Changes Along the Spatiotemporal Progression of Alzheimer’s Disease
[Nature Neuroscience] Scientists performed single-nucleus RNA sequencing of 628,943 astrocytes from five brain regions representing the stereotypical progression of Alzheimer’s disease (AD) pathology across 32 donors spanning the entire normal aging to severe AD continuum.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
