Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Targeting cIAP2 in a Novel Senolytic Strategy Prevents Glioblastoma Recurrence after Radiotherapy

February 20, 2025

[EMBO Molecular Medicine] The authors reported that ionizing radiation-induced senescence of tumor cells counterintuitively spurred glioblastoma recurrence, driven by the senescence-associated secretory phenotype.

Neuronal FAM171A2 Mediates α-synuclein Fibril Uptake and Drives Parkinson’S Disease

February 20, 2025

[Science] Researchers identified FAM171A2 as a Parkinson's disease risk gene that affected α-syn aggregation. Overexpressing FAM171A2 promoted α-syn fibril endocytosis and exacerbated the spread and neurotoxicity of α-syn pathology.

Drug Repurposing for Alzheimer’s Disease and Other Neurodegenerative Disorders

February 19, 2025

[Nature Communications] The authors define repurposing, describe the advantages and challenges of repurposing, offer strategies for overcoming the obstacles, and describe the key contributions of repurposing to the drug development ecosystem.

SwRI Collaborates with UTSA to Track Neurons with Machine Vision Algorithms

February 19, 2025

[Southwest Research Institute] Southwest Research Institute (SwRI) collaborated with The University of Texas at San Antonio (UTSA) to track individual brain cells undergoing neurogenesis, the process where new neurons grow and connect to neuronal networks.

Transcriptomic Neuron Types Vary Topographically in Function and Morphology

February 18, 2025

[Nature] To uncover the cell-type architecture of the tectum, scientists transcriptionally profiled its neurons, revealing more than 60 cell types that were organized in distinct anatomical layers.

Thalamic Opioids from POMC Satiety Neurons Switch On Sugar Appetite

February 18, 2025

[Science] Investigators discovered that pro-opiomelanocortin (POMC) neurons not only promoted satiety in fed conditions but concomitantly switched on sugar appetite, which drove overconsumption.

Krüppel-Like Factor 9 Alleviates Alzheimer’s Disease via IDE-Mediated Aβ Degradation

February 18, 2025

[Acta Pharmacologica Sinica] Scientists revealed that global Krüppel-like factor 9 (Klf9)-mutant mice exhibited impaired cognitive function. Additionally, they found that Klf9 expression in hippocampal tissue was reduced in APPswe/PS1dE9 mice.

Stepwise Activation of SARM1 for Cell Death and Axon Degeneration Revealed by a Biosynthetic NMN Mimic

February 18, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators reported the identification of a potent proactivator of SARM1, G10, which was converted into a direct activator by the enzyme nicotinamide phosphoribosyltransferase.

Transcriptional Enhancers in Human Neuronal Differentiation Provide Clues to Neuronal Disorders

February 14, 2025

[EMBO Reports] Researchers employed a human mesencephalic neuronal cell differentiation model, LUHMES, with sensitive and high-resolution methods to discover enhancers, perform DNA conformation analysis to link enhancers to their target genes, and finally validate selected interactions.

Phenotypic Rescue via mTOR Inhibition in Neuron-Specific Pten Knockout Mice Reveals AKT and mTORC1-Site Specific Changes

February 14, 2025

[Molecular Psychiatry] Researchers generated a novel neuron-specific Pten knock-out mouse model to test the ability of pharmacologic mTOR inhibition to rescue Pten mutation-associated disease phenotypes in vivo and in vitro.

Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons

February 13, 2025

[Science Translational Medicine] Investigators showed that an MSH3-targeting antisense oligonucleotide effectively engaged with its RNA target in induced pluripotent stem cell (iPSC)–derived striatal neurons obtained from a patient with Huntington’s disease carrying 125 huntingtin CAG repeats.

Loss of ATG7 in Microglia Impairs UPR, Triggers Ferroptosis, and Weakens Amyloid Pathology Control

February 13, 2025

[Journal of Experimental Medicine] Researchers found that microglia-specific deletion of autophagy-related (Atg) 7 in an Alzheimer's disease mouse model impaired microglia coverage of Aβ plaques, increasing plaque diffusion and neurotoxicity.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.