[Cardiovascular Diabetology] Cardiomyocyte-specific NHE1 ablation or pharmacological inhibition worsened cardiac dysfunction and fibrosis in MI with acute hyperglycemia, while NHE1 overexpression conferred protection.

[Aging Cell] The authors aimed to understand how aging impacts mitochondrial 3D structure and its regulators in skeletal muscle. They hypothesized that aging led to remodeling of mitochondrial 3D architecture permissive to dysfunction and was ameliorated by exercise.

[Advanced Science] Investigators defined the role of CCDC80 in the formation and development of aortic dissection (AD). Significant downregulation of CCDC80 in vascular smooth muscle cell in human and mouse AD was identified.

[Kaohsiung Journal of Medical Sciences] Researchers explored the differential expression of lncRNA PVT1 in intracranial aneurysms and its role in the phenotypic switching of vascular smooth muscle cells.

[Biogerontology] The authors explore the most recent discoveries regarding the role of senescent cell accumulation and calcium signalling perturbances in cardiac aging.

[Italfarmaco S.p.A. (BioSpace)] Italfarmaco S.p.A. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending the granting of a conditional marketing authorization for Duvyzat^®, a novel histone deacetylase inhibitor. The authorization is for the treatment of patients with Duchenne muscular dystrophy aged six years and older who are able to walk, when taken together with corticosteroids.

[Signal Transduction and Targeted Therapy] The authors discovered that during myocardial ischemia-reperfusion, double-stranded DNA-cyclic GMP-AMP synthase-stimulator of interferon genes (STING) signal accumulated, accompanied by high rates of myocardial ferroptosis.

[Nature] Investigators showed that the core circadian transcription factor BMAL1 regulated circadian-dependent myocardial injury by forming a transcriptionally active heterodimer with a non-canonical partner, hypoxia-inducible factor 2 alpha (HIF2A), in a diurnal manner.

[Stem Cell Research & Therapy] Serum- and glucose-free media was used to expose hiPSC-derived cardiomyocytes to hypoxia for 6 hours, followed by reoxygenation for 16 hours.

[PeerJ]

[Nature Materials] Scientists introduced a bioconstruct engineered for the staged release of growth factors, tailored to direct different phases of muscle regeneration.

[FASEB Journal] Transcriptomic profiling of the human response to exercise revealed that the nuclear receptor NR4A3 (NOR-1) was among the most responsive genes to acute exercise.