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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Specific Induction of Right Ventricular-Like Cardiomyocytes from Human Pluripotent Stem Cells
Scientists established a methodology to generate right ventricle-like human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) to support the development of disease modeling research using chamber-specific...
Targeting Lysozyme 2 in Endocardium Promotes Rapid Recovery by Modulating Remote Injury Signals
[Cell Stem Cell] Researchers showed that both Lyz2 knockout and pharmacological inhibition of lysosomal degradation confer rapid functional recovery in injured non-regenerative hearts. Thus, targeting a remote injury response in a non-cardiomyocyte cell type rapidly promotes post-myocardial infarction recovery of non-regenerative hearts.
ACAA2 Lactylation and Expression Mediate Mitochondrial Dysfunction in Phenylephrine-Induced Cardiomyocyte Hypertrophy
[Biochemical and Biophysical Research Communications] Scientists investigated ACAA2, a fatty acid β-oxidation enzyme, exploring its lactylation dynamics and metabolic implications in pressure overload-induced cardiomyopathy. Neonatal rat ventricular myocytes were stimulated with phenylephrine to induce cardiomyocyte hypertrophy.
Muscle-Specific Increased Expression of JAG1 Improves the Skeletal Muscle Phenotype in Dystrophin-Deficient Mice
[Proceedings of the National Academy of Sciences of the United States of America] Investigators increased expression of human JAG1 in mouse skeletal muscles lacking dystrophin to explore mechanisms responsible for these benefits.
A Traditional Herbal Decoction Regulates Skeletal Muscle Satellite Cell Osteogenesis and Myogenesis for Repairing Osteosarcopenic Fractures via β-Catenin
[Stem Cell Research & Therapy] Researchers investigated the impact of a traditional herbal decoction, the Invigorate the Spleen and Tonify the Kidney Formula, on skeletal muscle satellite cell regulation, muscle regeneration, and fracture healing.
Targeting Nav1.5 with DKK678 Attenuates NF-κB-Driven Inflammatory Injury in Skeletal Muscle
[International Immunopharmacology] Voltage-gated sodium channels subtype Nav1.5 was investigated as a potential regulator of inflammation, and the therapeutic efficacy of a novel recombinant scorpion peptide, DKK678, was evaluated.
Engineering a Serum Response Factor Superactivator of Smooth Muscle Gene Expression with a Condensate-Forming Domain
[Proceedings of the National Academy of Sciences of the United States of America] Scientists engineered a “superactivator” of smooth muscle genes by replacing serum response factor's (SRF’s) weak TAD with that of MYOCD, thereby enabling SRF to form nuclear condensates and reprogram fibroblasts into smooth muscle cells.
CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis
[Antioxidants & Redox Signaling] Researchers identified circGNAQ as a novel regulator of vascular smooth muscle cell phenotypic switching and apoptosis through targeting serine/arginine-rich splicing factor 1.
Fractalkine Is a Key Player in Skeletal Muscle Metabolism and Pathophysiology
[FEBS Journal] The authors critically assess recent advances in fractalkine research, including its mechanism of action, and explore its potential implications in physiological and pathological scenarios.
Rewiring Cell Identity and Metabolism to Drive Cardiomyocyte Proliferation
[Cell Regeneration] Scientists highlight recent advances in the molecular and metabolic control of cardiomyocyte cell-cycle reentry, focusing on strategies that modulate dedifferentiation, proliferation, and redifferentiation as well as metabolic state transitions.
Dyne Therapeutics Receives Orphan Drug Designation in Japan for DYNE-251 in Duchenne Muscular Dystrophy
[Dyne Therapeutics, Inc.] Dyne Therapeutics, Inc. announced that the Ministry of Health, Labour and Welfare in Japan has granted Orphan Drug designation for DYNE-251 in individuals with Duchenne muscular dystrophy (DMD) who have mutations in the DMD gene that are amenable to exon 51 skipping.
Sex-Based Differences in Mitochondrial Activity and Cellular Calcium Signaling in Isolated Mice Cardiomyocytes Intervened by Doxorubicin
[Biochemical and Biophysical Research Communications] Scientists investigated the impact of low-dose and short-term DOX treatment on mitochondrial activity, reactive oxygen species, and calcium signaling in cardiomyocytes isolated from adult male and female C57BL/6 mice.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
