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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Opposing Role for Myeloid and Smooth Muscle Cell STING in Pulmonary Hypertension
[JCI Insight] Through generation of bone marrow chimeric mice, researchers showed that STING-/- mice receiving wild-type bone marrow are protected against pulmonary hypertension secondary to chronic hypoxia.
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
[Circulation Research] Exercise enhances metabolic health by promoting muscle growth, mitochondrial biogenesis, and improved nutrient storage while preventing age-related muscle dysfunction.
OTUD1 Deficiency Attenuates Myocardial Ischemia/Reperfusion Induced Cardiomyocyte Apoptosis by Regulating RACK1 Phosphorylation
[Acta Pharmacologica Sinica] Scientists investigated the role and molecular mechanism of Ovarian tumor deubiquitinase 1 (OTUD1) in ischemia/reperfusion induced myocardial injury.
Exercise-Induced CLCF1 Attenuates Age-Related Muscle and Bone Decline in Mice
[Nature Communications] The authors identified myokines that have the potential to ameliorate age-related muscle and bone decline.
Identification of a Resistance-Exercise-Specific Signaling Pathway That Drives Skeletal Muscle Growth
[Nature Metabolism] Using a model of unilateral exercise in male participants and deep phosphoproteomic analyses, researchers find that a prolonged activation of a signaling pathway involving MKK3b/6, p38, MK2 and mTORC1 occurs specifically in response to resistance exercise.
High Resolution Melt Electro-Written Scaffolds Promote Alignment of Human Skeletal Muscle Cells
[Biofabrication] Scientists examined how scaffold fiber orientation influences mechanical properties and cellular behaviour by utilising melt electrowriting as a high-resolution 3D printing technique that combines aspects of electrospinning and melt based polymer deposition.
A Combined Experimental and Computational Analysis of mantATP Turnover in Skinned Muscle Fibers
[Proceedings of The National Academy of Sciences of The United States of America] Researchers combined experimental data and in silico modeling to dissect the contributions of different components in the mantATP chasing signal.
Novel Roles of Nrf3-Trim5 Axis in Vascular Smooth Muscle Cell Dysfunctions and Neointimal Hyperplasia
[Cardiovascular Research] Transcriptome dataset and human atherosclerotic samples were used to determine nuclear factor erythroid 2-related factor 3 (Nrf3) expression levels. Global and vascular smooth muscle cell (VSMC)-specific Nrf3 knockout mice were used to assess the role of Nrf3 in VSMC function and injury-induced neointimal hyperplasia.
Phosphatase-Independent Activity of Smooth-Muscle Calcineurin Orchestrates a Gene Expression Program Leading to Hypertension
[PLOS Biology] By employing newly created smooth muscle cell (SMC)-specific and endothelial cell (EC)-specific calcineurin (Cn)-deficient mice, researchers showed that Cn expressed in SMCs, but not ECs, was required for Ang-II-induced abdominal aortic aneurysm.
FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes
[Circulation Research] Type 2 diabetes increased cardiac CD36 S-acylation, CD36 sarcolemmal localization, fatty acid oxidation rates, and triglyceride storage in the diabetic heart.
SENP2-Mediated Desumoylation of NCOA4 Protects against Ferritinophagy-Dependent Ferroptosis in Myocardial Ischemia-Reperfusion Injury
[Autophagy] Researchers found that SENP2 expression decreased following myocardial ischemia reperfusion injury. Deletion of SENP2 increased cardiomyocyte ferroptosis and hindered cardiac function recovery after myocardial ischemia-reperfusion injury.
METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy
[Circulation] Cardiomyocyte-specific N6-adenosine-methyltransferase-like 3 (METTL3) knockout mice and their wild-type littermates were subjected to either chow diet or high-fat diet feeding and injection of streptozotocin to induce diabetic cardiomyopathy.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
