Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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Single-Cell RNA Sequencing in Human Atherosclerotic Plaques Reveals a Novel Smooth Muscle Cell Subtype That Possesses Multi Differentiation Potential and Shapes the Microenvironment

July 21, 2025

[Clinical and Experimental Medicine] To investigate the heterogeneity of smooth muscle cell subsets in lesion, researchers integrated three single-cell RNA sequencing datasets.

Targeting ALDH2 to Promote Skeletal Muscle Health: A Novel Strategy against Mitochondrial Dysfunction

July 21, 2025

[Journal of Physiology] Interventions capable of increasing aldehyde dehydrogenase 2 (ALDH2) levels and/or activity are considered promising therapeutic strategies for mitigating oxidative damage, enhancing mitochondrial function, and preserving muscle integrity under adverse conditions.

£1million to Help Find New Treatments for Muscle Wasting Condition

July 21, 2025

[University College London (UCL)] Muscular Dystrophy UK has funded the new project, TRANSFORM-CMT, led by Professor Mary Reilly MBE, at UCL Queen Square Institute of Neurology.

Cardiomyocyte OTUD1 Drives Diabetic Cardiomyopathy via Directly Deubiquitinating AMPKα2 and Inducing Mitochondrial Dysfunction

July 21, 2025

[Nature Communications] Researchers investigated the role and regulating mechanism of a deubiquitinating enzyme, ovarian tumor domain-containing protein 1 (OTUD1), in diabetic cardiomyopathy.

Human Formin FHOD3-Mediated Actin Elongation Is Required for Sarcomere Integrity in Cardiomyocytes

July 21, 2025

[eLife] Investigators demonstrated that human formin homology domain-containing protein (FHOD) 3L nucleates actin and rapidly but briefly elongates filaments after temporarily pausing elongation.

Microtubules Coordinate Mitochondria Transport with Myofibril Morphogenesis during Muscle Development

July 21, 2025

[Developmental Cell] The authors used in vivo imaging to investigate myofibril and mitochondria network dynamics in developing Drosophila flight muscles.

The Tumor Suppressor pRb and Its Relative p130 Are Required to Maintain Murine Adult Skeletal Muscle Homeostasis

July 21, 2025

[Oncogene] Scientists showed that targeted deletion of murine Rb in proliferating myoblasts during myogenesis, using a Pax7-Cre deleter line, leads to muscle fiber degeneration, short myotubes with elongated, large nuclei, reduced late muscle marker expression, and fetal death.

Skeletal Muscle Stem Cell Mitochondria Are Transferred to Muscle Fibers in Response to a Hypertrophic Stimulus

July 21, 2025

[Function] Researchers determined if muscle stem cells transfer their mitochondria upon myofiber fusion in response to a hypertrophic stimulus.

Leptin Aggravates Thoracic Aortic Dissection through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

July 16, 2025

[Advanced Science] Using leptin-knockout mice, investigators demonstrated that exogenous leptin exacerbates thoracic aortic dissection by promoting phenotypic transitions in vascular smooth muscle cells.

Dusp14-Mediated Dephosphorylation of MLKL Protects Against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure

July 7, 2025

[Circulation] Scientists addressed the urgent need to explore the pathologic mechanism of hypothyroidism-induced heart failure in detail and to discover and develop drugs that can target and manage heart failure in patients with hypothyroidism.

Allogenic Mitochondria Transfer Improves Cardiac Function in iPS-Cell-Differentiated Cardiomyocytes of a Patient With Barth Syndrome

July 7, 2025

[Experimental & Molecular Medicine] Investigators explored the possibility of using stem-cell-derived cardiomyocytes as a source of mitochondrial transplantation to treat Barth syndrome.

Cardiomyocyte-Derived YOD1 Promotes Pathological Cardiac Hypertrophy by Deubiquitinating and Stabilizing STAT3

July 7, 2025

[Science Advances] Scientists observed that the deubiquitinating enzyme YOD1 was moderately elevated in human hypertrophic myocardium and mouse models. Cardiomyocyte-specific knockout of YOD1 reduced Ang II– and TAC-induced cardiac hypertrophy.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.