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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Brain-Muscle Communication Prevents Muscle Aging by Maintaining Daily Physiology
[Science] Scientists examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, they created a basic clock module involving a central and a peripheral clock.
PPMD Awards $250,000 to Support Clinical Research Network for Duchenne Babies Identified by Newborn Screening
[Parent Project Muscular Dystrophy (PPMD)] PPMD announced a $250,000 award to Bo Hoon Lee, MD, from the University of Rochester to support the development of a clinical research network for Duchenne babies identified through newborn screening efforts in New York State.
Recent Trends in 3D Bioprinting Technology for Skeletal Muscle Regeneration
[Acta Biomaterialia] Investigators discuss existing treatment strategies following muscle damage, recent progress in bioprinting techniques, the bioinks used for muscle regeneration, the immunogenicity of scaffold materials, and in vitro and in vivo maturation techniques for 3D bio-printed muscle constructs.
CircNCX1 Modulates Cardiomyocyte Proliferation through Promoting Ubiquitination of BRG1
[Cellular Signalling] The authors reported that circNCX1, the most abundant circular RNA in mammalian hearts, could affect the proliferation of murine cardiomyocytes.
Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm
[Circulation Research] Genome-wide RNA sequencing analysis was performed on the aorta isolated from saline or angiotensin II–induced abdominal aortic aneurysm (AAA) mice, and activating transcription factor (ATF) 3 was identified as the potential key gene for AAA development.
Targeting Cardiomyocyte Cell Cycle Regulation in Heart Failure
[Basic Research In Cardiology] Investigators provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure.
The Mediator Med23 Controls a Transcriptional Switch for Muscle Stem Cell Proliferation and Differentiation in Muscle Regeneration
[Cell Reports] Investigators showed that the Mediator Med23 was critically important for muscle stem cell (MuSC)-mediated muscle regeneration. Med23 was increasingly expressed in activated/proliferating MuSCs on isolated myofibers or in response to muscle injury.
Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease
[Circulation] The authors used smooth muscle cell (SMC) lineage tracing mice and human tissues and applied a range of methods, including molecular, cellular, histological, computational, human genetics, and pharmacological approaches, to investigate the features of SMC-derived cells in atherosclerosis.
LSD1 Inhibition Circumvents Glucocorticoid-Induced Muscle Wasting of Male Mice
[Nature Communications] Researchers showed that glucocorticoid receptor (GR) and the lysine-specific demethylase 1 (LSD1) interact in myofibers of male mice, and that LSD1 connected GR-bound enhancers with NRF1-associated promoters to stimulate target gene expression.
Mechanical Stimulation of Induced Pluripotent Stem Derived Cardiac Fibroblasts
[Scientific Reports] The authors confirmed that iPSC-cardiofibroblasts (CFs) were comparable to primary CFs at gene, protein and functional level. Furthermore, iPSC-derived CFs adopted a pro-fibrotic response to transforming growth factor beta.
Differential Sex-Dependent Susceptibility to Diastolic Dysfunction and Arrhythmia in Cardiomyocytes from Obese Diabetic HFpEF Model
[Cardiovascular Research] Investigators performed echocardiography, electrophysiology, intracellular Ca2+ imaging, and protein analysis. Female heart failure with preserved ejection fraction (HFpEF) mice exhibited more severe diastolic dysfunction.
Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells
[American Journal Of Physiology-Cell Physiology] To assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells and isolated mitochondria, researchers performed respiratory and metabolic studies in wildtype and CRISPR-generated GOT2 knockdown C2C12 myocytes.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
