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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Multi-Omics Elucidation of Recombinant Collagen‐Mediated Modulation of Mesenchymal Stem Cell Functions
[Journal of Advanced Research] Scientists investigated how recombinant collagens modulate MSC behavior and paracrine functions to inform the development of bioactive scaffolds for tissue regeneration.
Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration
[Advanced Healthcare Materials] Researchers compared the endometrial matrix from specific human menstrual cycle and explored its therapeutic potential as a supportive biomaterial for endometrial MSC to enhance endometrial regeneration.
Late Embryogenesis Abundant Protein 3-Modified Human Umbilical Cord Mesenchymal Stem Cell Sheet Exhibits Antifreeze Properties
[International Journal of Biological Macromolecules] Investigators demonstrated that the late embryogenesis abundant protein-modified human umbilical cord MSCs sheet exhibits antifreeze properties, which provides a technological basis for the establishment of a cell sheet storage bank.
Pulmonary Delivery of TCR Bispecific Proteins via Mesenchymal Stem Cells Facilitates Efficient Clearance of Lung Cancers
[Cancer Science] Scientists demonstrated that T cell receptor bispecific proteins exhibit substantial cytotoxic activity against a variety of lung cancer cell lines. MSCs, with optimal pulmonary targeting properties, were shown to persist within the lungs for over 7 days.
Cardiomyocyte Pyroptosis Inhibited by Dental Pulp-Derived Mesenchymal Stem Cells via the Mir-19a-3p/IRF-8/MAPK Pathway in Ischemia-Reperfusion
[Chinese Medical Journal] Researchers determined the therapeutic effects of dental pulp-derived-MSCs on ischemia-reperfusion injury and elucidated the underlying mechanism.
Antifungal Efficacy of 3D-Cultured Palatal Mesenchymal Stem Cells and Their Secreted Factors against Candida albicans
[ACS Infectious Diseases] The authors underscored a perspective on the potent antifungal activity of secreted factors from palatal adipose tissue-derived-MSCs cultured within a 3D hydrogel matrix, specifically against various strains of C. albicans.
Recipient Periodic Fasting Promotes Osteogenesis of Implanted Mesenchymal Stromal Cell Aggregates and Safeguards Diabetic Mandibular Bone Regeneration
[Stem Cell Reviews and Reports] Using a high-fat diet-induced type 2 diabetes mellitus murine model, scientists revealed that cell aggregate implantation fails to boost osteogenesis or restore mandibular bone defects in diabetic mice due to systemic metabolic dysregulation.
Human Amniotic Mesenchymal Stem Cell-Derived Exosome Inhibits Ferroptosis through the Suppression of JNK/MAPK-Mediated EGR1 Expression in Spontaneous Intracerebral Hemorrhage
[Brain Research Bulletin] In vivo and in vitro functional experiments demonstrated the effectiveness of human amniotic MSC-exosome therapy in intracerebral hemorrhage models by reducing the level of ferroptosis, apoptosis, and inflammatory factors and restoring the neurological function.
Increased Efficacy of Adipose-Derived Mesenchymal Stem Cells Transduced with Klotho in Differentiation and Maturation of Oligodendrocytes in a Mouse Model of Experimental Autoimmune Encephalomyelitis
[Journal of Neuropathology and Experimental Neurology] Scientists investigated the therapeutic potential of MSCs engineered with secreted klotho in enhancing remyelination by mature oligodendrocytes in an experimental autoimmune encephalomyelitis model in mice.
Natural Polyphenols and Mesenchymal Stem Cells: A New Insight in Bone Regenerative Medicine
[Stem Cells International] The authors synthesize current insights into the interaction between MSCs and natural flavonoids, detailing the molecular mechanisms driving their synergistic effects.
DoD-Funded Stem Cell Trial Expands in Texas to Treat Traumatic Brain Injury
[Hope Biosciences (Business Wire)] Enrollment has opened at UTHealth San Antonio for a 51-participant, FDA-authorized double-blind placebo-controlled Phase II clinical trial to evaluate if intravenously infused Hope Biosciences autologous, adipose-derived MSCs affect brain structure, neurocognitive and functional outcomes, and/or neuroinflammation after traumatic brain injury in adults.
Mesenchymal Stromal Cell Secretome-Induced Synaptogenesis Is Mediated by Thrombospondin-1
[iScience] Using neuronal primary cultures, hippocampal organotypic slices, and human cortical brain organoids, researchers found that MSC secretome induces presynaptic differentiation.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
