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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Nasal Mucosal Mesenchymal Stem Cells Promote Repair of Sciatic Nerve Injury in Rats by Modulating the Inflammatory Microenvironment
[Neuroscience Letters] In vitro, ectodermal mesenchymal stem cells were found to enhance M2 macrophage polarization and the production of anti-inflammatory factors.
Developmental Dynamics Mimicking Inversely Engineered Pericellular Matrix for Articular Cartilage Regeneration
[Biomaterials] Investigators demonstrated the feasibility of using a pericellular matrix-mimicking system to improve MSC chondrogenesis and the efficacy of articular cartilage repair.
Long-Term Effect and Safety of Mesenchymal Stromal Cell Therapy for Radiation-Induced Hyposalivation in Head and Neck Cancer Survivors: A Randomised, Phase-II, Trial
[Clinical Cancer Research] The long-term effect of adipose-derived mesenchymal stromal cells to restore radiation-induced salivary gland hypofunction in previous head and neck cancer patients was investigated.
Msx1-Modified Rat Bone Marrow Mesenchymal Stem Cell Therapy for Rotator Cuff Repair: A Comprehensive Analysis of Tendon-Bone Healing and Cellular Mechanisms
[Journal of Orthopaedic Research] Scientists suggested that Msx1 modification enhances BMSC-mediated repair by promoting cell proliferation and migration, facilitating tendon-bone integration.
Biodegradable PHBVHHx-PEG/Collagen Hydrogel Scaffolds for Cartilage Repair
[Tissue Engineering Part A] Researchers demonstrated that PHBVHHx-COL scaffolds loaded with peripheral blood-derived MSCs significantly promoted the repair of cartilage injury through immune regulation by M2 polarization and could be potential candidates for cartilage tissue engineering.
Galvanic Cell-Stimulated Mesenchymal Stem Cell Mesh for Enhanced Pelvic Organ Prolapse Treatment
[Advanced Healthcare Materials] A fully degradable mesh is designed for the treatment of pelvic organ prolapse, utilizing MSCs stimulated by a galvanic battery-powered electric field.
Depleting Chemoresponsive Mitochondrial Fission Mediator DRP1 Does Not Mitigate Sarcoma Resistance
[Life Science Alliance] Scientists demonstrated that the expression and activation of the mitochondrial fission mediator dynamin-related protein 1 (DRP1) were affected by chemotherapy exposure in common pediatric sarcomas, namely, rhabdomyosarcoma and osteosarcoma.
Clinical Challenges in Bone Tissue Engineering – a Narrative Review
[Bone] The authors emphasize the impact of patient-specific factors on bone healing outcomes and the importance of personalized approaches. .
Atg5-Deficient Mesenchymal Stem Cells Protect against Non-Alcoholic Fatty Liver by Accelerating Hepatocyte Growth Factor Secretion
[Cell Communication and Signaling] In vitro, lentiviral transduction was employed to downregulate Atg5 or hepatocyte growth factor in human adipose-derived MSCs using short hairpin RNA.
Targeting RBM39 Suppresses Tumor Growth and Sensitizes Osteosarcoma Cells to Cisplatin
[Oncogene] The authors identified the RNA-binding protein RBM39 as a promising therapeutic target for osteosarcoma. RBM39 was essential for cell viability, and a higher expression of RBM39 was associated with poor prognosis in osteosarcoma.
Amniotic Fluid-Derived Stem Cells: Potential Factories of Natural and Mimetic Strategies for Congenital Malformations
[Stem Cell Research & Therapy] Scientists presented naturally occurring exosomes isolated from amniotic fluid-derived MSCs and their mimetic analogs as viable, reproducible, and stable alternatives.
iPSC-Derived Mesenchymal Stromal Cells Stimulate Neovascularization Less than Their Primary Counterparts
[Life Sciences] Researchers used a microfluidic organ-on-a-chip platform designed for vascularization assays to study and compare the effects of bone marrow MSCs and iPSC-derived MSCs in stimulating the formation of vessels by endothelial cells.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
