Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Subscribe|Follow Us On

Intracavernosal Mesenchymal Stem Cell Therapy in Ischemic Priapism: An Experimental Study

November 1, 2024

[International Urology and Nephrology] 30 male Wistar albino rats were divided into three groups: sham, priapism, and priapism + MSC treatment. The experimental groups were also divided into 1 and 12 hour subgroups of ischaemic priapism.

Mesenchymal Stromal Cells Can Block Palmitate Training of Macrophages via COX-2 and IL-1Ra

October 31, 2024

[Cytotherapy] Investigators showed that palmitate training of murine bone-marrow derived macrophages and human monocyte-derived macrophages resulted in an increased production of TNFα and IL-6 upon stimulation with lipopolysaccharide and was associated with epigenetic remodeling.

Aging Alters the Effect of Adiponectin Receptor Signaling on Bone Marrow-Derived Mesenchymal Stem Cells

October 29, 2024

[Aging Cell] Scientists observed differential expression of adiponectin receptors in the bone marrow of aged mice, characterized by elevated levels of adiponectin receptor 2 and reduced levels of receptor 1, as corroborated by both single-cell sequencing and in vivo staining.

S-RBD-Modified and miR-486-5p-Engineered Exosomes Derived from Mesenchymal Stem Cells Suppress Ferroptosis and Alleviate Radiation-Induced Lung Injury and Long-Term Pulmonary Fibrosis

October 29, 2024

[Journal of Nanobiotechnology] The authors developed an engineered MSC-derived exosomes with SARS-CoV-2-S-RBD- and miR-486-5p- modification and investigated their intervention effects on radiation-induced lung fibrosis and action mechanisms via suppression of epithelial cell ferroptosis.

Spatial Dimension Cues Derived From Fibrous Scaffolds Trigger Mechanical Activation to Potentiate the Paracrine and Regenerative Functions of MSCs via the FAK-PI3K/AKT Axis

October 29, 2024

[Acta Biomaterialia] The 3D fibrous constructs exhibiting well-defined topology with distinct spatial dimensions were fabricated using melt electro-writing to elucidate the effects of spatial dimension cues on the paracrine and regenerative functions of adipose-derived-MSCs.

BMP3b Regulates Bone Mass by Inhibiting BMP Signaling

October 29, 2024

[Bone] Investigators showed that bone morphogenetic protein 3b (BMP3b) deletion in mice led to a high bone mass phenotype via an unexpected novel mechanism involving de-repression of canonical BMP/Smad signaling.

Fusion of Breast Cancer MCF-7 Cells with Mesenchymal Stem Cells Rearranges Interallelic Gene Expression and Enhances Cancer Malignancy

October 29, 2024

[Biochemical and Biophysical Research Communications] Researchers reported changes in cell proliferative capacity, cell motility, anticancer drug resistance, and gene expression profiles when fusing human MCF-7 breast cancer cells and MSCs.

USP13 Overexpression in BMSCs Enhances Anti-Apoptotic Ability and Guards against Methylprednisolone-Induced Osteonecrosis in Rats

October 29, 2024

[Stem Cells] In a rat model of methylprednisolone-induced osteonecrosis of the femoral head, the authors evaluated the effects of USP13 overexpression in bone marrow MSCs through micro-CT, HE staining, and TUNEL staining.

Intrauterine Adhesions Repair with Menstrual Blood-Derived Mesenchymal Stem Cells via CXCL13-CXCR5 Signal Axis and Its Mechanism

October 29, 2024

[Stem Cell Research & Therapy] To evaluate the therapeutic effects of MSCs in intrauterine adhesions, investigators cultivated MSCs, established mouse endometrial injury model, observed the uterine morphology and degree of endometrial fibrosis and compared the expression of CXCL13, CXCR5, Pai-1, TGF- β1, and Mmp-9 among each groups.

Evaluating the Therapeutic Potential of Different Sources of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome

October 29, 2024

[Stem Cell Research & Therapy] Scientists investigated which sources of MSC: bone marrow derived-MSCs, adipose tissue derived-MSCs, and umbilical cord derived-MSCs would be the optimal candidate to be used as a therapy in an lipopolysaccharide-induced mouse model of acute respiratory distress syndrome.

Bazi Bushen Attenuates Osteoporosis in SAMP6 Mice by Regulating PI3K-AKT and Apoptosis Pathways

October 29, 2024

[Journal of Cellular and Molecular Medicine] The senescence-accelerated mouse prone 6 (SAMP6) model was used to explore bone homeostasis and treated intragastrically for nine weeks with Bazi Bushen.

Wnt/β-Catenin Signaling Pathway: Proteins’ Roles in Osteoporosis and Cancer Diseases and the Regulatory Effects of Natural Compounds on Osteoporosis

October 29, 2024

[Molecular Medicine] The authors summarize the effect of Wnt/β-catenin signaling pathway on osteoblast differentiation and the correlation between the related proteins in the pathway and human diseases.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.