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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Depleting Chemoresponsive Mitochondrial Fission Mediator DRP1 Does Not Mitigate Sarcoma Resistance
[Life Science Alliance] Scientists demonstrated that the expression and activation of the mitochondrial fission mediator dynamin-related protein 1 (DRP1) were affected by chemotherapy exposure in common pediatric sarcomas, namely, rhabdomyosarcoma and osteosarcoma.
Clinical Challenges in Bone Tissue Engineering – a Narrative Review
[Bone] The authors emphasize the impact of patient-specific factors on bone healing outcomes and the importance of personalized approaches. .
Atg5-Deficient Mesenchymal Stem Cells Protect against Non-Alcoholic Fatty Liver by Accelerating Hepatocyte Growth Factor Secretion
[Cell Communication and Signaling] In vitro, lentiviral transduction was employed to downregulate Atg5 or hepatocyte growth factor in human adipose-derived MSCs using short hairpin RNA.
Targeting RBM39 Suppresses Tumor Growth and Sensitizes Osteosarcoma Cells to Cisplatin
[Oncogene] The authors identified the RNA-binding protein RBM39 as a promising therapeutic target for osteosarcoma. RBM39 was essential for cell viability, and a higher expression of RBM39 was associated with poor prognosis in osteosarcoma.
Amniotic Fluid-Derived Stem Cells: Potential Factories of Natural and Mimetic Strategies for Congenital Malformations
[Stem Cell Research & Therapy] Scientists presented naturally occurring exosomes isolated from amniotic fluid-derived MSCs and their mimetic analogs as viable, reproducible, and stable alternatives.
iPSC-Derived Mesenchymal Stromal Cells Stimulate Neovascularization Less than Their Primary Counterparts
[Life Sciences] Researchers used a microfluidic organ-on-a-chip platform designed for vascularization assays to study and compare the effects of bone marrow MSCs and iPSC-derived MSCs in stimulating the formation of vessels by endothelial cells.
S-Nitrosylation of NOTCH1 Regulates Mesenchymal Stem Cells Differentiation Into Hepatocyte-Like Cells by Inhibiting Notch Signalling Pathway
[Journal of Cellular and Molecular Medicine] Investigators demonstrated that suppression of the intracellular domain release of the Notch pathway receptor via N-[(3, 5-difluorophenyl)acetyl]-L-alanyl-2-phenylglycine-1, 1-dimethylethyl ester significantly promoted the expression of hepatocyte-related genes and proteins in hepatocyte-like cells.
A Hierarchically Porous and SLIT3-Releasing Scaffold for Bone Tissue Engineering Applications
[Journal of Materials Science] Scientists reported producing a functionalized and hieratically porous bone scaffold that significantly supported cell adhesion and proliferation by providing bone mimicry structure and controlled release of protein.
Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells Ameliorate Ischemic Brain Injury in Mice by Regulating AAK1 via miR-664a-5p
[International Journal of Neuroscience] Researchers utilized a mouse model of middle cerebral artery occlusion and treated mice with umbilical cord MSCs derived exosomes.
Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Promote the Repair of Endometrial Injury via the miR-21-5p/PTEN/AKT Axis
[Stem Cells International] To observe the distribution of exosomes (Exos) in vivo, DIR-labeled human umbilical cord MSC-Exos were injected into the tail vein of endometrium-injured mice. The recovery of mice damaged endometrium after exosome treatment was detected by hematoxylin–eosin, TUNEL staining, and immunohistochemistry.
Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Focus on Inflammatory Bowel Disease
[Clinical and Translational Medicine] The authors provide a comprehensive examination of the therapeutic efficacy of MSC-extracellular vesicles in inflammatory bowel disease, with a focus on their mechanisms of action and potential impact on treatment outcomes.
CHEO Research Institute and Shriners Hospitals for Children Canada Collaborate to Launch First-of-Its-Kind Joint Pediatric Metabolic and Genetic Bone Disorders Fellowship
[Shriners Hospitals for Children Canada] Shriners Hospitals for Children Canada, in collaboration with Children's Hospitals of Eastern Ontario Research Institute, announced the launch of a joint pediatric metabolic and genetic bone disorders fellowship.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
