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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells
[Advanced Healthcare Materials] Cell differentiation was reported using a spatial geometric platform that could periodically modulate complex mechanical forces through a custom-made soft pneumatic device to mimic the interfaces between periosteum and interstitial fluid.
Cellular Sentinels: Empowering Survival and Immune Defense in Hematopoietic Stem Cell Transplantation through Mesenchymal Stem Cells and T Lymphocytes
[BMC Medicine] Scientists explored the combined infusion of allotype-cord blood hematopoietic stem cells and activated T cells from the same donor along with third-party MSCs.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Improve Thymus and Spleen Functions in D-Galactose-Induced Aged Mice
[Scientific Reports] Researchers investigated the potential of umbilical cord MSCs to mitigate d-galactose-induced immune senescence by enhancing the structural and functional integrity of aging immune organs and regulating the gut microbiota.
YAP1 Is a Key Regulator of EWS::FLI1-Dependent Malignant Transformation upon IGF-1-Mediated Reprogramming of Bone Mesenchymal Stem Cells
[Cell Reports] Investigators reported that transient exposure to insulin-like growth factor (IGF)-1 concentrations mimicking serum levels during puberty reprogrammed limb-derived mesenchymal cells of EWS::FLI1-mutant mice to stable transformation and tumorigenicity.
Organelle-Tuning Condition Robustly Fabricates Energetic Mitochondria for Cartilage Regeneration
[Bone Research] The authors demonstrated a highly efficient mitochondria-producing strategy by manipulating mitobiogenesis and tuning organelle balance in human MSCs.
Depletion of SUN1/2 Induces Heterochromatin Accrual in Mesenchymal Stem Cells during Adipogenesis
[Communications Biology] Researchers tested the hypothesis that severing of the nucleoskeleton and cytoskeleton complex-mediated cytoskeletal connections may have different effects on chromatin organization and MSC differentiation than those due to ablation of Sad1 and UNC-84 (SUN) proteins.
Adhesion-Assisted Antioxidant-Engineered Mesenchymal Stromal Cells for Enhanced Cardiac Repair in Myocardial Infarction
[ACS Nano] Investigators demonstrated that chemical modification of MSCs with anti-VCAM1 and polydopamine significantly enhanced MSC survival and promoted cardiac repair.
Aged and BRCA Mutated Stromal Cells Drive Epithelial Cell Transformation
[Cancer Discovery] Scientists reported that an epigenetically altered MSC niche, termed high risk MSC, existed prior to serous tubal intraepithelial carcinoma lesion formation.
Human Stem Cells with in Vivo High Plasticity Generated by Cell-Cell Communication
[Proceedings of The National Academy of Sciences of The United States of America] Scientists described the derivation of human adult high-plasticity stem cells, which they called guide-integrated adult stem cells, from the interaction of blood-derived guide cells and umbilical cord tissue–derived MSCs.
Engineered Mesenchymal Stromal Cells with Bispecific Polyvalent Peptides Suppress Excessive Neutrophil Infiltration and Boost Therapy
[Science Advances] Scientists engineered MSCs with P-selectin and E-selectin targeting peptides, assembling them into bispecific polyvalent structures using DNA self-assembly technology. This modification allowed engineered MSCs to compete with chemotactic neutrophils for selectin binding sites on endothelial cells.
New York Blood Center Enterprises and Human Life CORD Sign Letter of Intent to Expand Manufacturing Collaboration for Umbilical Cord -Derived Mesenchymal Stromal Cells
[NYBCe] New York Blood Center Enterprises (NYBCe) and Human Life CORD Japan Inc. have signed a Letter of Intent to expand their manufacturing collaboration for MSCs. This partnership aims to enhance the global supply chain for next-generation umbilical cord tissue-derived MSCs.
ENCell’s EN001 Receives Orphan Drug Designation from the US FDA for Charcot-Marie-Tooth Disease
[ENCell (BusinessWire)] ENCell announced that its investigational drug EN001 has been granted Orphan Drug Designation by the US FDA for the treatment of Charcot-Marie-Tooth disease. EN001 is a MSC therapy that enhanced cell longevity and optimized the secretion of therapeutic molecules required for treatment.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
