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Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
An Optimized Droplet Digital PCR Assay for HER2 Copy Number Variation in Breast Cancer Based on Multi-Reference Genes
[Applied Biochemistry and Biotechnology] To more accurately and objectively assess the HER2 amplification status of formalin fixed paraffin embedded samples, a droplet digital PCR assay based on multi-reference genes was developed.
Enhancing Photothermal Therapy against Breast Cancer Cells by Modulating the End Point of Gold Shell-Isolated Nanoparticles Using Nanostraw-Assisted Injection
[ACS Applied Materials & Interfaces] Investigators demonstrated that nanostraw-assisted injection enhances the photothermal therapy efficacy of gold shell-isolated nanoparticles compared to the conventional incubation method, as evaluated in human breast cancer cell lines: adenocarcinoma cells and glandular carcinoma cells.
Enhanced Therapeutic Efficacy of Platinum-Doxorubicin Nanoparticles on Colon and Breast Cancer Cell Lines
[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists platinum nanoparticles were synthesized and their potential to improve the efficacy of doxorubicin in cancer treatment was investigated.
Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance
[Advanced Science] Researchers showed that nuclear-localized branched-chain α-ketoacid dehydrogenase kinase (BCKDK) acts as a modulator of homologous recombination repair, promoting cell resistance against DNA damage-inducing therapy in breast cancer.
Discovery and Biological Evaluation of a Novel and Highly Potent JAK2 Inhibitor for the Treatment of Triple Negative Breast Cancer
[Journal of Enzyme Inhibition and Medicinal Chemistry] Investigators discovered six JAK2 inhibitors using structure-based virtual screening and molecular docking and demonstrated that JNN-5 may be a highly effective and selective antitumor compound for the treatment of TNBC.
SDCBP/Syntenin-1 Stabilizes BACH1 by Disassembling the SCFFBXO22-BACH1 Complex in Triple-Negative Breast Cancer
[EMBO Journal] Scientists demonstrated that SDCBP, a tandem-PDZ-domain protein, stabilized BACH1 by disassembling the Skp1-Cullin1-FBXO22 (SCFFBXO22)-BACH1 complex via a heme/heme-oxygenase-1-independent manner in TNBC cells.
PAK5 Promotes the Trastuzumab Resistance by Increasing HER2 Nuclear Accumulation in HER2-Positive Breast Cancer
[Cell Death & Disease] Scientists showed that high expression of p21-activated kinase 5 (PAK5) was associated with HER2-targeted therapy resistance and poor outcomes of breast cancer patients.
G6PC3 Promotes Genome Maintenance and Is a Candidate Mammary Tumor Suppressor
[JCI Insight] Investigators searched for potential drivers based on germline DNA analysis from a cohort consisting of early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.
SNORA47 Affects Stemness and Chemotherapy Sensitivity via EBF3/RPL11/C-Myc Axis in Luminal a Breast Cancer
[Molecular Medicine] High SNORA47 expression was linked to unfavorable survival outcomes among patients with Luminal A breast cancer in The Cancer Genome Atlas.
Development of Silver-Based Hybrid Nanoparticles Loaded with eEF2 K-siRNA and Quercetin against Triple-Negative Breast Cancer
[Drug Delivery and Translational Research] Researchers developed a novel hybrid nanoparticle using a Layer-by-Layer (method for siRNA delivery targeting eukaryotic elongation factor 2 kinase (eEF2K) in TNBC.
FOXO1 Mediates Mir-99a-5p/E2F7 to Restrain Breast Cancer Cell Proliferation and Induce Apoptosis
[BMC Cancer] Scientists clarified how FOXO1 suppressed breast cancer cell proliferation and induced apoptosis.
Hyaluronic Acid-Coated Capecitabine Nanostructures for CD44 Receptor-Mediated Targeting in Breast Cancer Therapy
[RSC Advances] Hyaluronic acid-functionalized nanomicelles provided a biocompatible and efficient system for the targeted breast cancer therapy, enhancing the therapeutic efficacy of capecitabine.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
