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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Mucinous Breast Cancer Organoids: An In Vitro Research Model
[Discover Oncology] Scientists obtained surgical tumor samples from a 64-year-old Chinese female patient diagnosed with pure mucinous breast cancer to establish patient-derived organoids.
Prophylactic Irradiation of the Contralateral Breast for BRCA Carriers With Early Breast Cancer
[JAMA Oncology] Scientists reported the long-term results of a prospective nonrandomized Phase II trial of prophylactic radiation therapy to the contralateral breast in BRCA pathogenic variant carriers with early breast cancer who forego risk-reducing mastectomy.
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
[Cancer Research] The authors suggest that PIK3C3-peripheral lysosomal signaling to mTORC1 may represent a targetable axis for preventing dormant cancer cell–initiated metastasis in patients with breast cancer.
pH-Triggered Delivery of Pirarubicin-Gemcitabine Duo Using Polymeric Nanoparticles for Synergistic Breast Cancer Therapy
[Nanoscale Horizons] Researchers investigated the development of pirarubicin and gemcitabine co-loaded polymeric nanoparticles for synergistic activity against breast cancer cells.
TRA/MEL Immunoliposomes Act As a Targeted Medicine in BT-474 Breast Cancer Cells
[Journal of Liposome Research] Scientists explored the potential of targeted delivery of the gene encoding melittin using TRA-conjugated immunoliposomes to breast cancer cells as an effective treatment option with reduced side effects.
Toxicarioside H Induces Ferroptosis in Triple-Negative Breast Cancer Cells through Nrf2/HO-1 Pathway
[Discover Oncology] Investigators evaluated whether toxicarioside H has the capability of inducing ferroptosis in TNBC cells and elucidated the underlying molecular mechanisms.
OGT Enhances Adriamycin Resistance of Breast Cancer by Promoting Glycolysis through MDM4 Upregulation in an O-GlcNAcylation-Dependent Manner
[Biochemical Genetics] Researchers investigated the mechanism of O-GlcNAcylation-mediated adriamycin (ADR) resistance in breast cancer. Cell viability, proliferation, and apoptosis were performed to evaluate ADR resistance in breast cancer cells.
Nanomaterials for Delivery of Drugs and Genes to Disrupt Notch Signaling Pathway in Breast Cancer
[Naunyn-Schmiedebergs Archives of Pharmacology] The authors examine recent breakthroughs in nanocarrier systems aimed at the Notch signaling pathway in breast cancer, highlighting the therapeutic potential of integrating nanomedicine with Notch inhibition to disrupt epithelial-mesenchymal transition, tumor-initiating cells, and metastasis, thereby enhancing clinical outcomes.
City of Hope Urges Bold Action to Address Rise in Cancer Among Younger Women
[City of Hope (Business Wire)] With cancer rates in women under 50 now 82% higher than men, leading National Cancer Research and treatment organization calls for age-specific research, expanded risk assessments, and lifetime survivorship support.
CHD8 Interacts with BCL11A to Induce Oncogenic Transcription in Triple Negative Breast Cancer
[EMBO Journal] Scientists described their approach for the identification of TNBC-specific protein–protein interactions focusing on the oncogene BCL11A.
G Protein-Coupled Estrogen Receptor Reduces the Breast Cancer Cell Survival by Regulating the IRE1α/Mir-17-5p/ TXNIP Pathway
[The Journal of Steroid Biochemistry and Molecular Biology] Investigators explored whether G protein-coupled estrogen receptor 1 can induce the UPR response in the SKBR3 cell line through estrogen receptor and inositol-requiring enzyme 1 alpha activation, and to assess whether this response leads to cell survival or cell death.
Tubeimoside I Inhibits the Growth of Triple-Negative Breast Cancer via the NR3 C2/PI3 K/AKT Signaling Pathway
[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists used a comprehensive approach involving bioinformatics analysis and in vivo and in vitro experiments to investigate the effects of TBMS1 on triple-negative breast cancer (TNBC) cells and elucidated the underlying molecular mechanisms involved.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
