Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Neutrophil-Derived PAD4 Induces Citrullination of CKMT1 Exacerbates Mucosal Inflammation in Inflammatory Bowel Disease

May 13, 2024

[Cellular & Molecular Immunology] Scientists employed single-cell RNA sequencing and substrate citrullination mapping to decipher the role of peptidyl arginine deiminase 4 (PAD4) in intestinal inflammation associated with inflammatory bowel disease.

Mitochondrial Function and Gastrointestinal Diseases

May 13, 2024

[Nature Reviews Gastroenterology & Hepatology] The authors provide an overview of the current understanding of intestinal epithelial cell mitochondrial metabolism, function and signaling to affect tissue homeostasis, in addition to mitochondrial-targeted therapeutics for inflammatory bowel diseases and colorectal cancer.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

May 10, 2024

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

May 10, 2024

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

Cetuximab Inhibits Colorectal Cancer Development through Inactivating the Wnt/β-Catenin Pathway and Modulating PLCB3 Expression

May 9, 2024

[Scientific Reports] Scientists investigated the influence of PLCB3, a potential colorectal cancer (CRC) oncogene, on cetuximab treatment. In vitro tests revealed that cetuximab exerted a cytotoxic effect on CRC cells, with PLCB3 knockdown inhibiting CRC cell progression.

Fusobacterium nucleatum Infection Modulates the Transcriptome and Epigenome of HCT116 Colorectal Cancer Cells in an Oxygen-Dependent Manner

May 8, 2024

[Communications Biology] Using a multiomic approach, researchers analyzed epigenomic alterations of H3K27ac and global transcriptomic alterations sustained within a hypoxia and normoxia conditioned colorectal cancer cell line at 24 h following initial infection with F. nucleatum.

Circ-0075305 Hinders Gastric Cancer Stem Cells by Indirectly Disrupting TCF4–β-Catenin Complex and Downregulation of SOX9

May 8, 2024

[Communications Biology] In vitro and in vivo experiments confirmed that overexpression of Circ-0075305 could effectively reduce stem cell-like properties and enhanced the sensitivity of gastric cancer cells to Oxaliplatin compared with the control group.

Apoptotic Effect of 5-Fluorouracil-Doxorubicin Combination on Colorectal Cancer Cell Monolayers and Spheroids

May 6, 2024

[Molecular Biology Reports] The antiproliferative effects of 5-fluorouracil and doxorubicin were investigated separately and in combination using 2D and 3D cell culture models on two different colon cancer cell lines.

CEBPB-Mediated Upregulation of SERPINA1 Promotes Colorectal Cancer Progression by Enhancing STAT3 Signaling

May 6, 2024

[Cell Death Discovery] Researchers analyzed the prognostic value and clinical significance of serpin family a member 1 (SERPINA1) in colorectal cancer, and predicted potential transcription factors.

Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...

May 3, 2024

[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

Impact of the Thyroid Hormone T3 and its Nuclear Receptor TRα1 on Colon Cancer Stem Cell Phenotypes and Response to Chemotherapies

May 2, 2024

[Cell Death & Disease] Researchers used an established spheroid model generated from the human colon adenocarcinoma cell line Caco2 to study the effects of T3 and TRα1 on spheroid formation, growth, and response to conventional chemotherapies.

Baicalein Triggers Ferroptosis in Colorectal Cancer Cells via Blocking the JAK2/STAT3/GPX4 Axis

May 2, 2024

[Acta Pharmacologica Sinica] Scientists investigated whether baicalein, the primary flavone extracted from the dried roots of Scutellaria baicalensis induced ferroptosis in colorectal cancer cells.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.