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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor
[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.
Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists
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[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.
Takeda’s FRUZAQLATM (Fruquintinib) Publicly Reimbursed in Quebec for the Treatment of Metastatic Colorectal Cancer (mCRC)
[Takeda Canada, Inc. ] Takeda Canada, Inc. is pleased to announce that FRUZAQLATM will now be reimbursed by Régie de l’assurance maladie for people in Quebec, under certain criteria, as a treatment for adult patients with mCRCwho have been previously treated with, or are not considered candidates, for available standard therapies.
ACTL6A Depletion Induces KLF4-Mediated Anti-Tumorigenic Effects in Colorectal Cancer
[Cell Death & Disease] Integrated multi-omics analyses revealed that ACTL6A deficiency alters chromatin accessibility and upregulates p53 pathway-related genes, accompanied by the recruitment of SWI/SNF and INO80 complexes.
DJ-1 Counteracts Caveolin-1-Mediated Necroptosis to Inhibit Epithelial Barrier Dysfunction in Colitis
[Cell Death & Disease] Scientists delineated the involvement of caveolin-1 (CAV1) in murine models of dextran sulfate sodium-induced colitis. CAV1 knockout mice manifest attenuated pathological and inflammatory damage to the epithelium, whereas mice overexpressing CAV1 exhibit contrasting outcomes.
Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli
[Journal of Medicinal Chemistry] Researchers described their efforts, challenges, and compound evaluation workflow resulting in gut-restricted PRMT5 inhibitors.
Targeting Macrophage Migration Inhibitory Factor As a Potential Therapeutic Strategy in Colorectal Cancer
[Oncogenesis] Investigators depleted epithelial macrophage migration inhibitory factorduring late-stage colorectal cancer (CRC) tumorigenesis in two genetically-engineered and chemically-induced murine CRC models.
GDF15-Mediated Regulation of Ferroptosis: Unraveling the P62/Keap1/Nrf2 Pathway in Gastric Cancer Development
[Molecular Carcinogenesis] The authors investigated the role of Growth Differentiation Factor 15 (GDF15) in regulating ferroptosis through the p62/Keap1/Nrf2 pathway and to elucidate its impact on gastric cancer progression.
M5c RNA Modification in Colorectal Cancer: Mechanisms and Therapeutic Targets
[Journal of Translational Medicine] 5-methylcytosine (m5C) modification, an important epigenetic regulators in colorectal cancer, provides a new perspective on the mechanism underlying cancer therapy and precision medicine research.
A “Space-for-Time” Strategy Based on Single-Cell Dual-Isotope ICP-MS Analysis Enabling High-Throughput and Sensitive Quantification of miRNAs in Breast Cancer Cells for Therapeutic Assessment
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[Analytical Chemistry] Investigators focused on two key regulatory miRNAs in breast cancer therapeutic assessment and developed a “space-for-time” strategy using dual-isotope ICP-MS for single-cell miRNAs quantification.
Toripalimab, Bevacizumab, and Irinotecan in dMMR/MSI Locally Advanced Colorectal Cancer: First-Stage Results from a Phase Ib/II Trial
[Cell Reports Medicine] This was the first stage of the Phase Ib/II trial evaluating the effectiveness and safety of toripalimab, irinotecan, and bevacizumab in patients with rectal cancer refusing up-front surgery or radiation therapy and patients with T4NanyM0 colon cancer with deficiency of mismatch repair or microsatellite instability.
The Nα-Acetyl-L-Lysine/Loxl2/H2O2 Promotes Intestinal Tumor Growth in Drosophila and Cell Proliferation in Human Colorectal Cancer
[Cell Reports] Scientists showed that Staphylococcus sciuri promotes Drosophila intestinal tumor growth by inducing intestinal stem cell division.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
