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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Impact of the Thyroid Hormone T3 and its Nuclear Receptor TRα1 on Colon Cancer Stem Cell Phenotypes and Response to Chemotherapies
[Cell Death & Disease] Researchers used an established spheroid model generated from the human colon adenocarcinoma cell line Caco2 to study the effects of T3 and TRα1 on spheroid formation, growth, and response to conventional chemotherapies.
Baicalein Triggers Ferroptosis in Colorectal Cancer Cells via Blocking the JAK2/STAT3/GPX4 Axis
[Acta Pharmacologica Sinica] Scientists investigated whether baicalein, the primary flavone extracted from the dried roots of Scutellaria baicalensis induced ferroptosis in colorectal cancer cells.
Modeling the Cell Biology of Monogenetic Intestinal Epithelial Disorders
[Journal Of Cell Biology] The authors provide insight into monogenetic intestinal epithelial disorders, also known as congenital diarrheas and enteropathies (CODEs).
Vitamin D Opposes Multilineage Cell Differentiation Induced by Notch Inhibition and BMP4 Pathway Activation in Human Colon Organoids
[Cell Death & Disease] Investigators reported a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients.
Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers
[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.
Alzheimer’s Disease-Related Presenilins Are Key to Intestinal Epithelial Cell Function and Gut Immune Homoeostasis
[Gut] Scientists generated intestinal epithelium-specific Psen1-deficient, Psen2-deficient and inducible Psen1/Psen2 double-deficient mice to dissect the functional role of presenilins in intestinal homoeostasis.
CBX3 Antagonizes IFNγ/STAT1/PD-L1 Axis to Modulate Colon Inflammation and CRC Chemosensitivity
[EMBO Molecular Medicine] The authors revealed that the epigenetic regulator, chromobox protein homolog 3 (CBX3) antagonized IFNγ signaling in the colon epithelium by transcriptionally repressing two critical IFNγ-responsive genes: STAT1 and CD274.
Mitochondrial Genome Transfer Drives Metabolic Reprogramming in Adjacent Colonic Epithelial Cells Promoting TGFβ1-Mediated Tumor Progression
[Nature Communications] Scientists revealed that intact mitochondrial genome was enriched in serum extracellular vesicles from colon cancer patients and positively correlated with tumor stage.
Vitamin D Opposes Multilineage Cell Differentiation Induced by Notch Inhibition and BMP4 Pathway Activation in Human Colon Organoids
[Cell Death & Disease] Scientists reported a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients.
NAT10-Mediated ac4C Modification Promotes Stemness and Chemoresistance of Colon Cancer by Stabilizing NANOGP8
[Heliyon] The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.
LSD1 Drives Intestinal Epithelial Maturation and Controls Small Intestinal Immune Cell Composition Independent of Microbiota in a Murine Model
Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this...
Recent Progress on Engineered Micro/Nanomaterials Mediated Modulation of Gut Microbiota for Treating Inflammatory Bowel Disease
[Journal Of Controlled Release] The authors present the interactions among the immune system, intestinal barrier, and gut microbiome. In addition, recent advances in administration routes and methods that positively arouse the regulation of intestinal flora for inflammatory bowel disease using probiotics, prebiotics, and redox-active micro/nanomaterials have been reviewed.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
