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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Targeting SOX13 Inhibits Assembly of Respiratory Chain Supercomplexes to Overcome Ferroptosis Resistance in Gastric Cancer
[Nature Communications] Investigators showed that SOX13 boosted protein remodeling of electron transport chain complexes by directly transactivating SCAF1. This led to increased supercomplex assembly, mitochondrial respiration, mitochondrial energetics and chemo- and immune-resistance.
RAF1 Facilitates KIT Signaling and Serves as a Potential Treatment Target for Gastrointestinal Stromal Tumor
[Oncogene] Investigators reported that inhibition of RAF1 suppressed the activation of both wild-type KIT and primary KIT mutations in gastrointestinal stromal tumor, with primary KIT mutations showing greater sensitivity.
NUP43 Promotes PD-L1/nPD-L1/PD-L1 Feedback Loop via TM4SF1/JAK/STAT3 Pathway in Colorectal Cancer Progression and Metastatsis
[Cell Death Discovery] Scientists reported that the oncogenic factor nucleoporin 43 (NUP43) impacted the process of programmed cell death-ligand 1 (PD-L1) nuclear translocation by regulating the expression level of the PD-L1 chaperone protein Importin 5. This process could stimulate the expression of tumor-promoting factor transmembrane 4 L six family member 1 (TM4SF1) and further activated the JAK/STAT3 signaling pathway.
CytoReason and the Crohn’s & Colitis Foundation Forge Groundbreaking Data Collaboration to Advance IBD Research
[CytoReason] CytoReason announced a collaboration with the Crohn’s & Colitis Foundation. The collaboration aims to empower CytoReason’s analytical capabilities with the Foundation’s inflammatory bowel disease (IBD) Plexus® real-world data platform. This collaboration has the potential to accelerate new discoveries with superior data integration and improve the precision and effectiveness of drug development in IBD.
IL-22 Promotes Mucin-Type O-Glycosylation and MATH1+ Cell-Mediated Amelioration of Intestinal Inflammation
[Cell Reports] By using a range of intestinal epithelial cell type-specific conditional knockout mice and a dextran sulfate sodium colitis model, the authors demonstrated that IL-22Ra1 signaling in MATH1+ cells (goblet and progenitor cells) was essential for maintaining the mucosal barrier and intestinal tissue regeneration.
Patient Tissue-Derived FGFR4-Variant and Wild-Type Colorectal Cancer Organoid Development and Anticancer Drug Sensitivity Testing
[Heliyon] Fibroblast growth factor receptor 4 (FGFR4)-variant and wild-type colorectal cancer (CRC) organoids were developed to investigate the effects of FGFR4-targeted drugs on CRC and their possible molecular mechanism.
Metabolic Regulator ERRγ Governs Gastric Stem Cell Differentiation into Acid-Secreting Parietal Cells
[Cell Stem Cell] Using mouse models and human gastric cells, researchers identified the parietal cell progenitors arising from isthmal stem cells, and showed that they preferentially expressed cell-metabolism regulator and orphan nuclear receptor estrogen-related receptor gamma.
Protein Phosphatase 6 Activates NF-κB to Confer Sensitivity to MAPK Pathway Inhibitors in KRAS- and BRAF-Mutant Cancer Cells
[Science Signaling] To better understand the genetic pathways that modulate cancer cell sensitivity to Ras–mitogen-activated protein kinase (MAPK) pathway inhibitors, scientists performed a CRISPR knockout screen with MAPK pathway inhibitors on a colorectal cancer cell line carrying mutant KRAS.
HTRA1 Interacts with SLC7A11 to Modulate Colorectal Cancer Chemosensitivity by Inhibiting Ferroptosis
[Cell Death Discovery] HtrA serine protease 1 (HTRA1) was screened out as a colorectal cancer (CRC) progression- and chemoresistance-related gene. Gain- and loss-of-function analyses demonstrated a stimulatory role of HTRA1 on the proliferation of CRC cells.
Neutrophil-Derived PAD4 Induces Citrullination of CKMT1 Exacerbates Mucosal Inflammation in Inflammatory Bowel Disease
[Cellular & Molecular Immunology] Scientists employed single-cell RNA sequencing and substrate citrullination mapping to decipher the role of peptidyl arginine deiminase 4 (PAD4) in intestinal inflammation associated with inflammatory bowel disease.
Mitochondrial Function and Gastrointestinal Diseases
[Nature Reviews Gastroenterology & Hepatology] The authors provide an overview of the current understanding of intestinal epithelial cell mitochondrial metabolism, function and signaling to affect tissue homeostasis, in addition to mitochondrial-targeted therapeutics for inflammatory bowel diseases and colorectal cancer.
Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells
[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
