Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Dual Modulation of Cytotoxic and Checkpoint Receptors Tunes the Efficacy of Adoptive Delta One T Cell Therapy against Colorectal Cancer

April 21, 2025

[Nature Cancer] Investigators demonstrated the capacity of Delta One T cells to target colorectal cancer (CRC) cell lines and patient-derived specimens and organoids in vitro and to control tumor growth in an orthotopic xenograft model of CRC.

Phospholipase D6 Activates Wnt/β-catenin Signaling through Mitochondrial Metabolic Reprogramming to Promote Tumorigenesis in Colorectal Cancer

April 21, 2025

[Experimental & Molecular Medicine] Scientists found that phospholipase D6 (PLD6) was highly expressed in colorectal cancer (CRC) and positively correlated with poor prognosis. PLD6 depletion suppressed the oncogenic properties of CRC cells and impaired mitochondrial respiration, leading to reduced mitochondrial length and reactive oxygen species.

Male-Specific Lethal 1 (MSL1) Promotes Erastin-Induced Ferroptosis in Colon Cancer Cells by Regulating the KCTD12-SLC7A11 Axis

April 15, 2025

[Cell Death & Disease] Researchers provided evidence of a negative regulatory relationship between MSL1 and KCTD12 through biochemical assays and knockdown/overexpression studies.

Interactions between Polystyrene Nanoparticles and Human Intestinal Epithelial Caco-2 Cells

April 15, 2025

[Nanoimpact] Using 70 nm red fluorescent polystyrene as a nanoplastic model, scientists investigated the uptake, distribution, and exocytosis of nanoplastics in Caco-2 cells.

Camellia nitidissima Chi Extract Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice by Inhibiting TLR4/NF-κB-Mediated Inflammatory Activation

April 15, 2025

[Inflammopharmacology] Investigators explored the protective effects and mechanisms of the alcoholic extract of Camellia nitidissima Chi on dextran sulfate sodium-induced ulcerative colitis.

US FDA Approves Opdivo® (Nivolumab) Plus Yervoy® (Ipilimumab) As a Treatment for Patients with Previously Untreated Microsatellite Instability-High or Mismatch Repair Deficient Unresectable or...

April 11, 2025

[Bristol Myers Squibb] Bristol Myers Squibb announced that the US FDA approved Opdivo®plus Yervoy® as a first-line treatment of adult and pediatric patients with unresectable or metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer.

Neutrophil-Derived Serine Proteases Induce FOXA2-Mediated Autophagy Dysfunction and Exacerbate Colitis-Associated Carcinogenesis via F2RL1/Protease-Activated Receptor 2

April 11, 2025

[Autophagy] Researchers showed that F2R like trypsin receptor 1 (F2rl1)/Par2 deficiency aggravated azoxymethane-dextran sulfate sodium-induced colitis-associated colorectal cancer based on tumor number and burden, and promoted autophagy dysfunction characterized by SQSTM1/p62 accumulation.

Intestinal Secretory Differentiation Reflects Niche-Driven Phenotypic and Epigenetic Plasticity of a Common Signal-Responsive Terminal Cell

April 11, 2025

[Cell Stem Cell] Based on morphology, location, and canonical markers, goblet and Paneth cells were considered distinct secretory types. The authors reported high overlap in their transcripts and sites of accessible chromatin, in marked contrast to those of their enteroendocrine or tuft cell siblings.

SERPINE1 Facilitates Metastasis in Gastric Cancer through Anoikis Resistance and Tumor Microenvironment Remodeling

April 11, 2025

[Small] Researchers elucidated the mechanisms by which SERPINE1 mediated anoikis resistance and fostered an immunosuppressive tumor microenvironment in advanced gastric cancer.

Multimarker Assessment of B Cell and Plasma Cell Subsets and Their Prognostic Role in the Colorectal Cancer Microenvironment

April 9, 2025

[Clinical Cancer Research] Scientists assessed the characteristics and significance of various B cell and plasma cell subsets in colorectal tumors.

Genetic Variation at 11q23.1 Confers Colorectal Cancer Risk by Dysregulation of Colonic Tuft Cell Transcriptional Activator POU2AF2

April 9, 2025

[Gut] Researchers employed analysis of RNA sequencing, single-cell RNA sequencing, chromatin immunoprecipitation sequencing and single-cell ATAC sequencing data to identify, prioritize, and characterise the genes that contribute to colorectal cancer risk.

Direct Inhibition of the TXNIP-NLRP3-GSDMD Pathway Reduces Pyroptosis in Colonocytes and Alleviates Ulcerative Colitis in Mice by the Small Compound PEITC

April 7, 2025

[Acta Pharmacologica Sinica] Researchers evaluated the therapeutic potential of phenethyl isothiocyanate in the treatment of ulcerative colitis and the underlying mechanisms.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.