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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Immunogenicity and Safety of a Live-Attenuated SARS-CoV-2 Vaccine Candidate Based on Multiple Attenuation Mechanisms
[eLife] Researchers constructed a live-attenuated vaccine candidate, BK2102, combining naturally occurring virulence-attenuating mutations in the NSP14, NSP1, spike, and ORF7-8 coding regions.
Activation of CXCR3+ Tfh Cells and B Cells in Lymph Nodes During Acute HIV-1 Infection Correlates with HIV-Specific Antibody Development
[Journal of Virology] To understand how Tfh/GC B-cell interactions during acute HIV-1 infection (AHI) impact the generation of HIV-specific antibodies, researchers performed a unique cross-sectional analysis of inguinal lymph node biopsies taken prior to antiretroviral therapy initiation in AHI.
Necrosis Drives Susceptibility to Mycobacterium tuberculosis in PolgD257A Mutator Mice
[Infection and Immunity] The authors reported that mutations in mitochondria DNA polymerase gamma potentiate susceptibility to Mycobacterium tuberculosis infection in mice.
Systemic Inflammation Is Associated with Worse Outcomes from SARS-CoV-2 Infection but Not Neutralizing Antibody
[Microbiology Spectrum] Scientists determined the association between neutralizing antibody responses, inflammation, and clinical outcomes in hospitalized patients with COVID-19.
Mycobacterium bovis Mb3523c Protein Regulates Host Ferroptosis via Chaperone-Mediated Autophagy
[Autophagy] Investigators demonstrated that the mammalian cell entry 4 family protein Mb3523c triggerred ferroptosis to promote M. bovis pathogenicity and dissemination.
PCSK9 Potentiates Innate Immune Response to RNA Viruses by Preventing AIP4-Mediated Polyubiquitination and Degradation of VISA/MAVS
[Proceedings of The National Academy of Sciences of The United States of America] Scientists identified secreted proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibited sendai virus and vesicular stomatitis virus infection, while intracellular PCSK9 served as a positive regulator of RNA virus-triggered innate immune response.
Deep Profiling of B Cells Responding to Various Pathogens Uncovers Compartments in IgG Memory B Cell and Antibody-Secreting Lineages
[Science Advances] Investigators compared prepandemic antigen responses with recently encountered SARS-CoV-2 antigen responses in convalescent COVID-19 patients using spectral flow cytometry.
Druggable Genome Screens Identify SPP as an Antiviral Host Target for Multiple Flaviviruses
[Proceedings of The National Academy of Sciences of The United States of America] Researchers developed a CRISPR/Cas9 library targeting the druggable genome and identified signal peptide peptidase (SPP) as a critical host target for several flaviviruses.
Translational Lessons from the Balanced Immune System in Bats
[Disease Models & Mechanisms] The authors focus on the mechanism of immunity balance in bats, the application of omics and how this might lead to improvement of human health.
Seed Grant Funding Awarded to Six Collaborative Projects
[Washington State University] Washington State University (WSU) Health Sciences and Seattle Children’s Research Institute awarded six collaborative projects $300,000 in seed grant funding following an inaugural joint symposium between the two institutions this fall at WSU Spokane.
Akkermansia muciniphila Identified as Key Strain to Alleviate Gut Barrier Injury through Wnt Signaling Pathway
[eLife] Researchers showed that fecal microbiota transplantation regulated gut microbiota and enhanced the protection of AIMD piglets against Escherichia coli K88 challenge, as demonstrated by reduced intestinal pathogen colonization and alleviated gut barrier injury.
TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review
[BioDrugs] The authors review the role of TL1A in inflammatory bowel disease, evaluate the efficacy of anti-TL1A therapies in clinical trials, and discuss future directions for research and treatment.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
