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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
THEMIS Promotes T Cell Development and Maintenance by Rising the Signaling Threshold of the Inhibitory Receptor BTLA
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that the T cell lineage protein THEMIS operates as a rheostat which restrain the signaling capacity the inhibitory receptor B- and T-lymphocyte attenuator (BTLA).
Triune Nanomodulator Enables Exhausted Cytotoxic T Lymphocyte Rejuvenation for Cancer Epigenetic Immunotherapy
[ACS Nano] Scientists presented a well-designed triune nanomodulator, termed ROCA, which demonstrated robust capabilities in tumor epigenetic modulation and immune microenvironment reprogramming for cancer epigenetic immunotherapy.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, researchers identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, investigators identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
Thymocyte Migration and Emigration
[Immunology Letters] Investigators review the contribution of the key factors mentioned above for the localization, migration and emigration of thymocytes.
Traverse Biotech Awarded Phase I SBIR Grant by the National Institute of Allergy and Infectious Diseases for Development of Innate Immune Stimulator
[Traverse Biotech, Inc. (PR Newswire)] Traverse Biotech, Inc. has been awarded a Phase I Small Business Innovation Research grant from the National Institute of Allergy and Infectious Diseases, part of the NIH.
ABBV-319: A CD19-Targeting Glucocorticoid Receptor Modulator Antibody-Drug Conjugate Therapy for B Cell Malignancies
[Blood] ABBV-319 elicited potent glucocorticoid receptor modulator-driven anti-tumor activity against multiple malignant B cell lines in vitro as well as in cell line-derived xenografts and patient-derived xenografts in vivo.
Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancer Tumors
[Cancer Immunology Research] Scientists showed JHU083-mediated glutamine antagonism in tumor microenvironments induced TNF, pro-inflammatory, and mTORC1 signaling in intratumoral tumor-associated macrophages clusters.
ALOX15+ M2 Macrophages Contribute to Epithelial Remodeling in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
[Journal Of Allergy And Clinical Immunology] Researchers investigated the role of ALOX15+ M2 macrophages in the epithelial remodeling of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). Digital spatial transcriptome and single-cell sequencing analyses were used to characterize the epithelial remodeling and cellular infiltrate in eCRSwNP.
Allergen Immunotherapy: The Evidence Supporting the Efficacy and Safety of Subcutaneous Immunotherapy and Sublingual Forms of Immunotherapy for Allergic Rhinitis/Conjunctivitis and Asthma
[Journal Of Allergy And Clinical Immunology-In Practice] The authors review the evidence-based literature supporting the use of these forms of allergen immunotherapy (AIT), as well as focus on several current controversies and gaps in our knowledge base that have relevance for the appropriate selection of patients for treatment with specific AIT.
CPT-11 Mitigates Autoimmune Diseases by Suppressing Effector T Cells Without Affecting Long-Term Anti-Tumor Immunity
[Cell Death Discovery] Researchers showed that CPT-11 suppresses T cell proliferation and pro-inflammatory cytokine production in healthy C57BL/6 mice and in complete Freund’s adjuvant-challenged mice.
Urban Indoor Gardening Enhances Immune Regulation and Diversifies Skin Microbiota – a Placebo-Controlled Double-Blinded Intervention Study
[Environment International] Investigators provided evidence in support of the core assumption of the hygiene and biodiversity hypotheses of immune-mediated diseases.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
