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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Microbiota-Driven Antitumour Immunity Mediated by Dendritic Cell Migration
[Nature] Scientists showed that a new strain of the bacterial genus Hominenteromicrobium isolated from the faeces of patients who responded to programmed cell death 1 blockade augmented antitumour responses in mice.
A Novel Immunocompetent Transgenic Mouse Model of DHF Reveals Syk-Mediated Th2-Polarized Cytokine Storm As a Key Driver of Vascular Leakage
[Emerging Microbes & Infections] Investigators established the first immunocompetent murine model of dengue hemorrhagic fever (DHF) with intact innate/adaptive immunity by generating hTim4-transgenic C57BL/6J mice.
OGG1 Augments the Transcriptional Activation of Foxp3 to Promote Itreg Differentiation for IBD Alleviation
[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified a function for OGG1 in regulating immune tolerance by promoting the differentiation of inducible regulatory T cells (iTreg).
Epigenetic Instability and Hypofunctionality of Fetal Tregs Allow a Permissive Regulatory Environment for T Effector Memory Maturation
[Proceedings of the National Academy of Sciences of the United States of America] Researchers examined the human fetal T cell immunome within the tissue and circulation environment using a mass cytometry approach, cross-referencing with their later age gradient database.
piENOX2 Regulates ALKBH5-Mediated Itga4 m6A Modification to Accelerate the Progression of Rheumatoid Arthritis
[Experimental & Molecular Medicine] Scientists observed elevated levels of macrophage-derived piENOX2 in the synovial tissues of both patients with rheumatoid arthritis and mice with collagen-induced arthritis.
Pentose Phosphate Pathway Inhibition Metabolically Reprograms CD8+ T Cells and Disrupts CNS Autoimmunity
[JCI Insight] Transcriptional profiling of central nervous system (CNS)-infiltrating CD8+ T cells in patients with multiple sclerosis indicated increased pentose phosphate pathway engagement, suggesting that this pathway is involved in CD8+ T cell-mediated injury of axons and neurons in the demyelinated CNS.
Targeted Degradation of sICOSL Reverses Cytotoxic T Cells Dysfunction
[Experimental Hematology & Oncology] Scientists found that increased soluble form of ICOSL (sICOSL) induced cytotoxic T cells dysfunction and was associated with shorter survival of patients with breast cancer.
Discovery of KBD4466, a Selective TLR 7/8 Inhibitor, for the Treatment of Autoimmune Diseases
[Journal of Medicinal Chemistry] Investigators discovered a small molecule inhibitor which demonstrates excellent cellular activity, favorable pharmacokinetic properties, potent inhibition of cytokine production in mouse pharmacodynamic studies, and outstanding therapeutic efficacy in an systemic lupus erythematosus animal model.
Bispecific Targeting of 4-1BB and CCR8 Boosts Antitumor Immunity Via Ti-Treg Depletion and CD8 Activation
[iScience] Researchers engineered a bispecific antibody, FRP303, targeting 4-1BB and CCR8, which are co-expressed on a highly immunosuppressive subset of tumor-infiltrating regulatory T cells.
Circulating T Regulatory Cells Are Persistently Reduced in Non-Severe Acquired Aplastic Anemia
[Current Medical Science] Investigators explored the frequency of circulating Tregs by multiparametric flow cytometry immunophenotyping in non-severe acquired aplastic anemia patients before and after immunosuppressive therapy.
Exploring UBASH3A: From Immune Regulation to Autoimmune Diseases
[Journal of Translational Medicine] The authors focus on the multifaceted regulatory roles of UBASH3A in biological processes within T cells.
Qu Biologics Completes Enrolment of a Unique Study Testing a Novel Immunomodulator to Restore Immune Function in the Elderly
[Qu Biologics, Inc.] Qu Biologics, Inc. reported that they have completed enrollment of all 72 participants in the RESILIENCE Study, an innovative randomized placebo-controlled Phase II clinical trial evaluating the ability of Qu’s first-in-class immunomodulator, QBKPN SSI, to restore innate immunity in people 65 years of age and older.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
