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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
The TRIB2-DNMT1 Pathway Generates an Immune Cold Microenvironment in Glioblastoma and Its Inhibition Promotes Immunotherapy
[Cancer Immunology Research] Investigators identified regulators of low CD8+ T-cell infiltration in glioblastoma (GBM). Using transcriptomic screening, they found that TRIB2 was a regulator of the immune-cold microenvironment characteristic of GBM.
An Oncolytic Vaccinia Virus Expressing Anti-CD47 Nanobody Exerts Enhanced Antitumor Activity by Mediating Innate and Adaptive Immune Cell Infiltration and Activation in the Lymphoma...
[Haematologica] Arming oncolytic vaccine virus with a CD47-blocking nanobody and IgG1 Fc created a dual-functional therapeutic platform, offering a paradigm-shifting strategy for lymphoma immunotherapy through coordinated innate and adaptive immune activation.
H3K27M Diffuse Midline Glioma Is Homologous Recombination Defective and Sensitized to Radiotherapy and NK Cell-Mediated Antitumor Immunity by PARP Inhibition
[Neuro-Oncology] Homologous recombination repair deficiency in histone H3 lysine 27-to-methionine diffuse midline glioma (H3K27M DMG) can be therapeutically leveraged with PARP inhibitors to radiosensitize and induce an NK cell-mediated antitumor immune response selectively in H3K27M DMG, supporting the clinical investigation of PARP1 inhibitors with radiotherapy in DMG patients.
Ad-SGE-DKK3 Gene Therapy Overcomes Resistance to Immune Checkpoint Blockade in Pleural Mesothelioma
[Clinical Cancer Research] Researchers performed preclinical studies to elucidate Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3)’s role in immune checkpoint inhibitors-resistant mouse mesothelioma.
IL-12-Producing Cytokine Factories Induce Precursor Exhausted T Cells and Elimination of Primary and Metastatic Tumors
[Journal for ImmunoTherapy of Cancer] Researchers evaluated the safety and antitumor efficacy of locally administered interleukin 12 (IL-12) using a clinically translatable cytokine delivery platform to identify Tpex recruitment capabilities at tolerable cytokine doses.
Targeted Release of a Bispecific Fusion Protein SIRPα/Siglec-10 by Oncolytic Adenovirus Reinvigorates Tumor-Associated Macrophages to Improve Therapeutic Outcomes in Solid Tumors
[Journal for ImmunoTherapy of Cancer] To identify the characteristics of recombinant adenovirus-SIRPα/Siglec-10, investigators conducted CCK8 assay, quantitative PCR, western blot, competitive binding assay, in vitro cytotoxicity assay, ELISA and phagocytosis assay.
Memory-Like Natural Killer Cell and CD19-Antibody Based Immunotherapy in Combination with Tyrosine-Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia
[Cancer Immunology Research] Investigators explored the potential of memory-like natural killer cells and Fc-enhanced CD19-ADCC in combination with tyrosine kinase inhibitor directed against kinase-driven leukemia models, including patient-derived xenografted Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL).
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type Ⅰ Interferon Signaling in Monocytes
[Cancer Immunology Research] Investigators synthetized mRNA encoding gasdermin E (GSDME) encapsulated by lipid nanoparticles (LNP-Gsdme). In situ delivery of LNP-Gsdme through intratumoral injection suppressed tumor growth, boosted monocyte infiltration and activated CD8+T cells.
Cxcr3 Promotes Protection from Colorectal Cancer Liver Metastasis by Driving NK Cell Infiltration and Plasticity
[Journal of Clinical Investigation] Researchers investigated the cellular and molecular factors required to facilitate the generation of an ILC1-like CD49a+NK cell population within the liver metastasis environment of colorectal cancer.
Lactate Activates Trained Immunity by Fueling the Tricarboxylic Acid Cycle and Regulating Histone Lactylation
[Nature Communications] Investigators demonstrated that trained monocytes preferentially employed lactate over glucose as a tricarboxylic acid cycle substrate, and lactate metabolism was required for trained immune cell responses to bacterial and fungal infection.
IMFINZI® (Durvalumab) Approved in the US As First and Only Perioperative Immunotherapy for Patients with Muscle-Invasive Bladder Cancer
[Astrazeneca] AstraZeneca’s Imfinzi in combination with gemcitabine and cisplatin as neoadjuvant treatment, followed by Imfinzi as adjuvant monotherapy after radical cystectomy has been approved in the US for the treatment of adult patients with muscle-invasive bladder cancer.
Tumor Cell Heterogeneity Drives Spatial Organization of the Intratumoral Immune Response
[Journal of Experimental Medicine] The authors modeled heterogeneous tumors comprised of “hot” and “cold” tumor populations, giving rise to T cell–rich and T cell–poor tumors, respectively, and introduced fluorescent labels to enable precise spatial tracking.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
