Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Induction of LY6E Regulates Interleukin-1β Production, Potentially Contributing to the Immunopathogenesis of Systemic Lupus Erythematosus
[Cell Communication and Signaling] By studying mouse bone marrow-derived macrophages, researchers showed that LY6E regulated IFN-α- and IC-induced production and secretion of mature interleukin-1β, foam cell formation, and several mitochondria-associated mechanisms.
T-Bet+ CXCR3+ B Cells Drive Hyperreactive B-T Cell Interactions in Multiple Sclerosis
[Cell Reports Medicine] Scientists showed that pro-inflammatory B-T cell-enriched cell clusters form during autoproliferation and mirror features of a germinal center reaction.
Early Notch Signals from Fibroblastic Reticular Cells Program Effector CD8+ T Cell Differentiation
[Journal of Experimental Medicine] Using genetic mouse models and blocking antibodies, scientists uncovered cellular and molecular mechanisms by which Notch signaling favored the efficient generation of effector CD8+ T cells.
Regulatory T Cells in the Mouse Hypothalamus Control Immune Activation and Ameliorate Metabolic Impairments in High-Calorie Environments
[Nature Communications] Investigators identified regulatory T cells (Tregs) as key modulators of hypothalamic immune responses. In mice, calorie-rich environments activated hypothalamic CD4+ T cells, infiltrating macrophages and microglia while reducing hypothalamic Tregs.
AGO2 Mediates Immunotherapy Failure via Suppressing Tumor IFN-Gamma Response-Dependent CD8+ T Cell Immunity
[Cell Reports] The authors showed that Argonaute 2 (AGO2), a key mediator in small RNA-guided gene regulation, inversely correlated with tumor responsiveness to interferon-gamma and the efficacy of immunotherapy.
Pharming Group Announces First Patient Dosed in Phase II Clinical Trial of Leniolisib for Common Variable Immunodeficiency (CVID) with Immune Dysregulation
[Pharming Group ] Pharming Group N.V. announced that the first patient has been dosed in a Phase II, proof of concept, clinical trial evaluating leniolisib in common variable immunodeficiency patients with immune dysregulation.
Systemic Lupus Erythematosus: Updated Insights on the Pathogenesis, Diagnosis, Prevention, and Therapeutics
[Signal Transduction and Targeted Therapy] Scientists propose three mechanisms with determinant roles on systemic lupus erythematosus initiation and progression: attenuating the immune system, restoring the cytokine microenvironment homeostasis, and rescuing the impaired debris clearance machinery
Immune Regulation by the SUMO Family
[Nature Reviews Immunology] The authors consider how studies provide scientific basis for future exploration of SUMO-mediated immune modulation for the treatment of cancers and autoimmune disorders.
Ligand-Induced Ubiquitination Unleashes LAG3 Immune Checkpoint Function by Hindering Membrane Sequestration of Signaling Motifs
[Cell] Lymphocyte activation gene 3 (LAG3) was found to undergo robust non-K48-linked polyubiquitination upon ligand engagement, which promoted LAG3’s inhibitory function instead of causing degradation.
QRICH1 Mediates an Intracellular Checkpoint for CD8+ T Cell Activation Via the CARD11 Signalosome
[Science Immunology] Researchers defined a role for glutamine-rich protein 1 (QRICH1) in T cell receptor signal transduction through regulation of the caspase recruitment domain–containing protein 11 signaling scaffold.
Activating Antiviral Immune Responses Potentiates Immune Checkpoint Inhibition in Glioblastoma Models
[Journal of Clinical Investigation] The authors found that targeting zinc finger protein 638 induced viral mimicry in glioblastoma preclinical models and potentiated immune checkpoint inhibition.
Chemoresistance and Immune Evasion in HCC: The Role of miRNA-425-5p
[Carcinogenesis] Scientists investigated the role of miRNA-425-5p in exosomes in modulating the tumor microenvironment (TME) and contributing to chemoresistance and immune evasion in HCC.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
