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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
IL-12-Producing Cytokine Factories Induce Precursor Exhausted T Cells and Elimination of Primary and Metastatic Tumors
[Journal for ImmunoTherapy of Cancer] Researchers evaluated the safety and antitumor efficacy of locally administered interleukin 12 (IL-12) using a clinically translatable cytokine delivery platform to identify Tpex recruitment capabilities at tolerable cytokine doses.
Targeted Release of a Bispecific Fusion Protein SIRPα/Siglec-10 by Oncolytic Adenovirus Reinvigorates Tumor-Associated Macrophages to Improve Therapeutic Outcomes in Solid Tumors
[Journal for ImmunoTherapy of Cancer] To identify the characteristics of recombinant adenovirus-SIRPα/Siglec-10, investigators conducted CCK8 assay, quantitative PCR, western blot, competitive binding assay, in vitro cytotoxicity assay, ELISA and phagocytosis assay.
Memory-Like Natural Killer Cell and CD19-Antibody Based Immunotherapy in Combination with Tyrosine-Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia
[Cancer Immunology Research] Investigators explored the potential of memory-like natural killer cells and Fc-enhanced CD19-ADCC in combination with tyrosine kinase inhibitor directed against kinase-driven leukemia models, including patient-derived xenografted Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL).
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type Ⅰ Interferon Signaling in Monocytes
[Cancer Immunology Research] Investigators synthetized mRNA encoding gasdermin E (GSDME) encapsulated by lipid nanoparticles (LNP-Gsdme). In situ delivery of LNP-Gsdme through intratumoral injection suppressed tumor growth, boosted monocyte infiltration and activated CD8+T cells.
Cxcr3 Promotes Protection from Colorectal Cancer Liver Metastasis by Driving NK Cell Infiltration and Plasticity
[Journal of Clinical Investigation] Researchers investigated the cellular and molecular factors required to facilitate the generation of an ILC1-like CD49a+NK cell population within the liver metastasis environment of colorectal cancer.
Lactate Activates Trained Immunity by Fueling the Tricarboxylic Acid Cycle and Regulating Histone Lactylation
[Nature Communications] Investigators demonstrated that trained monocytes preferentially employed lactate over glucose as a tricarboxylic acid cycle substrate, and lactate metabolism was required for trained immune cell responses to bacterial and fungal infection.
IMFINZI® (Durvalumab) Approved in the US As First and Only Perioperative Immunotherapy for Patients with Muscle-Invasive Bladder Cancer
[Astrazeneca] AstraZeneca’s Imfinzi in combination with gemcitabine and cisplatin as neoadjuvant treatment, followed by Imfinzi as adjuvant monotherapy after radical cystectomy has been approved in the US for the treatment of adult patients with muscle-invasive bladder cancer.
Tumor Cell Heterogeneity Drives Spatial Organization of the Intratumoral Immune Response
[Journal of Experimental Medicine] The authors modeled heterogeneous tumors comprised of “hot” and “cold” tumor populations, giving rise to T cell–rich and T cell–poor tumors, respectively, and introduced fluorescent labels to enable precise spatial tracking.
ACAT1 Regulates Tertiary Lymphoid Structures and Correlates with Immunotherapy Response in Non-Small Cell Lung Cancer
[Journal of Clinical Investigation] To identify such metabolic regulators, scientists constructed a metabolism-focused sgRNA library and performed an in vivo CRISPR screening in an orthotopic lung tumor mouse model.
Systemic Rewiring of Dendritic Cells by Melanoma-Secreted Midkine Impairs Immune Surveillance and Response to Immune Checkpoint Blockade
[Nature Cancer] Using cellular systems, mouse models and large datasets, the authors identified the tumor-secreted growth factor midkine as a multilayered inhibitor of antigen-presenting cells.
Ferroptosis: CD8+T Cells’ Blade to Destroy Tumor Cells or Poison for Self-Destruction
[Cell Death Discovery] The authors systematically elucidate the dual-edged sword role of ferroptosis in the antitumor process of T cells, briefly outlining the complexity of ferroptosis within the TME.
Genome-Wide CRISPR Screen in Human T Cells Reveals Regulators of FOXP3
[Nature] Researchers performed a genome-wide CRISPR loss-of-function screen to catalog gene regulatory determinants of FOXP3 induction in primary human T cells and characterized their effects at single-cell resolution using Perturb-icCITE-seq.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
