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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Allogeneic CD19-Targeting T Cells for Treatment-Refractory Systemic Lupus Erythematosus: A Phase 1 Trial
[Nature Medicine] Scientists developed YTS109, a hypoimmune allogeneic T cell product engineered using CRISPR–Cas9 to knock out TRAC, PD1, HLA-A, HLA-B, and CIITA, with a CD19-targeting synthetic TCR and antigen receptor (STAR) precisely integrated into the TRAC locus to enable physiological, TCR-like signaling.
CD371-Targeted CAR T Cells Secreting Interleukin-18 Exhibit Robust Expansion and Clear Refractory Acute Myeloid Leukemia
[Blood] Researchers developed CAR T-cells targeting CD371 with a mutated CD28 costimulatory domain to limit T cell exhaustion, and constitutive interleukin-18 secretion to enhance immune function.
CD99-Mediated Immunological Synapse Formation Potentiates CAR-T Cell Function
[Nature Communications] Investigators hypothesized that modifying the CAR structure to enhance immunological synapse (IS) stabilization and CAR target-binding may be a feasible strategy. They showed that the membrane protein, CD99, is critical for IS formation in T cells by mediating actin-microtubule interaction.
METTL14 Enhances Anti-Tumor Immunity through M6a-Dependent Loss of PD-1
[Cancer Research] Scientists demonstrated that the programmed cell death-1 (PD-1) gene PDCD1 undergoes m6A modification, which subsequently impacts T cell function. METTL14 mediated PDCD1 downregulation in T cells by promoting m6A-dependent destabilization of PDCD1 mRNA, a process mediated by YTHDF1/2/3.
Loss of YTHDF2 Enhances Th9 Programming and CAR-Th9 Cell Antitumor Efficacy
[Nature Immunology] Researchers showed that YTHDF2, an important m6A reader protein known to destabilize m6A-modified mRNA, negatively regulates Th9 cell differentiation.
Discovery of ETI41 and ETI60: Novel Selective Endosomal Toll-Like Receptor Inhibitors for the Treatment of Autoimmune Diseases
[Experimental & Molecular Medicine] ETI41 and ETI60 hold significant potential as therapeutic agents for the treatment of autoimmune and inflammatory diseases through selective targeting of endosomal Toll-like receptors.
A Bispecific Antibody-Drug Conjugate Targeting CD7 and CD33 Shows Anti-Tumor Activity and Improved Tumor Selectivity in an Aggressive Subtype of Acute Myeloid Leukemia
[mAbs] Scientists supported BVX001 as a new and promising approach for the treatment of acute myeloid leukemia (AML) CD33+CD7+ AML subtype, currently lacking targeted therapeutic options.
Pre-TCR-Targeted Immunotherapy for T Cell Acute Lymphoblastic Leukemia
[Nature Immunology] Investigators identified the pre-T cell receptor, a surface receptor essential for T cell development, as a biomarker of leukemia-initiating cells in human T cell acute lymphoblastic leukemia.
AEBP1 Drives Fibroblast-Mediated T Cell Dysfunction in Tumors
[Nature Communications] Researchers showed, by RNA-sequencing analysis of human colon adenocarcinoma and triple-negative breast cancer tissues, that expression of Adipocyte Enhancer-Binding Protein 1 (AEBP1) positively correlates with T cell dysfunction and is indicative of unfavorable patient outcomes.
Tumor-Derived EBI3 Promotes CD8+ T Cell Exhaustion via STAT4-IL-10/CCL5 in Gastric Cancer
[Cancer Immunology Research] Investigators reported the potential role of EBI3 in promoting T cell exhaustion and its mechanism in gastric cancer (GC), showing high expression of EBI3 in GC.
Th17 Cell Pathogenicity in Autoimmune Disease
[Experimental & Molecular Medicine] The authors discuss the pathogenic roles of Th17 cells in autoimmune diseases such as multiple sclerosis, inflammatory bowel disease and psoriasis, with emphasis on the cytokines, transcriptional regulators and metabolites that influence Th17 cell differentiation and pathogenicity.
Tissue-Resident T Cells That Promote Humoral Immunity: Emerging from the Shadow of T Follicular Helper Cells
[Immunological Reviews] Scientists summarize current knowledge of these tissue T-B helper cells, focusing on their differentiation and function in infection, cancer, and autoimmunity.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
