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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Altered T Cell Reactivity in the Early Stages of Alzheimer’S Disease
[Brain] Researchers employed high-dimensional mass cytometry, single-cell RNA-sequencing, ex vivo T cell secretome analysis, and antigen presentation assays to achieve a comprehensive characterization of adaptive immune cell populations.
Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
[Cancer Research] Scientists showed that delivery of only four synthetic guide RNAs with Cas9 endonuclease efficiently induced simultaneous DNA double-strand breaks, resulting in efficient cell death in a cell-type-specific manner.
Harm-Benefit Balance of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer
[JAMA Oncology] Investigators suggested that given both treatment-related harms and benefits, immune checkpoint inhibitor (ICI) + chemotherapy use in the first SACT setting requires informed decision-making; the potential benefits of ICI + chemotherapy vs single ICI in high-risk subgroups is encouraging.
Identification of the Distinct Immune Microenvironment Features Associated with Progression following High Dose Melphalan and Autologous Stem Cell Transplant in Multiple Myeloma
[Cancer Immunology Research] The authors identified cell interactions that predicted progression including increased frequency of CD8+ exhausted T cells and stromal cells and decreased frequency of CD56bright NK cells and plasmacytoid dendritic cells.
Tumor-Derived Erythropoietin Acts As an Immunosuppressive Switch in Cancer Immunity
[Science] Using spontaneous preclinical models of hepatocellular carcinoma (HCC) with distinct immunotypes, scientists showed that the EPO/EPOR axis functions as an immunosuppressive switch in macrophages that maintains a T cell–deprived tumor microenvironment, thus posing a major barrier to effective antitumor immunity.
Intensive Lowering of LDL Cholesterol Levels with Evolocumab in Autoimmune or Inflammatory Diseases: An Analysis of the FOURIER Trial
[Circulation] FOURIER was a randomized trial of evolocumab versus placebo in 27 564 patients with stable atherosclerosis who were taking statins. This analysis focused on the effect of evolocumab in patients with or without an autoimmune or inflammatory disease, defined as any autoimmune or chronic inflammatory condition.
Deconvoluting TCR-Dependent and -Independent Activation Is Vital for Reliable Ag-Specific CD4+ T Cell Characterization by AIM Assay
[Science Advances] Researchers showed that CD39+ regulatory T cell (Treg)–like and CD26hi TH22–like cells undergo T cell receptor–independent activation by cytokines during antigen stimulation, leading to nonspecific up-regulation of activation-induced marker readouts.
Repurposing Anti-Viral Subunit and mRNA Vaccines T Cell Immunity for Intratumoral Immunotherapy against Solid Tumors
[NPJ Vaccines] Scientists demonstrated the potential of licensed vaccines as promising platforms for intratumoral immunotherapy, either alone or combined with vaccine- or tumor-derived MHC-I-restricted peptide epitopes.
MARC, a Novel Modular Chimeric Antigen Receptor, Improves T Cell-Based Cancer Immunotherapies by Preventing Early T Cell Exhaustion, and Enhancing Persistence
[Journal of Immunotherapy of Cancer] Investigators developed a modular chimeric antigen receptor leveraging the same assembly principles found in native activating immune receptors to reestablish the intrinsic safeguards in receptor expression and signaling.
Follicular helper- and Peripheral Helper-Like T Cells Drive Autoimmune Disease in Human Immune System Mice
[eLife] Investigators demonstrated that PD-1+CD4+ peripheral helper-like and follicular helper-like T cells developing in human immune system mice could induce autoimmune disease.
A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD
[Journal of Clinical Immunology] Scientists described the immunological phenotype of one of the first reported cases of germline dominant negative HELIOS deficiency, expands our understanding of the pathogenesis of AIHA on a single cell level, and provides valuable insights into HELIOS function in a variety of lymphocyte subsets.
Efficacy of MET-Targeting CAR T Cells against Glioblastoma Patient-Derived Xenograft Models
[Journal of Translational Medicine] Whereas MET inhibitors are effective in MET-active tumors, MET-CAR T cells eradicate MET-positive glioblastoma (GBM) growth in an antigen-dependent manner, demonstrating a promising therapeutic approach for treating MET-positive GBM.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
