Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

MHC Class I on Target Cells Regulates CD4+ T Cell-Mediated Immunity

March 24, 2026

[Nature Immunology] Scientists suggested a role for CD4+ T cells in enhancing immune checkpoint blocker-mediated responses in people with melanoma and mismatch-repair-deficient colon cancers that have downregulated MHC class I.

Disruption of Metabolic Licensing by JAK Inhibitors Constrains CD8 T Cell Activation and Effector Function

March 24, 2026

[Cell Death & Disease] Researchers investigated naive and memory CD8 T cells from healthy donors stimulated in vitro in the presence of clinically relevant JAK inhibitors targeting JAK1, JAK1/2, or JAK1/3.

Glycosylation As a Dynamic Regulator of RLR and cGAS-STING Innate Immune Signaling Pathways

March 24, 2026

[Communications Biology] Scientists discuss crosstalk between glycosylation, ubiquitination, and phosphorylation, metabolic regulation of uridine diphosphate-N-acetylglucosamine flux, and pathogen- or tumor-driven glycosylation reprogramming, highlighting glycosylation enzymes as potential immunomodulatory targets.

Global Study from Feinstein Institutes to Unlock Secrets of Lupus Remission

March 23, 2026

[Feinstein Institutes for Medical Research] Scientists at Northwell Health’s Feinstein Institutes for Medical Research are launching a first-of-its-kind global clinical study to explore what is happening in the body and brain of lupus patients who appear to be in long-term remission and not taking strong medications.

Trinity Biotech Announces Collaboration with University at Buffalo to Commercialize Novel Biomarkers for Sjögren’s Syndrome

March 23, 2026

[Trinity Biotech] Trinity Biotech announced it has entered into a collaboration agreement with the University at Buffalo, New York. The partnership focuses on advancing and commercializing a suite of proprietary biomarkers for the earlier and more accurate detection of Sjögren’s Syndrome, a common but underdiagnosed autoimmune disease.

Cancer Research Innovator Joins UH to Develop Immunotherapies for Lung Cancer

March 23, 2026

[University of Houston] Dr. Akash Gupta will join the University of Houston Cullen College of Engineering as assistant professor and Presidential Frontier Faculty Fellow. Dr. Gupta will establish an independent research program to develop new platforms for cancer immunotherapies, initially focusing on lung cancer.

CXCR5+ Monocyte Emigration Impairs the Radiation-Induced Antitumor Immune Response

March 23, 2026

[Nature Communications] Scientists observed CXCR5+ monocytes are enriched in tumor upon radiation. Local radiation enhances CXCL13 expression from tumor cells, a specific ligand of CXCR5, which leads to the recruitment of CXCR5+ monocytes.

Dynamic Changes of the Immune Microenvironment in Ovarian Cancer following Neoadjuvant Chemotherapy

March 23, 2026

[Cell Death Discovery] Researchers analyzed published single-cell RNA sequencing data from patients with high-grade serous ovarian cancer and performed several in vitro and in vivo experiments to investigate the role of prostaglandins in immunosuppressive microenvironment formation.

Pediatric Bronchiolitis Disease Severity Is Associated with Immune Checkpoint Dysregulation

March 18, 2026

[Pediatric Research] The authors investigated the role of immune checkpoint molecules and regulatory cytokines in relation to disease severity.

Spatial Cartography of Human Thymus Enables the Geopositioning of Lineage Transcription Factors in Rare Mimetic Thymic Epithelial Cells

March 18, 2026

[Nature Communications] Researchers established a high-resolution spatial atlas of the human fetal and pediatric thymi to uncover distinct architectural features and transcription factors regulating these rare cell types.

Hyaluronic Acid-CD44 Signaling Defines Therapeutic Resistance and Immunosuppressive Microenvironment in Peritoneal Metastasis of Gastric Cancer

March 13, 2026

[Journal for Immunotherapy of Cancer] In both patient-derived samples and mouse models, CD44 blockade reduces Treg abundance, restores cytotoxic T cell activity, and enhances the therapeutic response to anti-PD-1 treatment.

Clinical Development of Cancer Vaccines

March 13, 2026

[Nature Medicine] The authors highlight insights from recent clinical trials, translational studies and preclinical models, which reveal critical factors for optimizing cancer vaccines.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.