Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Type I Interferon Autoantibody Footprints Reveal Neutralizing Mechanisms and Allow Inhibitory Decoy Design

March 20, 2025

[Journal of Experimental Medicine] With footprint profiling, scientists delineated two dominant IFN-I faces commonly recognized by neutralizing IFN-I autoantibody–containing plasmas from aged individuals with HIV-1 and from individuals with severe COVID-19.

Dominant Interfering CARD11 Variants Disrupt JNK Signaling to Promote GATA3 Expression in T Cells

March 20, 2025

[Journal of Experimental Medicine] Investigators showed that CARD11 was critical for TCR-induced activation of JNK1 and JNK2, as well as canonical JUN/FOS AP-1 family members.

Neoadjuvant Immune Checkpoint Therapy: Enabling Insights into Fundamental Human Immunology and Clinical Benefit

March 20, 2025

[Cancer Cell] The authors highlight recent clinical success of immune checkpoint therapy in the neoadjuvant setting, where treatment is given in earlier disease stages to improve outcomes and explore how neoadjuvant clinical trials could be utilized to drive mechanistic laboratory-based investigations.

Immune-Featured Stromal Niches Associate with Response to Neoadjuvant Immunotherapy in Oral Squamous Cell Carcinoma

March 20, 2025

[Cell Reports Medicine] Researchers used single-cell sequencing and spatial transcriptomics on paired tumor specimens from 22 patients with oral squamous cell carcinoma enrolled in a randomized two-arm Phase II trial.

Targeting Tumor-Intrinsic S100 Calcium-Binding Protein A1 Augments Antitumor Immunity and Potentiates Immunotherapy Efficacy

March 19, 2025

[Signal Transduction and Targeted Therapy] Investigators uncovered the potential of plasma S100 calcium-binding protein A1 (S100A1) for determining immune checkpoint blockade efficacy via liquid biopsy of patients with lung cancer.

Activated αβ T- and Reduced Mucosa-Associated Invariant T Cells in LGI1- and CASPR2-Encephalitis

March 18, 2025

[Brain] Researchers performed single cell RNA-sequencing of fresh cerebrospinal fluid and parallel blood samples of 15 patients with leucine-rich glioma inactivated-1 (LGI1)- and contactin-associated-protein-2 (CASPR2)-autoimmune encephalitis compared to control patients.

Epigenetic Therapy Sensitizes Anti-PD-1 Refractory Head and Neck Cancers to Immunotherapy Rechallenge

March 18, 2025

[Journal of Clinical Investigation] In a nonrandomized, open-label Phase 1b clinical trial, participants with recurrent and/or metastatic head and neck squamous cell carcinoma were treated with low-dose 5-azacytidine daily for either five or ten days in combination with durvalumab and tremelimumab after progression on immune checkpoint blockade.

Deep Immunophenotyping Reveals Circulating Activated Lymphocytes in Individuals at Risk for Rheumatoid Arthritis

March 18, 2025

[Journal of Clinical Investigation] The authors applied multimodal single-cell technologies to characterize the immunophenotypes in blood from at-risk individuals identified through the presence of serum antibodies against citrullinated protein antigens and/or first-degree relative status.

LJI Scientists Receive Curebound Funding to Advance Cancer Research

March 18, 2025

[3D Printing and Additive Manufacturing] Scientists at La Jolla Institute for Immunology (LJI) are advancing new cancer research programs, thanks to more than $1.7 million in funding from Curebound. These new grants will support innovative cancer studies in four LJI laboratories.

Ruxolitinib Combined with Dexamethasone for Adult Patients with Newly Diagnosed Hemophagocytic Lymphohistiocytosis in China

March 17, 2025

[Blood] In this prospective Phase II clinical trial, scientists proposed the ruxolitinib and dexamethasone regimen as a first-line treatment for adults newly diagnosed with hemophagocytic lymphohistiocytosis with unknown triggers.

Distinct CD8+ T Cell Dynamics Associate with Response to Neoadjuvant Cancer Immunotherapies

March 17, 2025

[Cancer Cell] To address whether successful immune checkpoint inhibitor regimens acted through similar or distinct pathways, investigators robustly and longitudinally characterized transcriptional and proteomic dynamics of CD8+ tumor-infiltrating lymphocytes in a clonal manner.

Microbiota-Produced Immune Regulatory Bile Acid Metabolites Control Central Nervous System Autoimmunity

March 17, 2025

[Cell Reports Medicine] Researchers showed that bacteria releasing enzymes responsible for secondary bile acid metabolites production were under-represented in the gut of multiple sclerosis patients.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.