Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

MASH: The Nexus of Metabolism, Inflammation, and Fibrosis

September 19, 2025

[Journal of Clinical Investigation] The authors outline how coordinated disruptions in lipid metabolism and intercellular signaling drive metabolic dysfunction–associated steatohepatitis (MASH) pathogenesis and provides a framework for understanding disease progression across tissue and cellular compartments.

KYLO-0603, a Novel Liver-Targeting, Thyroid Hormone receptor-β Agonist for the Inhibition of MASH Progression

September 19, 2025

[PLOS One] Investigators developed Kylo-0603, a novel agonist for the thyroid hormone receptor β, by merging the structures of three acetylgalactosamine-modified ASPGR ligands with a triiodothyronine analog.

Loss of Bile Salt Export Pump (Bsep/Abcb11) Ameliorates Toxin-Induced Hepatic Fibrosis via Suppression of Hepatocellular JNK Signaling and HSC Activation

September 19, 2025

[Cellular and Molecular Gastroenterology and Hepatology] Researchers investigated whether loss of Bsep may protect mice from development of toxin-induced liver fibrosis by directly impacting on hepatic stellate cell activation.

Targeting GCS Regulates the NRF2 Axis to Inhibit Hepatocyte Endoplasmic Reticulum Stress-Ferroptosis Improving Immune-Mediated Liver Injury

September 19, 2025

[International Immunopharmacology] Scientists used the GCS inhibitor GENZ-123346 (GENZ) to treat ConA-induced immune liver injury in mice. Inflammatory factor levels and liver histology were analyzed to evaluate GENZ's effects.

Reprogramming Cysteine Metabolism via METTL14-SLC7A11 Axis Promotes the Progression of NAFLD and Hepatocellular Carcinoma

September 19, 2025

[Life Sciences] The authors elucidated the role of METTL14 in cysteine metabolism and the progression of non-alcoholic fatty liver disease (NAFLD) and HCC in vivo by examining the amino acid metabolic profile of NAFLD-affected livers using a hepatocyte-specific METTL14 knockout mouse model.

Ether-Lipids Accumulation Promotes Hepatocellular Carcinoma Progression Linked to PPARα Deficiency

September 19, 2025

[Journal of Biomedical Science] Ninety-eight HCC patients were recruited between 2011 and 2013. Their specimens were subjected to transcriptomic and lipidomic profiling.

Crosstalk via ICAM-1 Enhances Supportive Phenotype of Stellate Cells and Drives Hepatocyte Proliferation in iPSC-Derived Hepatic Organoids

September 19, 2025

[Stem Cell Reports] Scientists established a novel contact co-culture organoids using iPSC-derived hepatic stellate-like cells and hepatocyte-like cells, termed iPSC-derived hepatocyte-stellate cell surrounding organoids.

Redox-Dependent Liver Gluconeogenesis Impacts Different Intensity Exercise in Mice

September 19, 2025

[Nature Metabolism] Investigators showed that preferential supplies of lactate and glycerol modulate hepatic gluconeogenesis, thereby impacting high-intensity and low-intensity exercise capacities, respectively.

Yale School of Medicine’s Dr. Gerald I. Shulman Named 2025 Recipient of American Liver Foundation’s Distinguished Scientific Achievement Award

September 19, 2025

[American Liver Foundation] American Liver Foundation announced that Dr. Gerald I. Shulman is the recipient of its 2025 Distinguished Scientific Achievement Award. Dr. Shulman is the George R. Cowgill Professor of Medicine and Cellular & Molecular Physiology at Yale School of Medicine, and Co-Director of the Yale Diabetes Research Center.

Lycopene Inhibits Zearalenone-Induced Ferroptosis via Activating AMPK/Nrf2 Signaling Pathway in AML-12 Hepatocytes and in Mice Livers

September 17, 2025

[Ecotoxicology and Environmental Safety] Researchers assessed lycopene's antiferroptotic effects and mechanisms using an mouse model and a cellular model stimulated with zearalenone.

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

September 11, 2025

[Advanced Science] To uncover tumor suppressors in human HCC, scientists performed a genome-wide CRISPR/Cas9-based screening of primary human hepatocytes with MYC and TP53^R249S overexpression is performed in xenografts.

Grant Awarded to Investigator-Initiated Phase II/III Trial with Mitazalimab in Biliary Tract Cancer

September 9, 2025

[Alligator Bioscience (BioSpace)] Alligator Bioscience announced that an investigator-initiated randomized Phase II/III clinical trial will evaluate mitazalimab in combination with FOLFOX chemotherapy in previously treated biliary tract cancer.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!