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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
TMEM101 Expression and Its Impact on Immune Cell Infiltration and Prognosis in Hepatocellular Carcinoma
[Scientific Reports] Scientists presented herein offer initial evidence indicating a significant upregulation of TMEM101 mRNA expression in hepatocellular carcinoma, which iwa linked to a poorer prognosis.
Sulfonated Albumin from Hepatocytes Accelerates Liver Fibrosis in Nonalcoholic Fatty Liver Disease Through Endoplasmic Reticulum Stress
[Free Radical Biology and Medicine] Researchers investigated the mechanism underlying sulfonated albumin production and its role in the progression of nonalcoholic fatty liver disease-related liver fibrosis.
Lactoferrin Targeting INTL1 Receptor Inhibits Hepatocellular Carcinoma Progression via Apoptosis and Cell Cycle Signaling Pathways
[Scientific Reports] Investigators focused on evaluating lactoferrin’s (LF) anti-liver cancer effects on hepatocellular carcinoma cells and assessing the preventive efficacy of oral LF administration in a murine model.
TRIM32 Regulates Insulin Sensitivity by Controlling Insulin Receptor Degradation in the Liver
[EMBO Reports] Scientists identified an E3 ubiquitin ligase, tripartite motif-containing protein 32 (TRIM32), as a key regulator of hepatic insulin signaling that targets the insulin receptor for ubiquitination and proteasomal degradation in high-fat diet mice.
Calpain 2 Promotes Lenvatinib Resistance and Cancer Stem Cell Traits via Both Proteolysis-Dependent and Independent Approach in Hepatocellular Carcinoma
[Molecular Biomedicine] Researchers employed integrated bioinformatic analysis to identify calpain-2 as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples.
FBP1 Controls Liver Cancer Evolution from Senescent MASH Hepatocytes
[Nature] While increasing HCC risk, metabolic-dysfunction-associated steatohepatitis (MASH) triggers p53-dependent hepatocyte senescence, which we found to parallel hypernutrition-induced DNA breaks.
Mangiferin Mitigates Methotrexate-Induced Liver Injury and Suppresses Hepatic Stellate Cells Activation in Rats: Imperative Role of Nrf2/NF-κB/NLRP3 Signaling Axis
[Journal of Ethnopharmacology] Investigators unravelled the hepatoprotective potential of mangiferin against MTX-induced hepatic injury and fibrosis and elucidated the possible underlying molecular mechanisms.
Lipidome Profiling in Advanced Metabolic Liver Disease Identifies Phosphatidylserine Synthase 1 as a Regulator of Hepatic Lipoprotein Metabolism
[Cell Reports] Researchers showed that phosphatidylserine (PS) accumulation and preservation of PS synthase 1 (PSS1) expression was associated with resistance to metabolic dysfunction-associated steatohepatitis and hypertriglyceridemia.
Utility of Mac-2 Binding Protein Glycosylation Isomer as an Excellent Biomarker for the Prediction of Liver Fibrosis, Activity, and Hepatocellular Carcinoma Onset: An Expert...
[Journal of Gastroenterology] The usefulness of M2BPGi for assessing disease progression in patients with various chronic liver diseases has been demonstrated over the past decade in a large number of patients.
Precision Models in Hepatocellular Carcinoma
[Nature Reviews Gastroenterology & Hepatology] The authors delve into the intricate world of HCC, describing the most innovative model systems that can be harnessed to identify precision and/or personalized therapies.
Efficacy and Safety of Lenvatinib plus Gefitinib in Lenvatinib-Resistant Hepatocellular Carcinomas: A Prospective, Single-Arm Exploratory Trial
[Signal Transduction and Targeted Therapy] Scientists present the results of a single-arm, open-label, exploratory study of lenvatinib plus the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib for patients with HCC resistance to lenvatinib.
Current and Emerging Strategies for the Prevention of Hepatocellular Carcinoma
[Nature Reviews Gastroenterology & Hepatology] A multifaceted approach that combines pharmacological, lifestyle and dietary strategies shows promise for tailored HCC prevention, but rigorous randomized trials are needed to validate clinical efficacy and safety.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
