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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
FDA Approves Treatment for Serious Liver Disease Known as ‘MASH’
[FDA] The US FDA has approved Wegovy injection to treat metabolic-associated steatohepatitis (MASH) in adults with moderate-to-advanced fibrosis.
ZEB1 Stratifies the Response to Sorafenib and Mdivi-1 Combination Therapy in Hepatocellular Carcinoma
[Scientific Reports] Researchers investigated the apoptotic potential of pharmacological inhibition of mitochondrial metabolism in primary liver cancer and whether this strategy can reduce ZEB1-associated resistance to standard of care chemotherapy Sorafenib.
ALKBH5 Deficiency Suppresses Hepatocarcinogenesis in Mice via m6a-Dependent STAT1 Restoration
[Acta Pharmacologica Sinica] The authors investigated the contribution of the m6A eraser AlkB homolog 5 (ALKBH5) to hepatocarcinogenesis, particularly during the early stages of liver cancer development.
Genetic Variants Underlying Precancerous Conditions of Hepatocellular Carcinoma
[International Journal of Cancer] Investigators summarize key genetic variants associated with precancerous conditions leading to HCC.
Dysregulation of GTPase-Activating Protein-Binding Protein1 in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease
[Nature Communications] Researchers found reduced levels of GTPase-activating protein-binding protein1 in patients with metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis, suggesting its involvement in these liver disorders.
Circadian Clocks and Periodic Anticipated Fasting Prevent Fasting-Associated Hepatic Steatosis in Calorie Restriction
[Cell Reports] Investigators compared caloric restriction (CR) with unanticipated fasting (F), when the food is unexpectedly withheld. F induces hepatic steatosis, whereas CR reduces it.
Role of CD133 Antibody-Conjugated Nanocarrier in Enhancing the Targetability of Hepatocellular Carcinoma Stem Cells
[Scientific Reports] Scientists aimed at targeting hepatic cancer stem cells with quercetin or kaempferol loaded into poly(lactide-co-glycolide) nanoparticles decorated with CD133 antibody.
NADPH Oxidase 1/4 Dual Inhibition Impairs Transforming Growth Factor-Beta Protumorigenic Effects in Cholangiocarcinoma Cancer-Associated Fibroblasts
[Signal Transduction and Targeted Therapy] Researchers showed that TGF-β signaling is highly active in intrahepatic cholangiocarcinoma (iCCA) and exerts a prominent suppressor effect on tumor cell lines and organoids established from iCCA metastases biopsies.
Exosomes from Liver Progenitor Cells Carrying JAG1 Activate Notch Signaling to Promote Liver Regeneration in PVL Rats
[Cell Death & Disease] Researchers demonstrated that exosomes from hypertrophic liver tissue can activate the YAP-Notch signaling pathway both in vitro and in vivo, thereby promoting liver regeneration after portal vein ligation.
MetaVia Announces AI-Driven Collaboration with Syntekabio to Explore Additional Indications for DA-1241
[MetaVia] MetaVia Inc. announced a research collaboration with Syntekabio, Inc. to identify additional disease targets and optimize the therapeutic profile of DA-1241, MetaVia's novel oral G-Protein-Coupled Receptor 119 agonist.
Regulatory Mechanisms of Hepatocyte PCSK9 Expression: Translating Mechanistic Insights into Potential Nutraceuticals
[Chinese Medicine] The authors explore the intricate regulatory network that controls hepatic proprotein convertase subtilisin/kexin type 9 (PCSK9) expression and explores how these molecular insights can be translated into nutraceutical applications.
Hepatocyte KCTD17-Mediated SERPINA3 Inhibition Determines Liver Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis
[Experimental & Molecular Medicine] Researchers identified increased KCTD17 levels in patients with metabolic dysfunction-associated steatohepatitis (MASH), and in dietary rodent models of MASH which showed an inverse correlation with the expression of serine protease inhibitor a3k.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
