Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Identification of Chikusetsusaponin IVa as a Novel Lysine-Specific Demethylase 1 Inhibitor That Ameliorates High Fat Diet-Induced MASLD in Mice
[Acta Pharmacologica Sinica] Researchers investigated the beneficial effects of chikusetsusaponin IVa (CHS) on metabolic dysfunction steatotic liver disease (MASLD) and the underlying mechanisms. MAFLD mouse model was established by the high-fat diet for 6 weeks and then were treated with CHS for another 8 weeks.
β-Catenin Disruption Decreases Macrophage Exosomal α-SNAP and Impedes Treg Differentiation in Acute Liver Injury
[JCI Insight] Scientists found that the hepatic Treg proportion and β-catenin expression in hepatic macrophages were associated with acetaminophen and D-galactosamine/ lipopolysaccharide-induced acute liver injury.
DSN1 Interaction with Centromere-Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma
[Molecular Carcinogenesis] Researchers utilized The Cancer Genome Atlas, the HCC Cell Database, and other databases to analyze dosage suppressor of NNF1 (DSN1) expression and prognosis in samples from patients with HCC.
SLC1A3 Is a Novel Prognostic Biomarker Associated with Immunity and EMT in Hepatocellular Carcinoma
[Discover Oncology] Investigators examined the levels of solute carrier family 1 member 3 (SLC1A3) within HCC and its implications on immunological and epithelial–mesenchymal transition features using the TCGA, ImmPort, and Molecular Signatures databases.
MIST1 Regulates Endoplasmic Reticulum Stress-Induced Hepatic Apoptosis as a Candidate Marker of Fatty Liver Disease Progression
Scientists investigated the dynamics of gene expression associated with the progression of liver disease. They analyzed changes in gene expression over time in a...
Hepatocellular Senescence Induces Multi-Organ Senescence and Dysfunction via TGFβ
[Nature Cell Biology] Investigators demonstrated senescence development in extrahepatic organs and associated organ dysfunction in response to liver senescence using liver injury models and genetic models of hepatocyte-specific senescence.
BAIAP2L2 Promotes the Malignancy of Hepatocellular Carcinoma via GABPB1-Mediated Reactive Oxygen Species Imbalance
[Cancer Gene Therapy] Researchers identified an upregulation of BAI1-associated protein 2-like 2 (BAIAP2L2) in HCC tissues, which was found to be an independent prognostic factor for overall survival in HCC patients.
PTPRK Regulates Glycolysis and De Novo Lipogenesis to Promote Hepatocyte Metabolic Reprogramming in Obesity
[Nature Communications] Scientists report that obesity led to dysregulated expression of hepatic protein-tyrosine phosphatases. PTPRK was found to be increased in steatotic hepatocytes in both humans and mice, and correlated positively with PPARγ-induced lipogenic signaling.
Early-Life Antibiotic Exposure Aggravate the Metabolic Dysfunction-Associated Steatotic Liver Disease Associated Hepatocellular Carcinoma
[BMC Cancer] Scientists investigated the role of early-life gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease-HCC in streptozotocin and high-fat diet induced mouse model.
Controlled Release of Hydrogel-Encapsulated Mesenchymal Stem Cells-Conditioned Medium Promotes Functional Liver Regeneration after Hepatectomy in Metabolic Dysfunction-Associated Steatotic Liver Disease
[Stem Cell Research & Therapy] Male Lewis rats were fed with a methionine and choline–deficient diet. After three weeks of feeding, partial hepatectomy was performed and rats were randomly allocated into two groups that received hydrogel-encapsulated mesenchymal stem cells-conditioned medium or vehicle via the intra-mesenteric space of the superior mesenteric vein.
Rab2A-Mediated Golgi-Lipid Droplet Interactions Support Very-Low-Density Lipoprotein Secretion in Hepatocytes
[EMBO Journal] The authors revealed the role of Ras-related protein Rab-2A (Rab2A) in mediating lipid droplet-Golgi interactions, thereby contributing to very-low-density lipoprotein lipidation and secretion in hepatocytes.
Downregulation of GLYAT Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma
[Journal of Cellular and Molecular Medicine] Glycine N-acyltransferase (GLYAT) expression levels in HCC tissues were significantly reduced compared to normal liver tissues.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
