Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Progress of Pyruvate Kinase M2 in Hepatocellular Carcinoma-Associated Signaling Pathway

March 20, 2025

[Tissue Engineering Part C-Methods] Investigators underscore PKM2’s role in HCC development, influencing both glycolytic metabolism and oncogenic signaling pathways like PI3K/AKT/mTOR and MAPK.

Precision BioSciences Announces Clearance of Investigational New Drug Application by the US FDA for First-in-Class PBGENE-HBV Designed to Eliminate Root Cause of Chronic Hepatitis...

March 20, 2025

[Precision BioSciences, Inc.] Precision BioSciences, Inc. announced that the US FDA has cleared the Investigational New Drug application for PBGENE-HBV. PBGENE-HBV is Precision’s lead wholly owned in vivo gene editing program designed to cure chronic hepatitis B by eliminating cccDNA

Oncolytic Virus VG161 in Refractory Hepatocellular Carcinoma

March 20, 2025

[Nature] Researchers presented the results of a multicentre Phase I clinical trial evaluating VG161 for safety and efficacy in patients with advanced liver cancer.

Pyruvate Metabolism Enzyme DLAT Promotes Tumorigenesis by Suppressing Leucine Catabolism

March 19, 2025

[Cell Metabolism] The authors revealed that dihydrolipoamide S-acetyltransferase (DLAT), a pyruvate metabolism enzyme, promoted leucine accumulation and sustained mammalian target of rapamycin complex activation in HCC.

TRIM21 Modulates Stability of Pro-Survival Non-Coding RNA vtRNA1-1 in Human Hepatocellular Carcinoma Cells

March 18, 2025

[PLOS Genetics] Scientists described a regulatory process for vtRNA1-1 stabilization mediated by the newly identified interacting proteins, TRIM21 and TRIM25, in human HCC cells.

Exploring the Combined Roles of GALNT1 and GALNT2 in Hepatocellular Carcinoma Malignancy and EGFR Modulation

March 18, 2025

[Discover Oncology] Researchers explored the combined effects of GALNT1 and GALNT2 transfection on HCC, compared to the effects of modifying each gene individually.

The Role of Mitochondrial Dysfunction in the Protective Effect of Ginger Derived Extracellular Vesicles on Hepatic Stellate Cells against Cytotoxicity

March 18, 2025

[Molecular and Cellular Biochemistry] The authors provided evidence that ginger-derived extracellular vesicles effectively interacted with human hepatic stellate cells, offering protection against carbon tetrachloride or lipopolysaccharides-induced liver fibrosis.

BAIAP2L2 Facilitates Hepatocellular Carcinoma Progression and Immune Evasion of via Targeting JAK1-Mediated Pathway and PD-L1 Expression

March 18, 2025

[Cancer Gene Therapy] Scientists investigated the impact of brain-specific angiogenesis inhibitor 1-associated protein 2-like 2 (BAIAP2L2) in HCC and elucidated its potential mechanisms in this context.

Exploring the Molecular Mechanisms through Which Overexpression of TET3 Alleviates Liver Fibrosis in Mice via Ferroptosis in Hepatic Stellate Cells

March 18, 2025

[Cellular Signalling] Investigators explored the molecular mechanisms wherein TET3 overexpression improved liver fibrosis in mice via ferroptosis in hepatic stellate cells.

Statin Use and Risk of Hepatocellular Carcinoma and Liver Fibrosis in Chronic Liver Disease

March 18, 2025

[JAMA Internal Medicine] This cohort study used data from the Research Patient Data Registry from 2000 to 2023 on patients 40 years or older with chronic liver disease and a baseline fibrosis-4 score of 1.3 or higher. Participants were grouped into statin users and nonusers.

HLA-DQB1*03:01 and Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma

March 17, 2025

[Hepatology] Scientists investigated associations of human leukocyte antigen (HLA) variants, amino acid polymorphisms, zygosity, and evolutionary divergence with hepatitis B virus-related HCC in Han Chinese and explored biological mechanisms.

Proteasomal Processing of the Viral Replicase ORF1 Facilitates HEV-Induced Liver Fibrosis

March 17, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Researchers found that the viral multiple-domain replicase (ORF1) underwent unique ubiquitin–proteasomal processing leading to formation of the HEV-Derived SMAD Activator, a viral polypeptide lacking putative helicase and RNA polymerase domains.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!