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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Synergistic Activity of Combined FLT3-ITD and MDM2 Inhibition With Quizartinib and Milademetan in FLT3-ITD Mutant/TP53 Wild Type Acute Myeloid Leukemias
[Clinical Cancer Research] The authors investigated the antileukemia efficacy of co-targeting FLT3 and MDM2 with quizartinib and milademetan in FLT3-internal tandem duplication AML cell lines, xenograft and patient-derived xenograft models, and a Phase I clinical trial.
Menin Inhibition with Revumenib for NPM1-Mutated Relapsed or Refractory Acute Myeloid Leukemia: The AUGMENT-101 Study
[Blood] Scientists presented results from patients with relapsed or refractory nucleophosmin 1-mutated AML enrolled in the Phase II portion of AUGMENT-101.
Novel, Potent, and Orally Bioavailable LSD1 Inhibitors Induce Fetal Hemoglobin Synthesis in a Sickle Cell Disease Mouse Model
[Blood] Investigators utilized structure-aided drug design to develop potent new reversible lysine-specific demethylase 1 (LSD1) inhibitors leading to robust γ-globin expression in vitro.
Improved Outcomes of Acute Lymphoblastic Leukemia after Allogeneic Blood or Marrow Transplantation with High-Dose Post-Transplantation Cyclophosphamide in the Era of More Effective Pre-Transplant Therapy
[Haematologica] Scientists analyzed the outcomes of 251 adult ALL atients undergoing allogeneic blood or marrow transplantation with post-transplantation cyclophosphamide across two eras: 2008-2014 and 2015-2022.
Advances in Host-Directed Therapy for Tuberculosis and HIV Coinfection: Enhancing Immune Responses
[Trends In Microbiology] Scientists explore key host-directed therapys, including cytokine therapy, CAR-T cell therapy and immune checkpoint inhibitors, which target Mycobacterium tuberculosis-infected cells, enhance immune responses, and mitigate inflammation.
Molecular Mechanisms of Viral Oncogenesis in Haematological Malignancies: Perspectives from Metabolic Reprogramming, Epigenetic Regulation, and Immune Microenvironment Remodeling
[Experimental Hematology & Oncology] The authors delve into the contributions of various known viruses—specifically Epstein-Barr virus, HIV, human T cell leukemia virus type 1, Kaposi’s sarcoma-associated herpesvirus, human cytomegalovirus, hepatitis B virus, hepatitis C virus, and human papillomavirus—in the development of haematological malignancies.
MicroRNA Changes with Macro Potential Contribute to Secondary Immunodeficiency in Chronic Lymphocytic Leukemia during Epstein Barr Virus Reactivation
[Scientific Reports] Researchers examined the interplay between miRNA expression profiles, Epstein-Barr virus reactivation, and immune checkpoint pathways in the context of small intestine disease development in chronic lymphocytic leukemia.
Suppression of the Prostaglandin I2–Type 1 Interferon Axis Induces Extramedullary Hematopoiesis to Promote Cardiac Repair after Myocardial Infarction
To assess the role of spleen extramedullary hematopoiesis (EMH) in myocardial infarction (MI), scientists constructed a Tcf21CreER Scfflox/flox MI mouse model with inhibited EMH.
[Circulation] Full...
Overexpressing Natural Killer Group 2 Member a Drives Natural Killer Cell Exhaustion in Relapsed Acute Myeloid Leukemia
[Signal Transduction and Targeted Therapy] Researchers investigated NK cell exhaustion in relapsed AML patients following allogeneic hematopoietic stem cell transplantation through phenotypic assessments, functional assays, and RNA sequencing analyses.
PIEZO1 Activation-Mediated Generation of Transgene-Free Long-Term Hematopoietic Stem Cells
[American Journal of Hematology] Investigators found that pulsation-mediated circumferential stretch was restricted to the ventral part of the dorsal aorta and activated Piezo1 to stimulate long-term reconstituting hematopoietic stem cells formation.
Outcomes of Allogeneic Haemopoietic Transplant for Chronic Lymphocytic Leukaemia in the Modern Era
[Internal Medicine Journal] Scientists examined the use of HSCT performed for chronic lymphocytic leukaemia in Australia and New Zealand, including patients exposed to pathway inhibitors prior to transplant.
Emerging Therapeutic Approaches for Anemia in Myelofibrosis
[Current Hematologic Malignancy Reports] The authors highlight conventional agents and novel emerging therapeutic strategies to treat anemia in myelofibrosis.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
