Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
A Genome-Wide Screen Identifies Runx2 As a Novel Regulator of Hematopoietic Stem Cell Expansion and T-Cell Commitment
[Blood] Scientists performed a genome-wide CRISPR knockout screen in primary mouse hematopoietic stem and progenitor cells to discover novel regulators of ex vivo expansion. The screen identified Runx2 as a strong negative regulator of HSC expansion.
CRISPR-Engineered Human GATA2 Deficiency Model Uncovers Mitotic Dysfunction and Premature Aging in HSPCs, Impairing Hematopoietic Fitness
[Leukemia] Researchers developed a novel humanized model using CRISPR/Cas9 technology to knock-in GATA2-R398W variant in primary cord blood CD34⁺ cells.
Somatic mtDNA Mutations at Intermediate Levels of Heteroplasmy Are a Source of Functional Heterogeneity among Primary Leukemic Cells
[Science Advances] Bulk whole-genome sequencing of 637 matched tumor-normal samples from the Pediatric Cancer Genome Project revealed an enrichment of functionally impactful mitochondrial DNA variants in specific pediatric leukemia subtypes.
The Mitochondrial Protease ClpP Is a Metabolic Vulnerability and an Immunogenic Trigger against Multiple Myeloma
[Blood] Researchers showed that the mitochondrial protease caseinolytic peptidase P (ClpP) is both a cell-intrinsic metabolic vulnerability and an actionable immunogenic trigger in multiple myeloma.
Transposable Elements As Novel Therapeutic Targets for PARPi-Induced Synthetic Lethality in PcG-Mutated Blood Cancer
[Blood] Investigators showed that genetic inactivation of additional sex combs like 1 and enhancer of zeste homolog 2 in murine hematopoietic stem/progenitor cells results in highly penetrant hematological malignancies as observed in corresponding human diseases.
Molecular Insights into the Pathophysiology of Dysregulated Erythropoiesis: The Crucial Role of Iron Homeostasis
[Molecular and Cellular Biology] The authors summarize the current understanding of the mechanisms by which iron imbalance contributes to erythropoietic failure and highlight BACH1 as a potential integrative regulator in the pathophysiology of anemia in both iron-overload and iron-deficient states.
DUX4-Rearranged B-ALL: Deciphering a Biological and Clinical Conundrum
[Leukemia] The authors explore the genetic and biological features of DUX4 and its rearrangements, shedding light on their role in leukemogenesis and associated clinical outcomes.
Tumors Hijack Macrophages for Iron Supply to Promote Bone Metastasis and Anemia
[Cell] The authors showed that a specialized population of VCAM1+CD163+CCR3+ macrophages, normally essential for erythropoiesis by transporting iron to erythroblasts, are highly enriched in the bone metastatic niche in mouse models.
CUX1 Restrains Latent Hematopoietic Stem Cell Plasticity by Suppressing Stem Cell-Intrinsic Inflammatory Pathways
[Blood] Using novel mouse models and single-cell approaches, researchers reported that dynamic and distinct CUX1 levels are integral to HSC activity.
Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging
[Blood] Scientists showed that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging.
Nanobioreactor Detection of Space-Associated Hematopoietic Stem and Progenitor Cell Aging
[Cell Stem Cell] Investigators developed bone marrow niche nanobioreactors with lentiviral bicistronic fluorescent, ubiquitination-based cell-cycle indicator reporter for real-time hematopoietic stem and progenitor cell tracking in artificial intelligence-driven CubeLabs.
Targeting O-GlcNAcylated METTL3 Impedes MDS/AML Progression via Diminishing SRSF1 m6a Modification
[Molecular Therapy] Researchers found that methyltransferase-like protein 3 (METTL3) is O-GlcNAcylated in both myelodysplastic syndrome and acute myeloid leukemia, and its expression positively correlates with O-GlcNAcylation levels.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
