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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Mis-Splicing-Derived Neoantigens and Cognate TCRs in Splicing Factor Mutant Leukemias
[Cell] Researchers utilized feature-barcoded peptide-major histocompatibility complex dextramers to isolate neoantigen-reactive T cell receptors from healthy donors, patients with active myeloid malignancy, and following curative allogeneic stem cell transplant
An Oncolytic Adenovirus Targeting SLAMF7 Demonstrates Anti-Myeloma Efficacy
[Leukemia] Researchers investigated a novel SLAMF7-promoter driven oncolytic adenovirus as a potential therapeutic for multiple myeloma, an incurable hematological malignancy.
Heterogeneity of High-Potency Multilineage Hematopoietic Stem Cells and Identification of ‘Super’ Transplantability
[Blood] Scientists conducted large-scale single-clone serial-transplant experiments and tracked descendant cells of 288 HSC clones to quantify their intrinsic capability for hematopoietic reconstitution.
Orchestration of Human Multi-Lineage Hematopoietic Cell Development by Humanized In Vivo Bone Marrow Models
[Hemasphere] Researchers thoroughly characterized a humanized in vivo bone marrow model, developed from fetal and post-natal mesenchymal stromal cell differentiation, in which human hematopoietic cells were generated following the transplantation of CD34+ cells.
Microbial Metabolite Drives Aging-Related Clonal Hematopoiesis via ALPK1
[Nature] Investigators showed that intestinal alterations, which can occur with age, led to systemic dissemination of a microbial metabolite that promoteed pre-leukemic cell expansion.
A Phase I / IIa Trial of PXS-5505, a Novel Pan-Lysyl Oxidase Inhibitor, in Advanced Myelofibrosis
[Haematologica] PXS5505-MF-101 was a multi-center Phase I/IIa study of PXS-5505 in myelofibrosis patients which included a dose escalation phase and a cohort expansion phase.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes: A Practical Guide to Diagnosis and Management
[Leukemia] Scientists provide a practical guide for the diagnosis and management of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes.
Outcomes and Treatment Patterns in Primary and Secondary Plasma Cell Leukemia: Insights from a Large US Cohort Study
[Haematologica] Investigators conducted a large retrospective analysis of 153 plasma cell leukemia patients, using the new definition of ≥ 5% circulating plasma cells, including clinical features and treatment outcomes across seven academic centers in United States.
Myelopoiesis Is Temporally Dynamic and Is Regulated by Lifestyle to Modify Multiple Sclerosis
[Nature Communications] In mice with relapsing-remitting experimental autoimmune encephalomyelitis, myelopoiesis in the femur, vertebrae, and spleen was elevated prior to disease onset and during remission, preceding the peaks of clinical disability and neuroinflammation.
Reduced Venetoclax Exposure to 7 Days Vs Standard Exposure with Hypomethylating Agents in Newly Diagnosed AML Patients
[Blood Cancer Journal] Scientists retrospectively compared newly diagnosed AML patients treated with azacitidine x seven days plus venetoclax (VEN) x seven days from the first cycle vs patients treated with standard dose hypomethylating agent + VEN.
Dasatinib and CAR T-Cell Therapy in Newly Diagnosed Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
[JAMA Oncology] In this Phase II, single-arm, nonrandomized clinical trial that included 28 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia, the complete molecular remission rate after CD19 chimeric antigen receptor (CAR) T cell therapy was 85%.
Metformin Reduces the Competitive Advantage of Dnmt3aR878H HSPCs
[Nature] Researchers showed that mouse hematopoietic stem and progenitor cells (HSPCs) carrying the Dnmt3aR878H/+ mutation had increased mitochondrial respiration compared with wild-type cells and were dependent on this metabolic reprogramming for their competitive advantage.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
