Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review

March 14, 2025

[American Journal of Hematology] The authors provide a contemporary review on HSC transplantation for myelodysplastic neoplasms and myelofibrosis, highlighting up-to-date insights into disease biology, standard of care, and recommendations, as well as open avenues.

KDM4B Modulates Autocrine IL6 in Erythroblasts to Prevent Ineffective Erythropoiesis

March 14, 2025

[Leukemia] Scientists found that the kdm4b−/− mutant zebrafish developed an ineffective erythropoiesis-like defect, including impaired terminal maturation and apoptosis of erythroblasts, as confirmed by observations in Kdm4b−/− mutant mice.

Impact of Treatment for Adolescent and Young Adults with Essential Thrombocythemia and Polycythemia Vera

March 14, 2025

[Leukemia] This retrospective study of essential thrombocythemia and polycythemia vera patients diagnosed before age 25 evaluated complication rates and impact of cytoreductive drugs on outcomes.

Leukemogenic Kras Mutation Reprograms Multipotent Progenitors to Facilitate Its Spread through the Hematopoietic System

March 13, 2025

[Journal of Experimental Medicine] The authors genetically induced mutations within endogenous murine HSC and traced them in unmanipulated animals. In contrast to mutations associated with clonal hematopoiesis, the leukemogenic KrasG12D mutation dramatically accelerated HSC contribution to all hematopoietic lineages.

Clonal Hematopoiesis Landscape in Frequent Blood Donors

March 13, 2025

[Blood] Functional analysis of frequent donor enriched DNMT3A variants examined in CRISPR-edited human HSCs demonstrated their competitive outgrowth potential upon stimulation with erythropoietin, a hormone which increases in response to blood loss.

Olverembatinib Granted Breakthrough Therapy Designation for the Treatment of Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)

March 11, 2025

[Ascentage Pharma] Ascentage Pharma announced that olverembatinib has been granted a Breakthrough Therapy Designation by the Center for Drug Evaluation of China’s National Medical Products Administration, for combination with low-intensity chemotherapy for the treatment of patients with Philadelphia chromosome-positive ALL.

Loss of Socs2 Improves Molecular Responses to IFNα in a Mouse Model of Myeloproliferative Neoplasms Driven by JAK2-V617F

March 11, 2025

[Leukemia] Researchers investigated the role of Socs2, a negative regulator of cytokine signaling, in modulating the response to pegIFNα in a JAK2-V617F mouse model of myeloproliferative neoplasms.

TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem and Progenitor Cells through Upregulation of Thrombopoietin Receptor Signaling

March 11, 2025

[Nature Communications] Through an epigenetic drug screen, scientists discovered that inhibition of disruptor of telomeric silencing 1-like, a H3K79 methyltransferase, selectively reduced the fitness of Tet2 knockout hematopoietic stem and progenitor cells.

Periarteriolar Niches Become Inflamed in Aging Bone Marrow, Remodeling the Stromal Microenvironment, and Depleting Lymphoid Progenitors

March 11, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Scientists performed single-cell RNA sequencing of mouse bone marrow stromal cells. They identified five transcriptionally distinct subsets of Leptin receptor–expressing cells, all of which expressed the highest levels of Stem Cell Factor and Cxcl12 in bone marrow throughout adult life.

Donor Telomeres and Their Magnitude of Shortening Post-Allogeneic Hematopoietic Cell Transplant Impact Survival for Patients with Early-Stage Leukemia or Myelodysplastic Syndrome

March 11, 2025

[eBioMedicine] Researchers evaluated the potential impact of donor leukocyte telomere length (LTL) and LTL shortening in recipients at three-month post-hematopoetic cell transplant (HCT) on the two-year HCT outcomes.

Increased RhoA Pathway Activation Downstream of αIIbβ3/SRC Contributes to Heterozygous Bernard Soulier Syndrome

March 11, 2025

[Haematologica] Scientists generated iPSCs from a Bernard Soulier Syndrome patient with a novel heterozygous GP1BA p.N103D mutation, resulting in moderate macrothrombocytopenia.

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

March 11, 2025

[American Journal of Hematology] The authors focus on approved and experimental treatments for myelofibrosis, highlighting their biological background.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.