Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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Deciphering the Effect of UM171 on Human Hematopoietic Progenitor Cell Fate Through Clonal Analysis

January 6, 2025

[Nature Communications] In addition to its HSC self-renewing property, scientists reported that UM171 specifically modulated cell fate of a precursor common to erythroid, megakaryocytic, and mast cells in favor of self-renewal and a mast-bias differentiation trajectory.

Global Trial Finding a Cure for Rare Childhood Cancer Opens

January 3, 2025

[University of Birmingham] A global trial has opened for children who have not responded to treatment for B-cell Non-Hodgkin Lymphoma, or who have relapsed.

FLI1 and GATA1 Govern TLN1 Transcription: New Insights into FLI1-Related Platelet Disorders

January 3, 2025

[Haematologica] Focusing on four FLI1 variants, two of which were novel, investigators assessed the impact of FLI1 variants on megakaryopoiesis using single-cell RNA sequencing. Defects were confirmed in patient platelets and cell lines.

Transplant and Nontransplant Salvage Therapy in Pediatric Relapsed or Refractory Hodgkin Lymphoma

January 3, 2025

[Jama Oncology] In this nonrandomized clinical trial, 59 patients with low-risk disease were identified, of which 41 received transplant-free salvage with a five-year progression-free survival (PFS) of 89.7%, and 18 received high-dose chemotherapy/autologous stem cell transplantoff protocol with a five-year PFS of 88.9%.

Reducing Functionally Defective Old HSCs Alleviates Aging-Related Phenotypes in Old Recipient Mice

January 2, 2025

[Cell Research] Through comprehensive molecular and functional analyses, scientists identified a subset of hematopoietic stem cells in aged mice that exhibited “younger” molecular profiles and functions, marked by low levels of CD150 expression.

Enhanced Engraftment of Human Hematopoietic Stem Cells via Mechanical Remodelling Mediated by the Corticotropin-Releasing Hormone

December 23, 2024

[Nature Biomedical Engineering] Scientists reported the role of the corticotropin-releasing hormone in enhancing the homing and engraftment of human-cord-blood hematopoietic stem and progenitor cells in bone marrow through mechanical remodelling.

A Phase 2 Pilot Study of Umbilical Cord Blood Infusion as an Adjuvant Consolidation Therapy in Elderly Patients with Acute Myeloid Leukemia

December 23, 2024

[Signal Transduction and Targeted Therapy] Investigators conducted a prospective, Phase II, single-arm trial of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly AML patients.

Dietary Methionine Supplementation Promotes Mice Hematopoiesis After Irradiation

December 23, 2024

[Military Medical Research] Scientists screened out the key amino acids that regulated hematopoietic reconstitution in the bone marrow by analyzing the changes in amino acids. They provided a theoretical basis for the treatment strategy of hematopoietic reconstruction after radiation.

Inflammasomes: Potential Therapeutic Targets in Hematopoietic Stem Cell Transplantation

December 19, 2024

[Cell Communication and Signaling] Researchers examine the molecular architecture and composition of various types of inflammasomes, highlighting their activation and effector mechanisms within the context of the HSCT process and its associated complications.

Evi1 Governs Kdm6b-Mediated Histone Demethylation to Regulate the Laptm4b-Driven mTOR Pathway in Hematopoietic Progenitor Cells

December 18, 2024

[Journal of Clinical Investigation] Upon induction of Ecotropic viral integration site 1 (Evi1) expression, mice displayed anemia, thrombocytopenia, lymphopenia, and erythroid and megakaryocyte dysplasia with a significant expansion of committed myeloid progenitor cells, resembling human myelodysplastic syndrome/myeloproliferative neoplasm–like disease.

Relationship Between Donor Source, Pre-Transplant Measurable Residual Disease, and Outcome After Allografting for Adults with Acute Myeloid Leukemia

December 16, 2024

[Leukemia] Investigators retrospectively analyzed 1265 myelodysplastic neoplasm/AML and AML patients allografted in first or second remission with an HLA-matched sibling or unrelated donor, HLA-mismatched unrelated donor, an HLA-haploidentical donor, or umbilical cord blood at a single institution.

PRMT1 Promotes the Self-Renewal of Leukemia Stem Cells by Regulating Protein Synthesis

December 16, 2024

[Advanced Science] The authors verified the critical role of protein arginine methyltransferase 1 (PRMT1) in the maintenance of chronic myeloid leukemia (CML) leukemia stem cells (LSCs). It was found that PRMT1 promoted the survival and serially plating abilities of human primary CML LSCs.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.