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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
YTHDC1 Is a Therapeutic Target for B Cell Acute Lymphoblastic Leukemia by Attenuating DNA Damage Response through the KMT2C-H3K4me1/me3 Epigenetic Axis
[Leukemia] Scientists showed that YTHDC1 was highly expressed in B cell acute lymphoblastic leukemia (B-ALL) cells. YTHDC1 knockdown attenuated B-ALL cell proliferation and cell cycle progression in vitro, and prolonged survival of mice in the human B-ALL xenograft model in vivo attributable to compromised leukemogenesis.
PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression
[Cancer Research] Investigators revealed that genetic and pharmacological suppression of PRDM16 greatly slowed the progression of FMS-like receptor tyrosine kinase-3-internal tandem duplication (FLT3-ITD)-driven leukemia, sensitized leukemic cells to tyrosine kinase inhibitors, and extended the survival of leukemic mice.
NAT10-Mediated mRNA N4-Acetylcytidine Reprograms Serine Metabolism to Drive Leukaemogenesis and Stemness in Acute Myeloid Leukemia
[Nature Cell Biology] The authors reported that mRNA N4-acetylcytidine and its catalytic enzyme NAT10 drive leukemogenesis and sustain self-renewal of leukemic stem cells/leukemia-initiating cells through reprogramming serine metabolism.
LMAN1 Serves as a Cargo Receptor for Thrombopoietin
[JCI Insight] Researchers showed that LMAN1 deficient mice exhibited mild thrombocytopenia, whereas the platelet count was normal in mice with approximately 7% Lman1 expression.
CXCR4 Signaling Determines the Fate of Hematopoietic Multipotent Progenitors by Stimulating mTOR Activity and Mitochondrial Metabolism
[Science Signaling] Scientists investigated the effects of increased CXCR4 signaling on the localization and fate of multipotent progenitors. Knock-in mice bearing a WHIM syndrome–associated CXCR4 mutation phenocopied the myeloid skewing of bone marrow in patients.
Mosaic Chromosomal Alterations (mCAs) in Individuals with Monoclonal B-Cell Lymphocytosis (MBL)
[Blood Cancer Journal] Both MBL and mCAs have been found to increase the risk of chronic lymphocytic leukemia and lymphoid malignancies, and researchers investigated how mCAs relate to MBL, which is currently unknown.
Outcomes with Intensive Treatment for Acute Myeloid Leukemia: An Analysis of Two Decades of Data from the HARMONY Alliance
[Haematologica] Investigators used a large pan-European multicenter dataset of the HARMONY Alliance to evaluate treatment-time dependent outcomes over two decades. In 5359 AML patients, they compared the impact of intensive induction therapy on outcome over four consecutive 5-year calendar periods from 1997 to 2016.
Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Neoplasms Arising Following Treatment for Multiple Myeloma: A Retrospective Study on Behalf of the Chronic Malignancies Working...
[Bone Marrow Transplantation] Our retrospective, EBMT registry study included 157 patients allografted between 2006 and 2018. Fifty-seven were transplanted for therapy-related myeloid leukemia and 100 for therapy-related myelodysplasia.
Emerging Insights into Epigenetics and Hematopoietic Stem Cell Trafficking in Age-Related Hematological Malignancies
[Current Stem Cell Research & Therapy] The authors provide an updated exploration of the functional aspects of bone marrow niche cells within the hematopoietic microenvironment in the context of age-related hematological malignancies.
Mariona Graupera and Anna Bigas Receive Two ERC Synergy Grants to Foster Innovative Knowledge on Haematological Disorders
[Josep Carreras Leukemia Research Institute] Dr. Anna Bigas, a member of the IMIM institute, will be in front of an ambitious project to develop a biological platform able to produce haematopoietic progenitor stem cells in the lab.
€9.8M ERC Synergy Grant Awarded to Study How Human Tissues Stay Healthy as We Age
[Francis Crick Institute] Researchers at the Francis Crick Institute and Queen Mary University of London have been awarded €9.8 million from the European Research Council to investigate how tissue homeostasis is maintained over time, and how genetic mutations can help or hinder this process.
Outcomes and Genetic Dynamics of Acute Myeloid Leukemia at First Relapse
[Haematologica] Investigators performed a comprehensive analysis of patients with relapsed AML to determine the genetic dynamics and factors predicting survival. They analyzed 875 patients with newly diagnosed AML who received intensive treatment or low-intensity treatment.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
