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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Selective Translational Control by PABPC1 Phase Separation Regulates Blast Crisis and Therapy Resistance in Chronic Myeloid Leukemia
[Nature Cell Biology] High-throughput CRISPR–Cas9 screening identified poly(A) binding protein cytoplasmic 1 (PABPC1) as a driver for chronic myeloid leukemia progression in the blast crisis stage.
The Proto-Oncogenic miR-106a-363 Cluster Enhances Adverse Risk Acute Myeloid Leukemia through Mitochondrial Activation
[Leukemia] Scientists investigated the clinical and functional role of the miR-106a-363 cluster in adult AML. Overexpression of the miR-106a-363 cluster and its individual members in a murine AML model significantly accelerated leukemogenesis.
Loss of Golga7 Suppresses Oncogenic Nras-Driven Leukemogenesis without Detectable Toxicity in Adult Mice
[Advanced Science] The authors used a Golga7 conditional knockout mouse line to assess the effects of Golga7 on the development and progression of NrasG12D-mutant chronic myelomonocytic leukemia-like myeloproliferative neoplasm.
A Gremlin 1-Expressing Splenic Niche Cell Population Restrains Chronic Myeloid Leukemia by Antagonizing the BMP Pathway
[Nature Cancer] Scientists reported that induced expression of the secreted protein Gremlin 1 in a mouse model restrained chronic myeloid leukemia (CML) progression and synergized with tyrosine kinase inhibitor treatment, whereas blockade of Gremlin 1 promoted CML development.
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
[Circulation] Investigators reported evidence that patients with cardiometabolic heart failure with preserved ejection fraction exhibited elevated peripheral blood hematopoietic stem cells.
SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells
[Cancer Research] Scientists validated the critical role of the histone methyltransferase SET and MYND domain containing 3 (SMYD3) in the maintenance of leukemia stem cells in chronic myeloid leukemia.
Impact of Hematopoietic Cell Transplantation and Quizartinib in Newly Diagnosed Patients with Acute Myeloid Leukemia and FMS-Like Tyrosine Kinase 3-Internal Tandem Duplications in the...
[Haematologica] QuANTUM-First was a randomized Phase III trial in newly diagnosed FLT3-ITDQpositive AML patients treated with quizartinib or placebo plus standard induction and consolidation chemotherapy and/or allogeneic hematopoietic cell transplantation, followed by single-agent maintenance therapy.
Bristol Myers Squibb Receives Approval from the European Commission to Expand Use of CAR T Cell Therapy Breyanzi for Relapsed or Refractory Follicular Lymphoma
[Bristol Myers Squibb] Bristol Myers Squibb announced that the European Commission has granted approval to Breyanzi®, a CD19-directed chimeric antigen receptor (CAR) T cell therapy, for the treatment of adult patients with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy.
Single-Cell Panleukemia Signatures of HSPC-Like Blasts Predict Drug Response and Clinical Outcome
[Blood] Through the integration of single-cell multiomics with bulk RNA-Seq and clinical datasets, scientists uncovered a chemotherapy-resistant subpopulation that resembled hematopoietic stem and progenitor cells and was associated with poor clinical outcomes across all subtypes investigated.
A TIM-3-Fc Decoy Secreted by Engineered T Cells Improves CD19 CAR-T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
[Blood] Researchers comprehensively characterized the expression of immune checkpoint receptors and their ligands in leukemic blasts, T cells, and mesenchymal stromal cells from B-cell acute lymphoblastic leukemia bone marrow (BM) samples at diagnosis and relapse, comparing them with age-matched healthy BM controls.
Pacylex Pharmaceuticals Announces the First Acute Myeloid Leukemia (AML) Patient Dosed with Zelenirstat in a New Phase I/II Clinical Trial
[Pacylex Pharmaceuticals, Inc.] Pacylex Pharmaceuticals, Inc. announced the launch of a new clinical trial of oral zelenirstat in refractory/relapsed AML patients and the dosing of the first patient.
Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review
[American Journal of Hematology] The authors provide a contemporary review on HSC transplantation for myelodysplastic neoplasms and myelofibrosis, highlighting up-to-date insights into disease biology, standard of care, and recommendations, as well as open avenues.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
