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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Cellino and Matricelf Announce Global Collaboration to Scale Personalized Spinal Cord Injury Treatments
[Cellino (BioSpace)] Cellino and Matricelf announced a collaboration to accelerate the global biomanufacturing of personalized spinal cord injury treatments using Cellino’s Nebula™ technology combined with Matricelf’s breakthrough regenerative approach.
Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates
[Advanced Science] Investigators reported that Wnt inhibitors safeguarded porcine ESCs from acquiring the extraembryonic endoderm (XEN) lineage. Porcine ESCs relied on Wnt inhibitors to maintain pluripotency. Without them, porcine ESCs exited from pluripotency and converted to XEN cells.
Advantages and Challenges of Ex Vivo Generation and Expansion of Human Hematopoietic Stem Cells from Pluripotent Stem Cells
[Experimental Hematology] The authors examine the current protocols for differentiating PSCs into hematopoietic stem cells and blood cells, highlighting their benefits and shortcomings.
Kyoto University Unveils New IPS Cell Manufacturing Facility
[The Pinnacle Gazette] Kyoto University iPS Cell Research Foundation, led by Director Dr. Shinya Yamanaka, opened the doors to its newest cell manufacturing facility. This initiative aims to produce iPSCs from patients' own cells.
A Chromatin-Focused CRISPR Screen Identifies USP22 As a Barrier to Somatic Cell Reprogramming
[Nature Communications] Using a focused CRISPR-Cas9 screen, scientists identified ubiquitin-specific peptidase 22 (USP22) as a key chromatin-based barrier to human iPSC derivation.
Generation of Hypoimmunogenic Universal iPS Cells through HLA-Type Gene Knockout
[Experimental & Molecular Medicine] Scientists generated hypoimmunogenic universal iPSCs through the targeted disruption of key genes, including human leukocyte antigen (HLA)-A, HLA-B, and HLA-DR alpha using the CRISPR–Cas9 system.
Pluripotency Superstar Oct4 Gets a Makeover
[The Scientist] The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.
Genetic Variation Modulates Susceptibility to Aberrant DNA Hypomethylation and Imprint Deregulation in Naive Pluripotent Stem Cells
[Stem Cell Reports] Investigators showed that naive PSCs from inbred mouse strains exhibited strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase inhibitor, a common approach to maintain naive pluripotency.
Ground-State Pluripotent Stem Cells Are Characterized by Rac1-Dependent Cadherin-Enriched F-Actin Complexes Icon for the Forest of Biologists
[Journal of Cell Science] Scientists investigated how the actin cytoskeleton was regulated in different pluripotency states. They observed a drastic reorganization during the transition from ground-state naïve mESCs into converted prime epiblast stem cells.
CHCHD2 Rescues the Mitochondrial Dysfunction in iPSC-Derived Neurons from Patient with Mohr-Tranebjaerg Syndrome
[Cell Death & Disease] To investigate the molecular mechanisms underlying Mohr-Tranebjaerg syndrome (MTS), scientists established iPSCs from a male MTS patient carrying a novel translocase of inner mitochondrial membrane 8 mutation.
iPSCs Engrafted in Allogeneic Hosts without Immunosuppression Induce Donor-Specific Tolerance to Secondary Allografts
[Proceedings of The National Academy of Sciences of The United States of America] Investigators found that iPSCs subcutaneously inoculated into MHC-compatible allogeneic host mice resisted rejection and formed teratomas without immunosuppressant administration.
Programming of Pluripotency and the Germ Line Co-Evolved from a Nanog Ancestor
[Cell Reports] Scientists discovered that Vent from the hemichordate Saccoglossus kowalevskii exhibited NANOG activity, programming pluripotency in Nanog−/− mouse pre-iPSCs and NANOG-depleted axolotl embryos.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
