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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Abu Dhabi Stem Cells Center Successfully Develops Virus-Free, Clinical-Grade Induced Pluripotent Stem Cells for First Time in the Middle East Using Exclusive Protocol
[ADSCC] The Abu Dhabi Stem Cells Center (ADSCC) have successfully developed clinical-grade iPSCs that complied with the Good Manufacturing Practice protocols and were, as such, compliant with the strictest international standards for clinical applications.
Bioreactor Allows Automated Long-Term Culturing of Stem Cells
[ISC] Researchers from the Fraunhofer Translational Center for Regenerative Therapies at the Fraunhofer Institute for Silicate Research (ISC) have developed a bioreactor that can be used for automated long-term culturing of human iPSCs.
Pluripotent Stem-Cell-Derived Therapies in Clinical Trial: A 2025 Update
[Cell Stem Cell] The authors review the landscape of interventional human PSC trials worldwide, highlighting available data on clinical safety and efficacy.
Cardiac Fibroblast BAG3 Regulates TGFBR2 Signaling and Fibrosis in Dilated Cardiomyopathy
[Journal of Clinical Investigation] Scientists used an isogenic pair of Bcl2-associated athanogene 3 (BAG3)-knockout and wild-type human iPSCs (hiPSCs) to interrogate the role of BAG3 in hiPSC-derived cardiac fibroblasts.
Protogenin Facilitates Trunk-to-Tail HOX Code Transition via Modulating GDF11/SMAD2 Signaling in Mammalian Embryos
[Communications Biology] Using human iPSC-derived presomitic mesoderm-like cells, scientists demonstrated delayed posterior HOX gene expression upon protogenin (PRTG) knockout, which was rescued by growth differentiation factor 11 (GDF11) supplementation.
Time-Efficient Strategies in Human iPS Cell-Derived Pancreatic Progenitor Differentiation and Cryopreservation: Advancing Towards Practical Applications
[Stem Cell Research & Therapy] Researchers differentiated the iPSCs derived from two pediatric Crohn’s disease patients into pancreatic progenitors and exocrine cells, adapting and shortening a protocol for differentiating ESCs.
DCP1A, a MEK Substrate, Regulates the Self-Renewal and Differentiation of Mouse Embryonic Stem Cells
[Cell Reports] To understand how mitogen-activated extracellular signal-regulated kinase (MEK) regulates pluripotency maintenance, through transcriptomics and proteomics analyses, researchers first demonstrated that MEK regulated gene expression at multiple post-transcriptional steps, including RNA splicing, nucleocytoplasmic transport, degradation, and translation.
Phospho-Regulation of ASCL1-Mediated Chromatin Opening During Cellular Reprogramming
[Development] Scientists investigated how levels of ASCL1 and its phosphorylation modulated its activity over progressive lineage restriction of mouse embryonic stem cells.
Understanding Human Oncogene Function and Cooperativity in Myeloid Malignancy Using iPSCs
[Experimental Hematology] It's safe to say that iPSC models are a mainstay of leukemia modeling “toolbox” alongside primary human cells from normal and patient sources. The authors discuss the rationale, history, challenges, and recent advances of iPSC models for modeling myeloid neoplasms.
Transposable Element Activity Captures Human Pluripotent Cell States
[EMBO Reports] Researchers engineered human PSCs with fluorescent reporters to capture the temporal expression dynamics of two state-specific transposable elements, LTR5_Hs, and MER51B. This dual reporter system enabled real-time monitoring and isolation of stem cells transitioning from naïve to primed pluripotency and further towards differentiation.
Epigenetic Reprogramming in Mouse and Human Primordial Germ Cells
[Experimental & Molecular Medicine] The authors provide a comprehensive overview of germline epigenetic reprogramming and its importance in mouse and human primordial germ cell (PGC) development. They also evaluate the extent to which in vitro culture techniques have replicated the development processes of human PGCs.
Induced Pluripotent Stem Cell–Related Approaches to Generate Dopaminergic Neurons for Parkinson’s Disease
[Neural Regeneration Research] The authors discuss the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
