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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Generation of iPSC-Derived Human Venous Endothelial Cells for the Modeling of Vascular Malformations and Drug Discovery
[Cell Stem Cell] Scientists devised a robust protocol for the generation of human induced VECs through manipulation of cell-cycle dynamics via the retinoic signaling pathway.
Human TSC2 Mutant Cells Exhibit Aberrations in Early Neurodevelopment Accompanied by Changes in the DNA Methylome
[Human Molecular Genetics] Scientists characterized the earliest stages of cortical development using human iPSCs in both monolayer and organoid culture models of tuberous sclerosis complex (TSC2)-deficiency in the brain.
KMT2C/KMT2D-Dependent H3K4me1 Mediates Changes in DNA Replication Timing and Origin Activity during a Cell Fate Transition
[Cell Reports] Using machine learning, investigators quantified 21 chromatin features predicting local DNA replication timing (RT) and RT changes during differentiation in ESCs.
Loss of 18q Alters TGFβ Signaling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
[Cell Proliferation] Researchers identified a diminished differentiation capacity to retinal progenitor cells in human ESCs with complex karyotypes that had in common the loss of part of chromosome 18q.
A Biallelically Active Embryonic Enhancer Dictates GNAS Imprinting through Allele-Specific Conformations
[Nature Communications] Researchers showed that the imprinting control region formed different chromatin conformations with each GNAS parental allele and enhanced two GNAS promoters in human embryonic stem cells.
Creative Medical Technology Holdings Expands Collaboration with Greenstone Biosciences to Accelerate iPSCelz Pipeline Development
[Creative Medical Technology Holdings, Inc. (BioSpace)] Creative Medical Technology Holdings, Inc. announced an expanded agreement with Greenstone Biosciences, Inc. to leverage atificial intelligence in further developing its human iPSC platform for diabetes treatment.
Streamlined Regulatory Documentation Accelerates Development of Next Generation Therapies
[Pluristyx] Pluristyx submitted a Type II Drug Master File (DMF) to the US FDA for its PluriBankâ„¢ CG (Clinical Grade) iPSC lines.
Atlas of Multilineage Stem Cell Differentiation Reveals TMEM88 as a Developmental Regulator of Blood Pressure
[Nature Communications] Scientists engineered barcoded iPSCs to generate an atlas of multilineage differentiation from pluripotency, encompassing an eight-day time course with modulation of WNT, BMP, and VEGF signaling pathways.
Gameto Announces FDA IND Clearance for Fertilo, the First iPSC-Based Therapy to Enter US Phase III Clinical Trials
[Gameto (Businesswire)] Gameto announced that the US FDA has cleared its Investigational New Drug (IND) application for Fertilo, to enable the launch of the first US-based Phase III clinical trial for an iPSC-based therapy.
A Serum- and Feeder-Free System to Generate CD4 and Regulatory T Cells from Human iPSCs
[Stem Cells] Scientists reported a serum- and feeder-free differentiation process suitable for large-scale production. Using an optimized concentration of PMA/Ionomycin, they generated iPSC-CD4sp T cells at high efficiency and converted them to Tregs using TGFβ and ATRA.
Engineered Heart Muscle Allografts for Heart Repair in Primates and Humans
[Nature] Scientists investigated the hypothesis that epicardial engineered heart muscle allografts from iPSC-derived cardiomyocytes and stromal cells structurally and functionally remuscularized the chronically failing heart without limiting side effects in rhesus macaques.
Highly Efficient Construction of Monkey Blastoid Capsules from Aged Somatic Cells
[Nature Communications] The authors demonstrated the efficient generation of blastoids from iPSCs and somatic cell nuclear transfer embryonic stem cells derived from aged monkeys, achieving an 80% formation efficiency.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
