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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Wdr5-Mediated H3K4 Methylation Facilitates HSPC Development via Maintenance of Genomic Stability in Zebrafish
[Proceedings of The National Academy of Sciences of The United States of America] Investigators demonstrated that tryptophan-aspartic acid (WD) repeat protein 5 (Wdr5)-mediated H3K4 methylation was crucial for maintaining genomic stability of proliferating hematopoietic stem and progenitor cells in zebrafish embryos.
Comprehensive Promotion of iPSC-CM Maturation by Integrating Metabolic Medium with Nanopatterning and Electrostimulation
[Nature Communications] Scientists demonstrated an approach that combined lipid-enriched maturation medium with a high concentration of calcium, nanopatterning of culture surfaces, and electrostimulation to generate hiPSC-derived cardiomyocytes with advanced electrophysiological, structural and metabolic phenotypes.
Genome-Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells
[Advanced Science] The authors conducted the first genome-wide identification of silencers in the mouse genome. In mouse embryonic fibroblasts and mESCs, 89 596 and 115 165 silencers were identified, respectively.
Cellino and Matricelf Announce Global Collaboration to Scale Personalized Spinal Cord Injury Treatments
[Cellino (BioSpace)] Cellino and Matricelf announced a collaboration to accelerate the global biomanufacturing of personalized spinal cord injury treatments using Cellino’s Nebula™ technology combined with Matricelf’s breakthrough regenerative approach.
Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates
[Advanced Science] Investigators reported that Wnt inhibitors safeguarded porcine ESCs from acquiring the extraembryonic endoderm (XEN) lineage. Porcine ESCs relied on Wnt inhibitors to maintain pluripotency. Without them, porcine ESCs exited from pluripotency and converted to XEN cells.
Advantages and Challenges of Ex Vivo Generation and Expansion of Human Hematopoietic Stem Cells from Pluripotent Stem Cells
[Experimental Hematology] The authors examine the current protocols for differentiating PSCs into hematopoietic stem cells and blood cells, highlighting their benefits and shortcomings.
Kyoto University Unveils New IPS Cell Manufacturing Facility
[The Pinnacle Gazette] Kyoto University iPS Cell Research Foundation, led by Director Dr. Shinya Yamanaka, opened the doors to its newest cell manufacturing facility. This initiative aims to produce iPSCs from patients' own cells.
A Chromatin-Focused CRISPR Screen Identifies USP22 As a Barrier to Somatic Cell Reprogramming
[Nature Communications] Using a focused CRISPR-Cas9 screen, scientists identified ubiquitin-specific peptidase 22 (USP22) as a key chromatin-based barrier to human iPSC derivation.
Generation of Hypoimmunogenic Universal iPS Cells through HLA-Type Gene Knockout
[Experimental & Molecular Medicine] Scientists generated hypoimmunogenic universal iPSCs through the targeted disruption of key genes, including human leukocyte antigen (HLA)-A, HLA-B, and HLA-DR alpha using the CRISPR–Cas9 system.
Pluripotency Superstar Oct4 Gets a Makeover
[The Scientist] The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.
Genetic Variation Modulates Susceptibility to Aberrant DNA Hypomethylation and Imprint Deregulation in Naive Pluripotent Stem Cells
[Stem Cell Reports] Investigators showed that naive PSCs from inbred mouse strains exhibited strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase inhibitor, a common approach to maintain naive pluripotency.
Ground-State Pluripotent Stem Cells Are Characterized by Rac1-Dependent Cadherin-Enriched F-Actin Complexes Icon for the Forest of Biologists
[Journal of Cell Science] Scientists investigated how the actin cytoskeleton was regulated in different pluripotency states. They observed a drastic reorganization during the transition from ground-state naïve mESCs into converted prime epiblast stem cells.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
