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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Nanosheet Promotes Chronic Wound Healing by Localizing Uncultured Stromal Vascular Fraction Cells
[Advances In Wound Care] Researchers developed an efficacious and efficient method for treating chronic wounds using “nanosheet” that improved the survival and localization of transplanted cells without prior seeding to optimally derive the regenerative potentials of uncultured stromal vascular fraction cells.
Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
[Circulation Research] To understand the importance of endothelial proliferation and migration for the beneficial versus adverse effects of vascular endothelial growth factor B (VEGF-B) in the heart, investigators explored the cardiac effects of autocrine versus paracrine VEGF-B expression in transgenic and gene-transduced mice.
A New Type of Blood–Brain Barrier Aminoacidopathy Underlies Metabolic Microcephaly Associated With SLC1A4 Mutations Get Access Arrow
[Brain] Scientists examined the phenotype and metabolic profile of three Slc1a4 mouse models, including a constitutive Slc1a4-KO mouse, a knock-in mouse with the major human Slc1a4 mutation, and a selective knockout of Slc1a4 in brain endothelial cells.
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
[Circulation] Investigators analyzed colony-forming, self-renewal, and vessel-forming potential of ATP binding cassette subfamily G member 2 (ABCG2)–expressing endothelial cells in human umbilical vessels. They developed Abcg2CreErt2;ROSA TdTomato mice and performed lineage tracing during mouse development and during tissue regeneration after myocardial infarction injury.
Efforts to Promote Osteogenesis-Angiogenesis Coupling for Bone Tissue Engineering
[Biomaterials Science] The authors summarize comprehensively and explored in depth current efforts to ameliorate the coupling of osteogenesis and angiogenesis from four aspects, namely the optimization of scaffold components, modification of scaffold structures, loading strategies for bioactive substances, and employment tricks for appropriate cells.
Compass Therapeutics Receives FDA Fast Track Designation for the Investigation of CTX-009 in Combination with Paclitaxel for the Treatment of Patients with Metastatic or...
[Compass Therapeutics, Inc.] Compass Therapeutics, announced that the US FDA has granted Fast Track Designation to CTX-009, the company’s bispecific DLL4/VEGF-A antibody, in combination with paclitaxel for the treatment of patients with metastatic or locally advanced BTC that have been previously treated.
Extracellular Vesicles Containing circMYBL1 Induce CD44 in Adenoid Cystic Carcinoma Cells and Pulmonary Endothelial Cells to Promote Lung Metastasis
[Cancer Research] Researchers identified a circRNA derived from MYBL1 pre-mRNA that accompanied overexpression of MYBL1 in adenoid cystic carcinoma (ACC). Overexpression of circMYBL1 was correlated with increased lung metastasis and poor overall survival in ACC patients.
VEGF-Induced Nrdp1 Deficiency in Vascular Endothelial Cells Promotes Cancer Metastasis by Degrading Vascular Basement Membrane
[Oncogene] Scientists showed that the conditional medium from hypoxia-incubated cancer cells induces extensive Nrdp1 downregulation in human and mouse vascular endothelial cells by VEGF, which activated CHIP, followed by Nrdp1 degradation in ubiquitin-proteasome-dependent way.
LAGE3 Promotes Angiogenesis on Hepatocellular Carcinoma by Stabilizing VEGFA mRNA
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Increased expression of LAGE3 cloud led to upregulated VEGFA secretion and angiogenesis in hepatocellular carcinoma. The mechanistic study revealed LAGE3 was required for the VEGFA mRNA stability.
Diosgenin Improves Post-myocardial Infarction Cardiac Function via HAND2-Induced Angiogenesis
[Biochemical And Biophysical Research Communications] Researchers revealed that diosgenin significantly improved cardiac function in a myocardial infarction mouse model, reducing cardiac fibrosis and cell apoptosis while promoting angiogenesis. Mechanistically, diosgenin upregulated the Hand2 expression, promoting the proliferation and migration of endothelial cells under hypoxic conditions.
Endothelial Cell Expression of a STING Gain-of-Function Mutation Initiates Pulmonary Lymphocytic Infiltration
[Cell Reports] To identify STING-expressing non-hematopoietic cell types required for the development of interstitial lung disease, investigators used a conditional knockin STINGV154M (VM) mutation model and direct expression of the VM allele to hematopoietic cells, fibroblasts, epithelial cells, or endothelial cells.
Vascular Endothelial Dysfunction Induced by 3-Bromofluoranthene via MAPK-Mediated-NFκB Pro-inflammatory Pathway and Intracellular ROS Generation
[Archives Of Toxicology] Disruption of vascular endothelial integrity and up-regulation of vascular endothelial permeability were induced by 3-BrFlu in a concentration-dependent manner through pro-inflammatory responses in vascular endothelial cells, namely, SVEC4-10 cells.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
