Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Dynamic Cytoskeletal Regulation of Cell Shape Supports Resilience of Lymphatic Endothelium

March 21, 2025

[Nature] Researchers identified dynamic cytoskeletal regulation of lymphatic endothelial cells shape, induced by isotropic stretch, as crucial for the integrity and function of dermal lymphatic capillaries.

Roles of TLR4 in Macrophage Immunity and Macrophage-Pulmonary Vascular/Lymphatic Endothelial Cell Interactions in Sepsis

March 21, 2025

[Communications Biology] Scientists uncovered that toll-like receptor 4 (TLR4) operated through multiple pathways in endothelial dysfunction: macrophage TLR4 mediated inflammatory damage to endothelial cells (ECs) and lymphatic ECs while endothelial TLR4 both directly sensitized cells to lipopolysaccharide-induced injury.

Embryonic Reprogramming of the Tumor Vasculature Reveals Targets for Cancer Therapy

March 18, 2025

[Proceedings of The National Academy of Sciences of The United States of America] An approach for identification of highly selective tumor endothelial markers was conducted to develop targeted antiangiogenic immunotherapies.

Single-Cell Atlas of Endothelial and Mural Cells across Primary and Metastatic Brain Tumors

March 18, 2025

[Immunity] Scientists analyzed the two major blood-brain barrier cell types, endothelial and mural cells, across non-tumor brain tissue, isocitrate dehydrogenase (IDH) mutant low-grade gliomas, IDH wild-type high-grade glioblastomas, and brain metastases from various primary tumors.

Endothelial TDP-43 Depletion Disrupts Core Blood-Brain Barrier Pathways in Neurodegeneration

March 17, 2025

[Nature Neuroscience] Researchers identified a disease-associated subset of capillary endothelial cells in Alzheimer’s disease, amyotrophic lateral sclerosis and frontotemporal degeneration. These capillaries exhibited reduced nuclear β-catenin and β-catenin-downstream genes, along with elevated TNF/NF-κB markers.

Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event

March 17, 2025

[Advanced Science] To determine how Borrelia burgdorferi (Bb) extravasate from circulation and whether Bb can cross the blood–brain barrier, researchers imaged Bb-microvessel interactions in non-tissue-specific and brain-specific tissue-engineered microvessel models perfused with GFP-labeled Bb.

Diagonal Therapeutics Initiates Natural History Study of Adults Living with Hereditary Hemorrhagic Telangiectasia (HHT), a Rare Bleeding Disorder with No Approved Treatments

March 17, 2025

[Diagonal Therapeutics] Diagonal Therapeutics announced the initiation of a natural history study for HTT in partnership with patient advocacy group Cure HHT. This non-interventional, observational, longitudinal evaluation aims to characterize the variability of patient-reported outcomes, including epistaxis, hematologic support, and quality of life.

The Pathways for Nanoparticle Transport across Tumor Endothelium

March 17, 2025

[Nature Nanotechnology] The authors discovered that tumor endothelial cell membrane ruffles captured circulating nanoparticles, internalized them in intracellular vesicles and released them into the tumour interstitium.

ARNT-Dependent HIF-2α Signaling Protects Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

March 17, 2025

[Communications Biology] Investigators revealed that endothelial Hif2α deletion led to increased cardiac microvascular permeability, disrupted barrier function, and elevated IL-6 expression in endothelial cells.

Mapping the Transcriptional and Epigenetic Landscape of Organotypic Endothelial Diversity in the Developing and Adult Mouse

March 17, 2025

[Nature Cardiovascular Research] Investigators profiled the accessible chromatin and transcriptional landscapes of the endothelium from the mouse liver, lung, heart, kidney, brain and retina, across developmental time, to identify potential transcriptional regulators of endothelial heterogeneity.

Keloid Vasculature Reacts to Intralesional Injection Therapies but Does Not Predict the Response to Treatment: Biopsies from Double-Blinded, Randomized, Controlled Trial

March 17, 2025

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Scientists utilized biopsies collected before, during and after the double-blinded randomized controlled trial comparing the intralesional treatments of 5-fluorouracil and triamcinolone injections in 48 human keloids.

The Role of VEGF in Cancer Angiogenesis and Tumorigenesis: Insights for Anti-VEGF Therapy

March 17, 2025

[Cytokine] The authors highlight recent advancements in the understanding of VEGF's molecular structure and its isoforms, as well as their implications in disease progression.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.