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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Tumor-Derived EBV-miR-BART2-5p Promotes Nasopharyngeal Carcinoma Metastasis by Inducing Pre-Metastatic Endothelial Cell Pyroptosis
[Molecular Cancer Research] The authors showed that the expression of pyroptosis-associated proteins was greater in the endothelial cells of metastatic nasopharyngeal carcinoma tissues than in those of nontumor tissues.
Endothelial Progenitor Cell-Derived Conditioned Medium Mitigates Chronic Cerebral Ischemic Injury Through Macrophage Migration Inhibitory Factor-Activated AKT Pathway
[Stem Cell Research & Therapy] Endothelial progenitor cell-derived conditioned medium was analyzed by cytokine array to identify key factors involved in angiogenesis and cellular senescence.
N-Acetylneuraminic Acid Triggers Endothelial Pyroptosis and Promotes Atherosclerosis Progression via GLS2-Mediated Glutaminolysis Pathway
[Cell Death Discovery] Researchers constructed GLS2−/−ApoE−/− mice by using HBLV-GLS2 shRNA injection. Immunofluorescence, western blotting, transmission electron microscopy were applied to detect profiles of endothelial injury and atherosclerosis progression.
Catalpol Regulates Apoptosis and Proliferation of Endothelial Cell via Activating HIF-1α/VEGF Signaling Pathway
[Scientific Reports] Scientists investigated whether Catalpol regulated apoptosis and proliferation following vascular injury induced by burns using an in vitro model of oxygen-glucose deprivation with a HUVEC line.
Extracellular Vesicles Derived from Endothelial Progenitor Cells Modified by Houshiheisan Promote Angiogenesis and Attenuate Cerebral Ischemic Injury via miR-126/PIK3R2
[Scientific Reports] Researchers investigated the impact of Houshiheisan-modified xtracellular vesicles-derived extracellular vesicles on angiogenesis using rats with permanent middle cerebral artery occlusion and brain microvascular endothelial cells subjected to oxygen-glucose deprivation.
SIRT3 Deficiency Promotes Lung Endothelial Pyroptosis through Impairing Mitophagy to Activate NLRP3 Inflammasome during Sepsis-Induced Acute Lung Injury
[Molecular and Cellular Biology] Scientists investigated the effects of sirtuin 3 deficiency on impaired mitophagy to promote lung endothelial cell pyroptosis during sepsis-induced acute lung injury.
Sandoz Receives European Commission Approval for Afqlir® (Aflibercept), Further Strengthening Leading Biosimilar Portfolio
[Sandoz] Sandoz announced that the European Commission has granted marketing authorization for Afqlir® 2 mg vial kit and pre-filled syringe for intravitreal injection. Afqlir® is indicated to treat various retinal diseases, including neovascular age-related macular degeneration.
Endothelial Heterogeneity in Bone Marrow: Insights Across Development, Adult Life, and Leukemia
[Leukemia] The authors highlight key milestones and recent advances in understanding vascular heterogeneity within bone marrow microenvironment during development, adulthood, and aging.
Specialized Post-Arterial Capillaries Facilitate Adult Bone Remodeling
[Nature Cell Biology] The authors identified a specialized type of post-arterial capillary, termed type R, involved in bone remodeling. Type R capillaries emerged during adolescence around trabecular bone, possessed a distinct morphology and molecular profile, and were associated with osteoprogenitors and bone-resorbing osteoclasts.
Activation of Lysosomal Ca2+ Channels Mitigates Mitochondrial Damage and Oxidative Stress
[Journal of Cell Biology] In human endothelial cells, researchers found that saturated fatty acids, including the plasma-predominant palmitic acid, caused mitochondrial fragmentation and elevation of intracellular reactive oxygen species levels.
Heart Foundation Vanguard Grant Awarded to Dr. Holly Voges
[Murdoch Children’s Research Institute] Murdoch Children’s Research Institute’s Dr. Holly Voges has received funding to better understand rheumatic heart disease (RHD), using cutting-edge stem cell technology.
CDK6-Mediated Endothelial Cell Cycle Acceleration Drives Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
[Nature Cardiovascular Research] Investigators reported a cyclin-dependent kinase 6 (CDK6)-driven mechanism of cell cycle deregulation involved in endothelial cell proliferation and hereditary hemorrhagic telangiectasia pathology.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
