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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Biocon Biologics Announces US FDA Approval for Jobevne™, Biosimilar Bevacizumab, Expanding Its Oncology Portfolio
[Biocon Biologics] Biocon Biologics announced that the US FDA has approved Jobevne™, a biosimilar Bevacizumab for intravenous use. JOBEVNE is a VEGF inhibitor that binds with VEGF and blocks the interaction with its receptors to prevent angiogenesis.
NexThera Completes First Patient Enrollment in US Clinical Trial for ‘NT-101,’ an Eye Drop Treatment for Wet AMD
[NexThera Co., Ltd. (BioSpace)] NexThera Co., Ltd. announced that it has completed the first patient enrollment for its Phase I/IIa clinical trial of NT-101, a novel eye drop treatment for wet AMD, at a clinical trial site in Pennsylvania.
ICAM-1/CD18-Mediated Sequestration of Parasitized Phagocytes in Cortical Capillaries Promotes Neuronal Colonization by Toxoplasma gondii
[Nature Communications] Scientists investigated the mechanisms of blood-brain barrier traversal by T. gondii and T. gondii-infected leukocytes, using intracarotid arterial delivery into the cerebral circulation of mice.
Single-Cell and Spatial Transcriptomics Reveals the Key Role of MCAM+ Tip-Like Endothelial Cells in Osteosarcoma Metastasis
[NPJ Precision Oncology] Researchers constructed a single-cell atlas of endothelial cells (ECs) using single-cell transcriptomic data. It was found that tip-like ECs were abundant in the primary tumors and metastatic foci.
FLT1-Enriched Extracellular Vesicles Induce a Positive Feedback Loop between Nasopharyngeal Carcinoma Cells and Endothelial Cells to Promote Angiogenesis and Tumor Metastasis
[Oncogene] Investigators revealed that FLT1-enriched extracellular vesicles induced a positive feedback loop between nasopharyngeal carcinoma cells and endothelial cells to promote tumor angiogenesis and tumor metastasis.
Lycopene Attenuates Trimethylamine-N-Oxide-Induced Senescence in Endothelial Progenitor Cells via the AMPK/SIRT1 Pathway
[Clinical and Experimental Hypertension] Researchers hypothesized that lycopene could mitigate trimethylamine-N-oxide-induced endothelial progenitor cells senescence, with involvement of the AMPK/SIRT1 pathway.
Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds
[ACS Nano ] Vascular endothelial growth factor plasmids-loaded macrophage exosomes were fabricated and enfolded in injectable self-healing hydrogels for programmed therapy of diabetic wounds through sequentially intrinsically modulating the inflammatory microenvironment and promoting angiogenesis.
Unravelling Soluble (Pro)Renin Receptor-Mediated Endothelial Dysfunction
[European Journal of Pharmacology] Human uterine microvascular endothelial cells were treated with 100 nM soluble prorenin receptor, with/without 10 nM PRO20, 10 μM losartan, or 10 μM aliskerin.
Engineering Advanced In Vitro Models of Endothelial Dysfunction
[Trends in Biotechnology] The authors examine developments and explore opportunities to develop next-generation in vitro models of endothelial dysfunction.
Ultrasound-Mediated Biomimetic Microbubbles Effectively Reverse LSECs Capillarization and Exert Antiplatelet Therapy in Liver Fibrosis
[Advanced Healthcare Materials] A type of multifunctional liposomal microbubbles carrying both Sim and platelet membrane had been designed for drug delivery targeting the inflammatory liver sinusoidal endothelial cells, with ultrasound-targeted microbubble destruction to mediate efficient release of these therapeutic agents inside the liver sinusoidal.
Cell Communication and Relevant Signaling Pathways in Osteogenesis-Angiogenesis Coupling
[Bone Research] The authors review the modes and processes of cell communication in osteogenesis-angiogenesis coupling over the past decade, mainly focusing on interactions among bone-related cells and vascular endothelial cells.
Htra4 Promotes Vascular Endothelial Cell Injury and Is Associated with the Early-Onset of Preeclampsia
[Scientific Reports] The authors investigated the alterations and potential role of high temperature requirement factor A4 (Htra4) in early-onset preeclampsia.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
