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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T
[Applied Biochemistry And Biotechnology] A bacterial EPS from the marine bacterium Halomonas malpeensis YU-PRIM-29T was used to treat the burn wound in vivo. In vitro biocompatibility of EPS-H29 was studied in human dermal fibroblasts and keratinocytes.
Dab2 (Disabled-2), an Adaptor Protein, Regulates Self-Renewal of Hair Follicle Stem Cells
[Communications Biology] Investigators reported that Dab2 conditional knockout mice exhibited a delay in the hair follicle cycle due to perturbed activation of hair follicle stem cells.
Alpha-9 Oncology Announces First Patient Dosed in Phase 1 Study of A9-3202 in Patients with Locally Advanced or Metastatic Melanoma
[Alpha-9 Oncology, Inc.] Alpha-9 Oncology, Inc. announced that the first participant has been dosed in the Phase I study evaluating 68Ga-A9-3202, a radiodiagnostic targeting melanocortin 1 receptor for the imaging of locally advanced or metastatic melanoma.
Melanoma Research Alliance Announces $12.6 Million Investment in Cutting Edge Melanoma Research
[Melanoma Research Alliance] The Melanoma Research Alliance announced its $12.6 million commitment to fund melanoma research supporting more than 30 scientists at leading academic and medical institutions in the United States and across the globe.
Sylvester Cancer Adding Cellular Therapy to its Arsenal against Metastatic Melanoma
[University of Miami Miller School of Medicine (EurekAlert!)] Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.
The Role of Yes Activated Protein (YAP) in Melanoma Metastasis
[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.
Exploration of the Photothermal Role of Curcumin-Loaded Targeted Carbon Nanotubes as a Potential Therapy for Melanoma Cancer
[Scientific Reports] Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte-Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Dermavant Announces FDA Acceptance of Supplemental New Drug Application (sNDA) for VTAMA® (Tapinarof) Cream, 1% for the Treatment of Atopic Dermatitis in Adults and...
[Dermavant Sciences, Inc.] Dermavant Sciences, Inc. announced that the US FDA accepted the company’s sNDA for VTAMA® cream, 1% for the topical treatment of atopic dermatitis in adults and children two years of age and older.
Skin Graft with Dermis and Appendages Generated In Vivo by Cell Competition
[Nature Communications] Scientists generated complete skin grafts with pluripotent stem cell-derived epidermis with appendages on p63 knockout embryos’ dermis.
Ribosomal S6 Kinase 2-Forkhead Box Protein O4 Signaling Pathway Plays an Essential Role in Melanogenesis
[Scientific Reports] Investigators reported that α-melanocyte-stimulating hormone, not ultraviolet (UV) UVA and UVB, acted as a major stimulus of melanogenesis in melanoma cells.
The Involvement of RIPK4 in TNF-α-Stimulated IL-6 and IL-8 Production by Melanoma Cells
[Journal Of Cancer Research And Clinical Oncology] The authors examined the effects of receptor-interacting protein kinase (RIPK4) downregulation on the transcriptomic profile of melanoma, and revealed a complex role for RIPK4 in regulating the immune signaling network in melanoma cells.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
