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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
U.S. FDA Approves ZEVASKYNâ„¢ (prademagene zamikeracel), the First and Only Cell-Based Gene Therapy for Patients with Recessive Dystrophic Epidermolysis Bullosa (RDEB)
[Abeona Therapeutics, Inc.] Abeona Therapeutics, Inc. announced the US FDA has approved ZEVASKYNâ„¢ gene-modified cellular sheets, also known as pz-cel, as the first and only autologous cell-based gene therapy for the treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa.
ZNF224 Enhances the Oncogenic Function of P21 via P53 and AKT Pathways in Melanoma
[FEBS Journal] Scientists investigated the molecular mechanisms underlying the oncogenic role of zinc finger protein 224 (ZNF224) in melanoma.
Molecular and Immune Landscape of Melanoma: A Risk Stratification Model for Precision Oncology
[Discover Oncology] Investigators provided a robust immune-related prognostic model for melanoma. They underscored the value of immune gene expression and T cell infiltration, particularly CD8+ T cells, in predicting patient outcomes.
Investigating the Properties of Truncal Acne: A Common but Often Overlooked Entity
[Journal of Cutaneous Medicine and Surgery] Researchers investigated the prevalence of truncal acne in patients with mild, moderate, and severe acne and evaluated the characteristics of truncal acne.
Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Promote the Growth of Human Hair Dermal Papilla Cells
[PLOS One] Investigators found that human umbilical cord mesenchymal stem cell-derived exosomes effectively enhanced the cell growth of human hair dermal papilla cells.
LncRNA SLNCR Phenocopies the E2F1 DNA Binding Site to Promote Melanoma Progression
[Cell Reports] Scientists showed that SLNCR binds to E2F1 to promote the proliferation, invasion, and migration of melanoma cells from the bloodstream into the lungs.
The Dynamic Interplay between Melanoma Cells and CAFs: Implications Drug Resistance and Immune Evasion and Possible Therapeutics
[Experimental Cell Research] The authors explore different subtypes of cancer-associated fibroblasts, their origins, and how they have evolved in their pro-tumorigenic roles in melanoma.
FesariusTherapeutics Announces Manufacturing Agreement for DermiSphere hDRT, the first hydrogel Dermal Regeneration Template
[FesariusTherapeutics, Inc. ] FesariusTherapeutics, Inc. announced it has entered into an exclusive, multi-year manufacturing and supply agreement with Regenity Biosciences. The agreement provides Regenity exclusive manufacturing responsibility for DermiSphere hDRT, an new class of collagen-based dermal regeneration templates.
Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors
[Cancer Research] Researchers investigated the role of nitrosylation, a nitric oxide-induced post-translational modification, in melanoma progression and therapeutic resistance.
Rechallenge of Ipilimumab and Nivolumab in Advanced Melanoma Patients after Previous Ipilimumab-Based Therapy
[British Journal of Cancer] Data from advanced melanoma patients rechallenged with ipilimumab+nivolumab after previous ipilimumab-containing treatment were retrieved from the nationwide Dutch Melanoma Treatment Registry.
Stromal Lipid Species Dictate Melanoma Metastasis and Tropism
[Cancer Cell] Researchers showed that abundant stromal lipids from young subcutaneous adipocytes, including phosphatidylcholines, are taken up by melanoma cells, where they upregulate melanoma PI3K-AKT signaling, fatty acid oxidation, oxidative phosphorylation leading to oxidative stress, resulting in decreased metastatic burden.
QPS Expands Offerings With Robust Pharmacology Disease Models, Including MASH, Ulcerative Colitis, Wound Healing, and Psoriasis
[QPS (BioSpace)] QPS is pleased to announce the expansion of its pharmacology disease models portfolio to include highly relevant models for metabolic dysfunction-associated steatohepatitis (MASH), ulcerative colitis, wound healing, and psoriasis.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
