Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Noninvasive Transdermal Delivery of STING Agonists Reshapes the Immune Microenvironment of Melanoma and Potentiates Checkpoint Blockade Therapy Efficacy
[ACS Applied Bio Materials] Scientists developed a disulfide-bearing transdermal nanovaccine by integrating a thiol-reactive agent lipoic acid into a metal-coordinated cyclic dinucleotide nanoassembly, designated as LA-Mn-cGAMP nanovaccines.
Is Colloidal Oat an Effective Emollient Ingredient for the Prevention and Treatment of Atopic Dermatitis in Infants?
[Journal of Dermatological Treatment] The authors evaluated clinical and preclinical studies on colloidal oat-containing emollients in pediatric atopic dermatitis (AD) treatment and prevention. Studies assessing skin barrier function, immune modulation, AD prevention, food allergy risk, and healthcare utilization were included.
Aulos Bioscience Doses First Patient in Phase II Cohort Evaluating AU-007 in Combination With Nivolumab for Second-Line Treatment of Melanoma
[AulosTM Bioscience] Aulosâ„¢ Bioscience announced dosing of its first patient with a combination of AU-007, the anti-PD-1 antibody nivolumab, and low-dose, subcutaneous aldesleukin in a Phase II expansion cohort focused on second-line treatment of melanoma.
A Dynamically Phase-Adaptive Regulating Hydrogel Promotes Ultrafast Anti-Fibrotic Wound Healing
[Nature Communications] A dynamically Schiff base-crosslinked hydrogel (F/R gel) with phase-adaptive regulating functions was constructed to integratedly promote rapid re-epithelialization with suppressed scars on chronic infected wounds.
Clinical Validation of Droplet Digital PCR Assays in Detecting BRAFV600-Mutant Circulating Tumor DNA As a Prognostic Biomarker in Patients with Resected Stage III Melanoma...
[The Lancet Oncology] Researchers investigated whether circulating tumour DNA measurements could predict survival outcomes during adjuvant targeted therapy or placebo treatment in stage III melanoma, thereby identifying patients at high risk and low risk of recurrence.
First-in-Human Clinical Trial of Vaccination with WDVAX, a Dendritic Cell Activating Scaffold Incorporating Autologous Tumor Cell Lysate, in Metastatic Melanoma Patients
[Cancer Immunology Research] In this Phase I trial in patients with metastatic melanoma, the cytokine GM-CSF and the innate TLR9 agonist CpG oligonucleotide were admixed with autologous tumor lysate onto a microporous poly-lactide-co-glycolide matrix polymer scaffold that achieved control over the spatial and temporal release of immunostimulatory agents in vivo.
Prolyl-tRNA Synthetase Inhibitor As a Novel First-in-Class Keloid Treatment: Downregulation of De Novo Collagen Synthesis and Inflammatory Cascade
[British Journal of Dermatology] Researchers investigated the anti-fibrotic activity of selective prolyl-tRNA synthetase inhibitors and elucidated the importance of DWN12088 as a first-in-class therapeutic agent for keloids.
Psychological Stress Increases Skin Infection through the Action of TGFβ to Suppress Immune-Acting Fibroblasts
[Science Immunology] Single-cell transcriptomics and lipidomic profiling in a mouse model of stress show that dermal fibroblasts undergoing adipogenesis have defective responses to Staphylococcus aureus skin infection.
Aulos Bioscience Doses First Patient in Phase II Cohort Evaluating AU-007 in Combination With Nivolumab for Second-Line Treatment of Melanoma
[Aulos Bioscience] Aulos Bioscience aannounced dosing of its first patient with a combination of AU-007, the anti-PD-1 antibody nivolumab and low-dose, subcutaneous aldesleukin in a Phase II expansion cohort focused on second-line treatment of melanoma.
Peripheral Positioning of Lysosomes Supports Melanoma Aggressiveness
[Nature Communications] Investigators analyzed lysosome subcellular distribution in patient-derived melanoma cells and patient biopsies and showed that lysosome spreading scales with melanoma aggressiveness.
Adjuvant BRAF/MEK Versus Anti-PD-1 in BRAF-Mutant Melanoma: A Propensity Score Matched Survival Analysis
[British Journal of Cancer] After PSM, no significant differences in outcomes were observed between adjuvant anti-PD-1 and BRAF/MEK-treated patients with stage III BRAF-mutant melanoma.
UVB-Induced Necroptosis of the Skin Cells via RIPK3-MLKL Activation Independent of RIPK1 Kinase Activity
[Cell Death Discovery] Scientists observed a reduction of receptor-interacting protein kinase 1 (RIPK1) protein after UVB exposure which led to activation of nuclear factor-kappa B n HaCaT cells.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
