Cord Blood News

[Circulation Research] Scientists used single-cell RNA sequencing and spatial transcriptomics to identify endothelial cell states after acute myocardial infarction in mice.

[Arteriosclerosis Thrombosis and Vascular Biology] The authors investigated ascending aortic aneurysm initiation by assessing the relation between aortic regurgitation and vascular activation and inflammation.

[Cancer Letters] Scientists established a single-cell atlas of endothelial cells (ECs) in gastric cancer and identified a subpopulation of COL1A1⁺ ECs that play a critical role in tumor progression and metastasis.

[Salk Institute] Salk Institute Professor Diana Hargreaves was named a 2025 All-Star Translational Award Program grantee by the V Foundation for Cancer Research.

[Oncoimmunology] The authors analyzed single-cell sequencing datasets and clinical specimens to evaluate the role of focal adhesion kinase (FAK) in the immune response of pancreatic cancer.

[Diabetes] Investigators developed a whole-slide scanned image analysis pipeline for semiautomated quantitation of endocrine area, islet frequency, interislet distance, and endocrine object size distribution.

[Cell Death Discovery] The authors comprehensively summarize the multifaceted roles of the Hippo signaling pathway in both physiological and pathological aspects of the pancreas, such as pancreas development, pancreatitis, PDAC, and diabetes.

[ACS Nano ] Researchers reported a strategy to combat the drug resistance of NSCLC to epidermal growth factor receptor tyrosine kinase inhibitors by constructing a cyclized bivalent aptamer-based proteolysis-targeting chimera which efficiently degraded c-Met and its interacting multiple tyrosine kinases.

[Advanced Science] Using RNA sequencing and quantitative reverse transcription PCR, TMEM99 is found upregulated in LUAD tissues and cell lines, correlating with poor patient outcomes.

[Cancer Letters] The authors unraveled a dual role of sphingosine kinase 1 (SPHK1) in KRAS-driven LUAD. While SPHK1 promotes tumorigenesis in in vitro experimental models, it paradoxically suppresses tumorigenesis in in vivo models of KRAS-mutated LUAD.

[Molecular Oncology] Researchers investigated the influence of Raf kinase inhibitory protein (RKIP) expression on NSCLC aggressiveness and explores its impact on therapy response, particularly to epidermal growth factor receptor (EGFR)-targeted therapies.

[Cancer Immunology Research] Scientists compared TIGIT-expressing and TIGIT deleted human CAR-NKs targeting the GD2 solid tumor antigen in tumor immune microenvironment (TiME) co-cultures and in vivo TiME xenografts designed to mimic the immunosuppressive environment of solid tumors.