Cord Blood News

[Circulation Research] Pulmonary hypertension (PH) animal models were generated by treating mice/rats with chronic hypoxia for four weeks. SMYD2-vTg mice or wild-type rats and mice treated with LLY-507 were used to investigate the function of suppressor of variegation, enhancer of zeste, trithorax and myeloid Nervy DEAF-1 domain-containing protein 2 (SMYD2) on PH development in vivo.

[eLife] Investigators identified heat shock cognate B as an indispensable protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+HSCs, as well as during megakaryopoiesis of the CD34+CD90+HSCs.

[Blood] This meta-analysis was based on the FDA guidance for considerations for a meta-analysis of minimal residual disease (MRD) as a clinical endpoint and evaluates MRD-negativity as an early endpoint reasonably likely to predict long-term clinical benefit.

[Blood Advances] Researchers characterized RUNX1 mutations outside of the runt homology domain. Their analysis of the patient data sets revealed that mutations within the C-terminus frequently occur in hematopoietic disorders.

[Blood] Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.

[Blood Advances] Scientists showed that CB-839 strongly reduced the mitochondrial respiration rate of bone marrow cells from JAK2-V617F mutant mice, demonstrating a marked dependence of these cells on glutamine-derived ATP production.

[Cell Stem Cell] Researchers reported that HSCs acquired metabolic resilience that promoted cell survival. High-resolution real-time ATP analysis with glucose tracing and metabolic flux analysis revealed that old HSCs reprogrammed their metabolism to activate the pentose phosphate pathway.

[Molecular Medicine] Investigators provide an extensive overview of the biological relevance of aberrant isoforms of genes involved in the regulation of apoptosis, activation of key cellular signaling pathways, and cell metabolism.

[Washington University School of Medicine in St. Loui] John F. DiPersio has received the Chancellor’s Award for Innovation and Entrepreneurship for his research contributions to the field of oncology that are paving the way for novel cancer therapies.

[FASEB Journal] In vitro culture assays demonstrated that MSCs suppressed the activation and function of CD4+ T cells by secreting interleukin 11, and neutralization of IL11 abrogated MSC-mediated suppression of CD4+ T cell function.

[Cellular and Molecular Life Sciences] The prognostic/predictive value of HMGA1 expression was assessed in a cohort of 301 STS patients at mRNA and protein level, by HTG EdgeSeq transcriptomics and immunohistochemistry, respectively.

[Advanced Science] A stepwise human induced pluripotent stem cells-to-MSCs differentiation method was employed via intermediate cell stages of neural crest and cytotrophoblast to generate lineage-specific MSCs with varying differentiation efficiencies and gene expression.