Cord Blood News

[Nature Communications] Researchers described a case of gene therapy-related T cell acute lymphoblastic leukemia that developed 4.7 years after treatment. The patient underwent chemotherapy and haploidentical transplantation and is currently in remission.

[Cell Reports] Scientists showed that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerged in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity.

[Luxa Biotechnology] Luxa Biotechnology has been awarded a $4 million grant from the California Institute for Regeneration Medicine, supporting its ongoing Phase I/IIa clinical study of the RPESC-RPE-4W cell transplantation for the treatment of dry age-related macular degeneration (AMD).

[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.

[EMBO Molecular Medicine] Scientists demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during radiotherapy through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1.

[Scientific Reports] Researchers analyzed the expression level of FSCN1 protein in liver cancer tissues and explored its diagnostic and application value in differentiating between HCC and intrahepatic cholangiocarcinom

[Hepatology] Scientists used a Western Diet Alcohol mouse model of alcohol-associated liver disease (ALD) to examine the hepatic myeloid cell compartment by scRNA seq and targeted Kupffer cell ablation to understand the diversity and function of liver macrophages in ALD.

[Journal Of Drug Targeting] The authors describe the process of fibrogenesis, and the phenotypic and functional characteristics of dendritic cells in the liver.

[American Journal of Physiology - Endocrinology and Metabolism] Human mesenteric vascular endothelial cells and human umbilical vein endothelial cells were treated with Testo with or without a NOX4 inhibitor or NOX4 siRNA.

[Disease Models & Mechanisms] Researchers investigated and characterized the effects of mechanical stimulation on the expression of angiogenic factors in retinal pigment epithelial cells both in vitro and in a mouse model.

[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.

[Immunity & Ageing] The authors discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.